Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 20 Jul 2023

Physiologically-based pharmacokinetic modeling for single and multiple dosing regimens of ceftriaxone in healthy and chronic kidney disease populations: a tool for model-informed precision dosing

in Drug Metabolism and Transport

Fawaz Alasmari
Mohammed S. Alasmari
Hussa Mubarak Muwainea
Hatun A. Alomar
Abdullah F. Alasmari
Sary Alsanea
Aws Alshamsan
Muhammad F. Rasool
Faleh Alqahtani

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1200828

8,629 views
6 citations

Original Research

Published on 18 Jul 2023

CETP inhibitor evacetrapib enters mouse brain tissue

in Drug Metabolism and Transport

Jasmine Phénix
Jonathan Côté
Denis Dieme
Sherilyn J. Recinto
Felix Oestereich
Sasen Efrem
Sami Haddad
Michèle Bouchard
Lisa Marie Munter

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1171937

3,108 views
4 citations

Original Research

Published on 10 Jul 2023

Effects of bergapten on the pharmacokinetics of macitentan in rats both in vitro and in vivo

in Drug Metabolism and Transport

Jia Xu
Quan Zhou
Pengjiao Hou
Yu Wang
Peiwu Geng
Zebei Lu
Yunfang Zhou
Dapeng Dai
Shuanghu Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1204649

2,862 views
1 citation

Editorial

Published on 10 Jul 2023

Editorial: Drug metabolism and transport: the Frontier of personalized medicine

in Drug Metabolism and Transport

Junmin Zhang
Rong Wang
Sofia Azeredo Pereira

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1246827

2,209 views
2 citations

Original Research

Published on 07 Jul 2023

Absorption, tissue distribution, and excretion of glycycoumarin, a major bioactive coumarin from Chinese licorice (Glycyrrhiza uralensis Fisch)

in Drug Metabolism and Transport

Linhu Ye
Lei Cheng
Yan Deng
Sen Wang
Xinyu Wu
Shuiping Ou
Qi Chang
Xinqian Zhao
Wen Zhou
Jinghua Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1216985

3,135 views
3 citations

Clinical Trial

Published on 07 Jul 2023

Safety and efficacy of oil palm phenolic supplementation in improving lipid profile among hyperlipidemic adults: a phase 2, randomized, double-blind, placebo-controlled clinical trial

in Drug Metabolism and Transport

Nur Balqis Muhammad Ismail Tadj
Nurul `Izzah Ibrahim
Tg Mohd Ikhwan Tg Abu Bakar Sidik
Mohamed S. Zulfarina
Qodriyah Haji Mohd Saad
Soon-Sen Leow
Syed Fairus
Isa Naina Mohamed

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1190663

3,116 views
1 citation

Original Research

Published on 05 Jul 2023

Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and midazolam

in Drug Metabolism and Transport

Muluneh M. Fashe
Taryn A. Miner
John K. Fallon
Amanda P. Schauer
Craig Sykes
Philip C. Smith
Craig R. Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1218703

2,986 views
6 citations

Mini Review

Published on 28 Jun 2023

Human induced pluripotent stem cell–derived liver-on-a-chip for studying drug metabolism: the challenge of the cytochrome P450 family

in Drug Metabolism and Transport

Isabel Tamargo-Rubio
Anna Bella Simpson
Joanne A. Hoogerland
Jingyuan Fu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1223108

5,050 views
6 citations

Original Research

Published on 26 Jun 2023

Population pharmacokinetic analysis of transdermal granisetron in healthy Chinese and Caucasian volunteers

in Drug Metabolism and Transport

Jiayu Li
Pei Hu
Li Zhou
Fumiko Nagahama
Rui Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1154026

2,491 views

Original Research

Published on 20 Jun 2023

Rhubarb polysaccharide and berberine co-assembled nanoparticles ameliorate ulcerative colitis by regulating the intestinal flora

in Drug Metabolism and Transport

Yifan Feng
Chenyang Wu
Huan Chen
Tingting Zheng
Hanyi Ye
Jinrui Wang
Yinghua Zhang
Jia Gao
Ying Li
Zhengqi Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1184183

5,512 views
12 citations

Original Research

Published on 15 Jun 2023

Metabolism and toxicity of usnic acid and barbatic acid based on microsomes, S9 fraction, and 3T3 fibroblasts in vitro combined with a UPLC-Q-TOF-MS method

in Drug Metabolism and Transport

Hanxue Wang
Min Xuan
Juanjuan Diao
Nan Xu
Manlin Li
Cheng Huang
Changhong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1207928

3,222 views
5 citations

Original Research

Published on 14 Jun 2023

Morphine pharmacokinetics and opioid transporter expression at the blood-retina barrier of male and female mice

in Drug Metabolism and Transport

Casey-Tyler Berezin
Nikolas Bergum
Glenda M. Torres Lopez
Jozsef Vigh

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1206104

3,547 views
5 citations

Editorial

Published on 13 Jun 2023

Editorial: Clinical trials in drug metabolism and transport: 2022

in Drug Metabolism and Transport

Yurong Lai
Stanislav Yanev
Zhihao Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1223428

1,718 views

Original Research

Published on 31 May 2023

Development of a UPLC–MS/MS method for simultaneous therapeutic drug monitoring of anti-hepatocellular carcinoma drugs and analgesics in human plasma

in Drug Metabolism and Transport

Shijia Lu
Mingming Zhao
Limei Zhao
Guofei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1136735

3,761 views
3 citations

Original Research

Published on 22 May 2023

Effect of molecular distillation on the anti-inflammatory activity and neurotoxicity of Asarum essential oil

in Drug Metabolism and Transport

Yang Liu
Fang Wang
HuiWen Guo
Dingkun Zhang
Xiaofei Zhang
Zhenfeng Wu
Huiting Li
Yang Xian
Pengfei Yue
Ming Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1196137

2,956 views
7 citations

Editorial

Published on 18 May 2023

Editorial: Molecular imaging for tracking drug delivery

in Drug Metabolism and Transport

Zheng Han
Tom Driedonks
Wei Tang
Zijian Zhou
Lacey McNally

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1195229

1,742 views