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CORRECTION article

Front. Pharmacol.

Sec. Experimental Pharmacology and Drug Discovery

Correction: Evaluating the efficacy of HRZE-based regimens in a high-burden murine model: a back-translational assessment of rifamycins and moxifloxacin substitutions in tuberculosis treatment

Provisionally accepted
Jason  E CummingsJason E Cummings1Lisa  K WoolhiserLisa K Woolhiser1Vincent  GuglielmiVincent Guglielmi1Mackenzie  WernsmanMackenzie Wernsman1Ashley  RomanoAshley Romano1Samantha  PaulySamantha Pauly2John  T BelisleJohn T Belisle1Nicholas  D WalterNicholas D Walter2Gregory  T. RobertsonGregory T. Robertson1Richard  A SlaydenRichard A Slayden1*
  • 1Colorado State University, Fort Collins, United States
  • 2University of Colorado Anschutz Medical Campus, Aurora, United States

The final, formatted version of the article will be published soon.

A correction refers to a change to their article that the author wishes to publish after publication. The publication of this article is subject to Frontiers' editorial approval.Instructions:• Please read through all the templates before choosing • Pick the most relevant text template(s) from the following page and delete all others.• Edit the text as necessary, ensuring that the original incorrect text is included for the record, please see the below. • Please do not use any extra formatting when editing the templates, and only modify the red text unless absolutely necessary • Submit to Frontiers following the instructions on this page.When the original text contained incorrect information, to preserve the scientific record, please include that text when editing the below templates. For example:There was a mistake in the Funding statement, an incorrect number was used.The correct number is "2015C03Bd051.". The publisher apologizes for this mistake.The original version of this article has been updated. There was a mistake in Figure 1 as published. tuberculosis on Day -11 and one group was sacrificed at Day 1 post-infection to establish baseline lung bacterial burden. All remaining animals remained untreated until Day 0, at which point treatment (Tx) was initiated. Groups received treatment for 2, 4, or 8 weeks, with corresponding sacrifices on Days 12, 26, and 54 to assess treatment efficacy. Endpoints included colony-forming unit (CFU) enumeration and determination of RS Ratio. Day 54 mice were also evaluated for histopathological changes and PK analysis. A parallel untreated control group was maintained through the full 8-week period.

Keywords: High-burden Aerosol BALB/c model, High burden, Tuberculosis, mycobacteria, Drug Discovery

Received: 27 Oct 2025; Accepted: 28 Oct 2025.

Copyright: © 2025 Cummings, Woolhiser, Guglielmi, Wernsman, Romano, Pauly, Belisle, Walter, Robertson and Slayden. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Richard A Slayden, richard.slayden@colostate.edu

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