- 1Università di Torino, Turin, Italy
- 2Università Campus Bio-Medico di Roma, Rome, Italy
- 3LAFMOL–Laboratory of Functional and Molecular Studies in Physiopharmacology, Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Piauí, Brazil
- 4CREA-Research Centre for Food and Nutrition, Rome, Italy
Editorial on the Research Topic
Emerging Trends in the Quality Check of Herbal Medicines, Supplements and ‘Botanicals’
1 Introduction
This Research Topic aims to explore and discuss emerging trends in the quality assessment of herbal medicines, supplements, and botanicals.
To gather further insights in the quality assessment of herbal products the following topics were addressed: comparative analysis of chemical and spectrophotometric techniques for quality assessment; identification and validation of quality markers in herbal products; development of sustainable and innovative analytical methods; challenges and solutions in standardizing quality checks for diverse herbal matrices; and management and utilization of data and databases in herbal medicine research. In this context, the present Research Topic, Emerging Trends in the Quality Check of Herbal Medicines, Supplements, and “Botanicals”, brings together 10 contributions that address these matters well from different points of view.
Some authors presented the development of new methodologies or applications and case studies of research. For instance, Wang et al. presented a quality evaluation of Polygonatum sibiricum slices from different regions based on appearance traits and multi-index metabolites combined with a technique for order preference by similarity to ideal solution—TOPSIS—and gray relation analysis. Zhou et al. aimed to authenticate Renshen Jianpi Wan (RSJPW), a classical CCPP composed of 11 prescribed botanical drugs, using DNA metabarcoding to overcome challenges in species-level identification of processed biological ingredients.
Xin et al. investigated metabolomic and lipidomic profiling of traditional Chinese medicine Testudinis Carapax et Plastrum and its substitutes.
Luis and Schneider reported a large variability in the alkaloid content of Corydalis yanhusuo dietary supplements available online in the United States.
Xu et al. studied the efficacy of Hongjing I granule, an herbal medicine, in patients with mild to moderate erectile dysfunction in a randomized controlled trial.
Bai and Dong presented the development and validation of the HPLC–MS/MS method and its application in the pharmacokinetic study of the Mongolian drug Sendeng-4 in rat blood plasma.
Lenssen and de Boer studied, through an analysis of EU and national case law from the Netherlands, including self-regulatory decision-making, the implications of case law on botanical health claims.
It is worth mentioning the article by Harnly et al. that carried out a review focused on one-class modeling for verification of botanical identity.
Hao et al. presented a review of botany, application, processing, phytochemistry, quality control, pharmacology, and toxicology of Euodiae Fructus.
Al-Sammarraie et al., by carrying out an artificial intelligence-aided scoping review of medicinal plant research in the Fertile Crescent, showed that the number of ethnobotanical studies was limited, suggesting an urgent need to prevent the loss of ancestral knowledge by formalizing it through evidence-based research and policy guidelines. Al-Sammarraie et al. suggested that to address these gaps through interdisciplinary collaboration and improved data-sharing, mechanisms will be crucial for advancing Traditional Arabic and Islamic Medicine research and medicinal plants.
Author contributions
NP: Conceptualization, Writing – original draft, Writing – review and editing. DDRA: Conceptualization, Writing – original draft, Writing – review and editing. ML: Conceptualization, Writing – original draft, Writing – review and editing. AD: Conceptualization, Writing – original draft, Writing – review and editing.
Funding
The author(s) declare that no financial support was received for the research and/or publication of this article.
Acknowledgments
We would like to acknowledge the authors and reviewers of the publications in this Research Topic for their invaluable contributions and efforts. We are also grateful to the editorial board members and support staff of the journal for their kind support during the preparation of this Research Topic.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Generative AI statement
The author(s) declare that no Generative AI was used in the creation of this manuscript.
Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible. If you identify any issues, please contact us.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Keywords: botanicals, quality assessment and control, emerging technologies, metrology, data management
Citation: Pilla N, Arcanjo DDR, Lucarini M and Durazzo A (2025) Editorial: Emerging trends in the quality check of herbal medicines, supplements, and “botanicals”. Front. Pharmacol. 16:1715714. doi: 10.3389/fphar.2025.1715714
Received: 29 September 2025; Accepted: 14 October 2025;
Published: 30 October 2025.
Edited and reviewed by:
Thomas Brendler, University of Johannesburg, South AfricaCopyright © 2025 Pilla, Arcanjo, Lucarini and Durazzo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Niccolò Pilla, bmljY29sby5waWxsYUB1bml0by5pdA==; Daniel Dias Rufino Arcanjo, ZGFuaWVsLmFyY2Fuam9AdWZwaS5lZHUuYnI=; Massimo Lucarini, bWFzc2ltby5sdWNhcmluaUBjcmVhLmdvdi5pdA==; Alessandra Durazzo, YWxlc3NhbmRyYS5kdXJhenpvQGNyZWEuZ292Lml0