REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Evaluation of Natural Products Bioactivity in Cardiovascular Diseases Utilizing Zebrafish Models: A Comprehensive Review
Provisionally accepted
Yiming Wang1Xiang Meng1Xuting Song1Lulu Wang1Xianghe Meng2Xiaoya Du3
Ziyoviddin Yusupov4Komiljon Tojibaev4Yunpeng Wang5*
Min He1*
Mengmeng Sun1*- 1Changchun University of Chinese Medicine, Changchun, China
- 2Wish Technology, Building E11, Area B, Beihu Science and Technology Park, Changchun, China
- 3Center for Food Evaluation, State Administration for Market Regulation, Beijing, China
- 4Institute of Botany, Academy of Sciences of Uzbekistan, Tashkent, Uzbekistan
- 5Jilin Academy of Agricultural Sciences, Changchun, China
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Cardiovascular diseases (CVDs) are a major global health challenge, significantly impacting public health and healthcare systems. Ethnopharmacological remedies and botanical medicines are widely used for the prevention and treatment of CVDs due to their multi-component, multi-target properties. Understanding the mechanisms of these natural products is essential for developing safe and effective therapies. The zebrafish model, an emerging tool in experimental pharmacology, has been increasingly used to evaluate the pharmacological activities of natural products. This review focuses the use of zebrafish models to test the prevention and treatment effects of various CVDs, and to investigate the inhibition of hyperlipidemia, thrombosis, the progress of heart failure, and the promotion of angiogenesis and toxicity. Emphasizing its experimental advantages-including the transparency characteristics of the body, its applicability to the analysis of multiple samples, and its support for real-time monitoring-aims to reveal its potential value in combining traditional cognition with contemporary pharmacological testing capabilities. The literature summary provides strong evidence for the cognitive improvement of the zebrafish system in clarifying the efficacy of natural ingredients in the cardiovascular field.
Keywords: Natural Products, Cardiovascular Diseases, Zebrafish, Bioactivity, Ethnopharmacology
Received: 26 Sep 2025; Accepted: 31 Oct 2025.
Copyright: © 2025 Wang, Meng, Song, Wang, Meng, Du, Yusupov, Tojibaev, Wang, He and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yunpeng Wang, wangypbio@163.com
Min He, hemin@ccucm.edu.cn
Mengmeng Sun, sunmm@ccucm.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.