MINI REVIEW article
Front. Pharmacol.
Sec. Neuropharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1697391
This article is part of the Research TopicMechanisms of Traumatic Brain Injury and its PharmacotherapyView all 7 articles
Post-Traumatic Epilepsy: Bridging Pathogenesis, Diagnosis, and Pharmacotherapeutic Strategies
Provisionally accepted
- 1West China Hospital, Sichuan University, Chengdu, China
- 2West China Fourth Hospital Sichuan University, Chengdu, China
- 3Xichang People's Hospital, Liangshan, China
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Post-traumatic epilepsy (PTE)—affecting 2-50% of traumatic brain injury (TBI) survivors with severity-dependent incidence—drives secondary neurodegeneration through elevated intracranial pressure (ICP), axonal injury, and neuroinflammatory cascades. While integrated risk stratification (e.g., cortical contusion, acute subdural hematoma on CT; blood-brain barrier disruption via dynamic contrast-enhanced MRI) enhances epileptogenesis prediction, mechanistic understanding of circuit reorganization underlying chronic hyperexcitability remains incomplete. Diagnosis integrates trauma history, seizure semiology, and multimodal monitoring (high-density EEG correlated with [18F] FDG-PET hypometabolism), yet evidence-based prophylaxis is confined to early PTE prevention. In this review, we will describe the progress in incidence, predictors, pathophysiological mechanisms diagnosis, prophylaxis, and treatments with the respect to PTE, providing a comprehensive overview of this subject.
Keywords: Traumatic Brain Injury, Epilepsy, seizure, predictors, prophylaxis, treatments
Received: 02 Sep 2025; Accepted: 23 Oct 2025.
Copyright: © 2025 Yang, Chen, Wang, Wu and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tong Sun, tongsun@stu.scu.edu.cn
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