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EDITORIAL article

Front. Pharmacol.

Sec. Pharmacology of Infectious Diseases

Volume 16 - 2025 | doi: 10.3389/fphar.2025.1712353

This article is part of the Research TopicMultidrug Resistant Bacteria: New Therapeutic Approaches for a Challenging ProblemView all 7 articles

Editorial: Multidrug-resistant bacteria: new therapeutic approaches for a MDR challenging problem

Provisionally accepted
Gabriela Cristina FernandezGabriela Cristina Fernandez1*Younes SmaniYounes Smani2,3Sonia Alejandra GomezSonia Alejandra Gomez4,5
  • 1Laboratorio de Fisiología de los Procesos Inflamatorios, Instituto de Medicina Experimental (IMEX)-CONICET/Academia Nacional de Medicina de Buenos Aires, CABA, Argentina
  • 2Andalusian Centro Andaluz de Biología del Desarrollo, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Pablo de Olavide., Seville, Spain
  • 3Departamento de Biología Molecular e Ingeniería Bioquímica, Universidad Pablo de Olavide., Seville, Spain
  • 4Servicio de Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas (INEI), ANLIS ‘Dr. Carlos G. Malbrán’,, CABA, Argentina
  • 5Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET),, CABA, Argentina

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Argentina. The misuse of antimicrobials has accelerated the emergence and spread of multidrug-resistant (MDR) bacterial strains, making infectious diseases increasingly difficult to treat and transforming this issue into a global crisis.Recently, it was estimated that in 2019, 1.3 million deaths were directly attributable to antimicrobial-resistant (AMR) bacterial pathogens (1). In this context, it is urgent to address critical areas, including the search for effective therapeutic alternatives, rapid diagnostics, and improved surveillance to detect emerging AMR pathogens. In this Research Topic, we have compiled six manuscripts that present novel findings and potential alternatives for the

Keywords: Antimicrobial resistance (AMR), alternative treatments, Nanotechnology, Pharmacokinetic modeling, genome-guided combination therapies,, Antibiotic combinations

Received: 24 Sep 2025; Accepted: 08 Oct 2025.

Copyright: © 2025 Fernandez, Smani and Gomez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Gabriela Cristina Fernandez, gfernandez@hematologia.anm.edu.ar

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material