EDITORIAL article
Front. Pharmacol.
Sec. Drug Metabolism and Transport
This article is part of the Research TopicNon-Invasive Methods in Drug Metabolism and Transport: Insights from Biological Samples to Oral AdministrationView all 6 articles
Editorial: Non-Invasive Methods in Drug Metabolism and Transport: Insights from Biological Samples to Oral Administration
Provisionally accepted
- 1University of Rzeszow, Rzeszów, Poland
- 2Qilu Pharmaceutical Co,. LTD, Shanghai, China
- 3Nemours Children's Health, Wilmington, United States
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The study of metabolism and transport of drugs, endogenous compounds, and environmental 15 chemicals plays a crucial role in understanding pharmacokinetics, optimising therapeutic outcomes, 16and reducing the risk of adverse effects. A more comprehensive understanding of drug metabolism and 17 transport within the body may be possible by combining non-invasive methods with oral administration 18 research. Non-invasive sampling methods include urinalysis, saliva analysis, hair analysis, and breath 19 testing. Qualification or quantitation of drugs, their metabolites, and other compounds in these samples 20 can be performed using various analytical techniques such as liquid chromatography (LC), gas 21 chromatography (GC), capillary electrophoresis (CE), and mass spectrometry (MS) (Alanazi et al., 22 2025;Hancu et al., 2021;Handland et al., 2016;Moura et al., 2023;Wróblewski et al., 2023). In 23 addition to non-invasive sampling techniques, oral medication administration offers both opportunities 24 and challenges for advancing our understanding of drug metabolism and transport. The oral drug 25 administration is the preferred route for drug delivery because it is convenient and widely accepted by 26 patients (Kim et al., 2023). However, various anatomical, biochemical, and physiological factors 27 affecting oral drug delivery must be taken into account (Lou et al., 2023). To ensure efficacy and safety, 28 thorough studies of bioavailability, absorption, distribution, and first-pass metabolism are necessary. 29This Research Topic includes five manuscripts that cover interdisciplinary studies on non-30 invasive methods in drug metabolism and transport. In the first study, Szultka-Młyńska et al. conducted 31 an electrochemical simulation of psychotropic drug metabolism and compared it to in-vivo processes 32 using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Electrochemistry (EC) and 33 liver microsome tests were utilised to produce transformation products (TPs) that arise from the 34 breakdown of psychiatric drugs to examine the possible TPs of target drugs. These TPs were then 35 further characterised using LC-MS/MS. By examining biological samples (human plasma) from 36 patients, the outcomes of EC-(LC)-MS and liver microsome assays were comparable with those of 37 traditional in-vivo investigations. Data from electrochemical oxidation, which predicted some of the 38 possible metabolites present in the human liver microsomes, concurred with data from in-vivo tests. 39The oxidative metabolism of some psychiatric medications can be accurately simulated using EC
Keywords: drug metabolism, transport of drugs, Biological Samples, oral administration, Drug Determination
Received: 30 Oct 2025; Accepted: 03 Nov 2025.
Copyright: © 2025 Wróblewski, ZHENG and Yue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Karol Wróblewski, karolw222@wp.pl
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