Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 07 Oct 2022

SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™

in Drug Metabolism and Transport

Muhammad Talha Saleem
Muhammad Harris Shoaib
Rabia Ismail Yousuf
Farrukh Rafiq Ahmed
Kamran Ahmed
Fahad Siddiqui
Zafar Alam Mahmood
Muhammad Sikandar
Muhammad Suleman Imtiaz

Frontiers in Pharmacology

doi 10.3389/fphar.2022.974715

7,224 views
4 citations

Review

Published on 07 Oct 2022

Analyzing the metabolic fate of oral administration drugs: A review and state-of-the-art roadmap

in Drug Metabolism and Transport

Liu Liu
Yiming Liu
Xiaojie Zhou
Zhiwei Xu
Yehui Zhang
Liting Ji
Chunlan Hong
Changyu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2022.962718

6,643 views
3 citations

Original Research

Published on 05 Oct 2022

Predictive performance and verification of physiologically based pharmacokinetic model of propylthiouracil

in Drug Metabolism and Transport

Chaozhuang Shen
Dahu Liang
Xiaohu Wang
Wenxin Shao
Kuo Geng
Xingwen Wang
Hua Sun
Haitang Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1013432

3,547 views
13 citations

Correction

Published on 05 Oct 2022

Corrigendum: Evaluation of herb–drug interaction between Danshen and rivaroxaban in rat and human liver microsomes

in Drug Metabolism and Transport

Xu Wang
Jingjing Fa
Yuanjin Zhang
Shengbo Huang
Jie Liu
Junqing Gao
Lina Xing
Zongjun Liu
Xin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1039267

1,251 views

Original Research

Published on 05 Oct 2022

Pharmacokinetics and safety of the two oral cefaclor formulations in healthy chinese subjects in the fasting and postprandial states

in Drug Metabolism and Transport

Xinyao Qu
Qiaohuan Deng
Ying Li
Peng Li
Guangwen Liu
Yanli Wang
Zhengzhi Liu
Shuang Yu
Yang Cheng
Yannan Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1012294

3,636 views
4 citations

Original Research

Published on 04 Oct 2022

Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate

in Drug Metabolism and Transport

Jiahong Xiang
Mengqi Wu
Jianchao Wang
Mengmeng Lin
Mengmeng Sun
Xin Li
Ruijuan Xing
Ran Guo
Jianmin Gu
Tao Lyu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1001308

4,028 views
3 citations

Original Research

Published on 04 Oct 2022

Formulation of ciprofloxacin-loaded oral self-emulsifying drug delivery system to improve the pharmacokinetics and antibacterial activity

in Drug Metabolism and Transport

Asghar Ali Asghar
Muhammad Akhlaq
Aamir Jalil
Abul Kalam Azad
Junaid Asghar
Muhammad Adeel
Ghadeer M. Albadrani
Amin A. Al-Doaiss
Mohamed Kamel
Ahmed E. Altyar

Frontiers in Pharmacology

doi 10.3389/fphar.2022.967106

5,692 views
9 citations

Original Research

Published on 30 Sep 2022

Pharmacokinetic study of single and multiple oral administration of glutamine in healthy Beagles

in Drug Metabolism and Transport

Fanxi Guo
Dongying Liu
Yuqing Zhou
Yuanqian Yu
Yidan Xu
Yuanpeng Zou
Chongyang Li
Fengyichi Zhang
Zugong Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1014474

3,199 views

Original Research

Published on 30 Sep 2022

External evaluation of published population pharmacokinetic models of posaconazole

in Drug Metabolism and Transport

Shuqi Huang
Qin Ding
Nan Yang
Zexu Sun
Qian Cheng
Wei Liu
Yejun Li
Xin Chen
Cuifang Wu
Qi Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1005348

2,787 views
5 citations

Review

Published on 29 Sep 2022

Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation?

in Drug Metabolism and Transport

Ramyia Elangovan
Julien Baruteau

Frontiers in Pharmacology

doi 10.3389/fphar.2022.972468

26,906 views
15 citations

Original Research

Published on 29 Sep 2022

Study and exploration of the pharmacokinetics of traditional Tibetan medicine Ruyi Zhenbao tablets after single and long-term administration

in Drug Metabolism and Transport

Hongping Hou
Tengfei Chen
Ziying Xu
Zihui Yu
Caixia Wang
Rongxia Liu
Bo Peng
Wei Yang
Feng Li
Xiangyi Che

Frontiers in Pharmacology

doi 10.3389/fphar.2022.948693

3,590 views

Original Research

Published on 26 Sep 2022

Population pharmacokinetic model of vancomycin in postoperative neurosurgical patients

in Drug Metabolism and Transport

Shifeng Wei
Dongjie Zhang
Zhigang Zhao
Shenghui Mei

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1005791

3,498 views
5 citations

Original Research

Published on 23 Sep 2022

Simulation of the crosstalk between glucose and acetaminophen metabolism in a liver zonation model

in Drug Metabolism and Transport

Kazuhiro Maeda
Shuta Hagimori
Masahiro Sugimoto
Yasuyuki Sakai
Masaki Nishikawa

Frontiers in Pharmacology

doi 10.3389/fphar.2022.995597

3,264 views

Original Research

Published on 23 Sep 2022

Prediction of pyrotinib exposure based on physiologically-based pharmacokinetic model and endogenous biomarker

in Drug Metabolism and Transport

Miao Zhang
Zhiheng Yu
Xueting Yao
Zihan Lei
Kaijing Zhao
Wenqian Wang
Xue Zhang
Xijing Chen
Dongyang Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.972411

2,811 views
6 citations

Original Research

Published on 21 Sep 2022

Impact of pregnancy related hormones on drug metabolizing enzyme and transport protein concentrations in human hepatocytes

in Drug Metabolism and Transport

Muluneh M. Fashe
John K. Fallon
Taryn A. Miner
Jacqueline B. Tiley
Philip C. Smith
Craig R. Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1004010

4,727 views
12 citations

Original Research

Published on 19 Sep 2022

Metabolomics study of treatment response to conbercept of patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

in Drug Metabolism and Transport

Yinchen Shen
Hanying Wang
Xiaoyin Xu
Chong Chen
Shaopin Zhu
Lu Cheng
Junwei Fang
Kun Liu
Xun Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.991879

2,998 views
7 citations