BRIEF RESEARCH REPORT article
Front. Pharmacol.
Sec. Neuropharmacology
NEURO-FUNCTIONAL CORRELATES OF PERSONALITY DIMENSIONS IN PARKINSON'S DISEASE
Provisionally accepted
- 1INSERM U1214 Centre d'Imagerie Neuro Toulouse (ToNIC), Toulouse, France
- 2Centre Hospitalier Universitaire de Toulouse, Toulouse, France
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
ABSTRACT Introduction: According to the original model of the Temperament and Character Inventory (TCI), personality dimensions would be related to different neurotransmitters' systems such as the dopaminergic and the serotoninergic ones. Methods: Our objective was to study associations between functional connectivity and personality in Parkinson's disease (PD). The data of 29 PD patients were collected (NCT04705207). It included personality evaluation using the TCI, functional connectivity from resting-state functional MRI, and anxio-depressive state from the Hospital Anxiety and Depression scale (HAD). Seed-to-voxels and ROI-to-ROI analyses were done in the CONN toolbox. Results: Significant association was found between Novelty Seeking scores and functional connectivity within the nucleus accumbens and one cluster formed of the orbitofrontal cortex. Significant associations were also found between Harm Avoidance scores and functional connectivity within the temporal pole and seven clusters (mainly formed of the post-and pre-central gyri, thalami, parietal lobule, putamen and temporal gyrus). These functional connectivities also correlated with HAD scores. Conclusion: In accordance with the TCI model, Novelty Seeking seems to be related to the dopaminergic system within the nucleus accumbens and orbitofrontal cortex connectivity, implicated in impulsivity. Moreover, Harm Avoidance would be related to the serotoninergic system within the temporal and fronto-thalamo-parietal network connectivity, involved in depressive disorders.
Keywords: Personality, Temperament and Character Inventory, functional connectivity, RS-fMRI, Parkinson's disease
Received: 15 Sep 2025; Accepted: 28 Oct 2025.
Copyright: © 2025 Boussac, Harroch, Joineau, Descamps and Brefel-Courbon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mathilde Boussac, mathilde.boussac@inserm.fr
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.