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CORRECTION article

Front. Pharmacol., 18 November 2025

Sec. Experimental Pharmacology and Drug Discovery

Volume 16 - 2025 | https://doi.org/10.3389/fphar.2025.1733648

Correction: Evaluating the efficacy of HRZE-based regimens in a high-burden murine model: a back-translational assessment of rifamycins and moxifloxacin substitutions in tuberculosis treatment

This article is a correction to:

  1. Evaluating the efficacy of HRZE-based regimens in a high-burden murine model: a back-translational assessment of rifamycins and moxifloxacin substitutions in tuberculosis treatment

    1. Read original article
Jason E. Cummings&#x;Jason E. Cummings1†Lisa K. Woolhiser&#x;Lisa K. Woolhiser1†Vincent GuglielmiVincent Guglielmi1Machenzie WernsmanMachenzie Wernsman1Ashley RomanoAshley Romano1Samantha Pauly,Samantha Pauly2,3John T. BelisleJohn T. Belisle1Nicholas D. Walter,,Nicholas D. Walter2,3,4Gregory T. Robertson,Gregory T. Robertson1,2Richard A. Slayden Richard A. Slayden1*
  • 1Mycobacteria Research Laboratories, Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States
  • 2Consortium for Applied Microbial Metrics, Aurora, CO, United States
  • 3Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States
  • 4Rocky Mountain Regional VA Medical Center, Aurora, CO, United States

A Correction on
Evaluating the efficacy of HRZE-based regimens in a high-burden murine model: a back-translational assessment of rifamycins and moxifloxacin substitutions in tuberculosis treatment

by Cummings JE, Woolhiser LK, Guglielmi V, Wernsman M, Romano A, Pauly S, Belisle JT, Walter ND, Robertson GT and Slayden RA (2025). Front. Pharmacol. 16:1667592. doi: 10.3389/fphar.2025.1667592

There was a mistake in Figure 1 as published. Figure S1 was published in place of the true Figure 1. The corrected Figure 1 appears below.

Figure 1
Study design for evaluating treatment duration-dependent responses to standard HRZE therapy in a murine model of Mycobacterium tuberculosis infection. Mice were aerosol-infected with M. tuberculosis on Day–11 and one group was sacri!ced at Day 1 post-infection to establish baseline lung bacterial burden. All remaining animals remained untreated until Day 0, at which point treatment (Tx) was initiated. Groups received treatment for 2, 4, or 8 weeks, with corresponding sacri!ces on Days 12, 26, and 54 to assess treatment ef!cacy. Endpoints included colony-forming unit (CFU) enumeration and determination of RS Ratio. Day 54 mice were also evaluated for histopathological changes and PK analysis.

Figure 1. Study design for evaluating treatment duration-dependent responses to standard HRZE therapy in a murine model of Mycobacterium tuberculosis infection. Mice were aerosol-infected with M. tuberculosis on Day−11 and one group was sacrificed at Day 1 post-infection to establish baseline lung bacterial burden. All remaining animals remained untreated until Day 0, at which point treatment (Tx) was initiated. Groups received treatment for 2, 4, or 8 weeks, with corresponding sacrifices on Days 12, 26, and 54 to assess treatment efficacy. Endpoints included colony-forming unit (CFU) enumeration and determination of RS Ratio. Day 54 mice were also evaluated for histopathological changes and PK analysis. A parallel untreated control group was maintained through the full 8-week period.

Supplemental material Figure S1 was omitted. The file has now been published.

The original article has been updated.

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Keywords: high-burden aerosol BALB/c model, high burden, tuberculosis, mycobacteria, drug discovery

Citation: Cummings JE, Woolhiser LK, Guglielmi V, Wernsman M, Romano A, Pauly S, Belisle JT, Walter ND, Robertson GT and Slayden RA (2025) Correction: Evaluating the efficacy of HRZE-based regimens in a high-burden murine model: a back-translational assessment of rifamycins and moxifloxacin substitutions in tuberculosis treatment. Front. Pharmacol. 16:1733648. doi: 10.3389/fphar.2025.1733648

Received: 27 October 2025; Accepted: 28 October 2025;
Published: 18 November 2025.

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Frontiers Editorial Office, Frontiers Media SA, Switzerland

Copyright © 2025 Cummings, Woolhiser, Guglielmi, Wernsman, Romano, Pauly, Belisle, Walter, Robertson and Slayden. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Richard A. Slayden, cmljaGFyZC5zbGF5ZGVuQGNvbG9zdGF0ZS5lZHU=

†These authors have contributed equally to this work

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.