MINI REVIEW article
Front. Pharmacol.
Sec. Drug Metabolism and Transport
Overcoming the Blood-Brain Barrier: Targeted Delivery Strategies for Gliomas
Provisionally accepted
- the 3RD Affiliated Hospital of Chengdu Medical College, Chengdu Pidu District People's Hospital, Chengdu, China
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Neurological gliomas, as the most common and deadly primary brain tumors, face two major therapeutic obstacles: the blockade of the blood-brain barrier (BBB) and high tumor heterogeneity. In recent years, research on novel drug delivery systems has brought hope for glioma treatment. This article elaborates on the research progress of novel drug delivery systems in glioma treatment, including various nanocarriers, targeted delivery strategies, and gene therapy drug delivery systems. It analyzes their advantages and challenges, outlooks future development directions, and aims to provide a reference for optimizing drug delivery systems for glioma therapy.
Keywords: Neurological Glioma, Drug Delivery Systems, Blood-Brain Barrier, Blood-tumor barrier, nanocarriers, targeted therapy
Received: 14 Sep 2025; Accepted: 11 Nov 2025.
Copyright: © 2025 Du, Chen, Zeng and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yijun Zeng, zhimlin28@163.com
Zhimei Lin, 43921932@qq.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.