REVIEW article
Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
This article is part of the Research TopicHarnessing the Medicinal Potential of Gut Microbiota for Human HealthView all 7 articles
Dietary polyphenols maintain human health through modulation of gut microbiota
Provisionally accepted
- 1Vignan's Foundation for Science, Technology and Research, Guntur, India
- 2Centro Federal de Educacao Tecnologica de Minas Gerais, Belo Horizonte, Brazil
- 3Birla Institute of Technology, Ranchi, India
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The symbiotic interplay between dietary polyphenols and gut microbiota constitutes a focal point in contemporary scientific investigations, with profound impact in human health and diseases. The human gastrointestinal milieu serves as the locus for a diverse consortium of microbial organisms, collectively constituting the gut microbiota, which intricately modulate host metabolism, immune responses, and overall homeostasis. Dysregulation of gut microbial composition and functionality, known as dysbiosis, has been implicated in the progression of a plethora of gastrointestinal and systemic maladies, encompassing inflammatory bowel diseases, metabolic syndromes and neurological disorders, and so on. Polyphenols abundant in plant-derived food, exert multifaceted biological activities, encompassing antioxidative, anti-inflammatory and anticancer properties, among many others. These polyphenolic metabolites inextricably interact with the gut microbiota, exerting modulatory effects on microbial composition and functionality, thereby promoting the symbiotic physiological relationships between microbe and human host. In reciprocal fashion, the gut microbiota serves as pivotal vectors in the metabolism and bioavailability of polyphenols, engendering bioactive signalling metabolites which regulate systemic physiological effects and thereby maintain host health. This review emphasizes the imperative of comprehensively delineating an interplay between polyphenolic metabolites and gut microbiota in maintaining host health, while reflecting potential interventions of protective health outcomes in disease conditions.
Keywords: Dietary polyphenols, Gut Microbiota, Polyphenol bioavailability, polyphenolmetabolites, Health Outcomes
Received: 21 Sep 2025; Accepted: 25 Nov 2025.
Copyright: © 2025 Rudrapal, Mauricio De Oliveira and Singh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mithun Rudrapal
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