Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 01 Oct 2021

Resveratrol on the Metabolic Reprogramming in Liver: Implications for Advanced Atherosclerosis

in Drug Metabolism and Transport

Ying Ma
Dongliang Li
Wenfeng Liu
Xiaoxiao Liu
Yingqi Xu
Xinrui Zhong
Fengnan Zhi
Xueling Jia
Yanan Jiang
Yuhua Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2021.747625

5,351 views
11 citations

Original Research

Published on 27 Sep 2021

Evaluation of a Clinically Relevant Drug–Drug Interaction Between Rosuvastatin and Clopidogrel and the Risk of Hepatotoxicity

in Drug Metabolism and Transport

Chen Ning
Shengdi Su
Jiaming Li
Dexuan Kong
Hui Cai
Zhiying Qin
Han Xing
Xijing Chen
Jiake He

Frontiers in Pharmacology

doi 10.3389/fphar.2021.715577

8,873 views
7 citations

Original Research

Published on 17 Sep 2021

Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach

in Drug Metabolism and Transport

Punyabhorn Rattanacheeworn
Stephen J Kerr
Wonngarm Kittanamongkolchai
Natavudh Townamchai
Suwasin Udomkarnjananun
Kearkiat Praditpornsilpa
Thanundorn Thanusuwannasak
Udomsak Udomnilobol
Suree Jianmongkol
Boonsri Ongpipattanakul

Frontiers in Pharmacology

doi 10.3389/fphar.2021.726669

5,614 views
20 citations

Clinical Trial

Published on 17 Sep 2021

Safety, Tolerability, and Pharmacokinetics of a Novel Mitochondrial Modulator, TRC150094, in Overweight and Obese Subjects: A Randomized Phase-I Clinical Trial

in Drug Metabolism and Transport

Deepa Joshi
Prashant Jamadarkhana
Suchit Kumbhare
Amarinder Singh
Jignesh Kotecha
Deepak Bunger
Ajay Shiwalkar
Anookh Mohanan
Chaitanya Dutt

Frontiers in Pharmacology

doi 10.3389/fphar.2021.729424

3,804 views
5 citations

Original Research

Published on 14 Sep 2021

Sex Metabolic Differences and Effects on Blood Coagulation Among Rats Exposed to Sodium Dehydroacetate

in Drug Metabolism and Transport

Xin Chen
Fuxing Hao
Meng Zhang
Jinzha Xiao
Weiya Zhao
Zeting Zhao
Yumei Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.727084

2,697 views
8 citations

Original Research

Published on 26 Aug 2021

Influence of FMO3 and CYP3A4 Polymorphisms on the Pharmacokinetics of Teneligliptin in Humans

in Drug Metabolism and Transport

Jin-Woo Park
Kyoung-Ah Kim
Jong-Min Kim
In-Hwan Park
Ji-Young Park

Frontiers in Pharmacology

doi 10.3389/fphar.2021.736317

2,954 views
2 citations

Original Research

Published on 25 Aug 2021

Population Pharmacokinetics of Polymyxin B and Dosage Optimization in Renal Transplant Patients

in Drug Metabolism and Transport

Ying Li
Yang Deng
Zhen-Yu Zhu
Yi-Ping Liu
Ping Xu
Xin Li
Yue-Liang Xie
Heng-Chang Yao
Liu Yang
Bi-Kui Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.727170

5,289 views
36 citations

Original Research

Published on 24 Aug 2021

Optimized Dosing Regimens of Meropenem in Septic Children Receiving Extracorporeal Life Support

in Drug Metabolism and Transport

Yixue Wang
Weiming Chen
Yidie Huang
Guangfei Wang
Zhiping Li
Gangfeng Yan
Chao Chen
Guoping Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.699191

8,926 views
8 citations

Original Research

Published on 24 Aug 2021

Cell-Penetrating Peptides Predicted From CASC3, AKIP1, and AHRR Proteins

in Drug Metabolism and Transport

Ly Porosk
Kaisa Põhako
Piret Arukuusk
Ülo Langel

Frontiers in Pharmacology

doi 10.3389/fphar.2021.716226

3,555 views
2 citations

Original Research

Published on 23 Aug 2021

A Comprehensive Analysis of Metabolomics and Transcriptomics Reveals Novel Biomarkers and Mechanistic Insights on Lorlatinib Crosses the Blood-Brain Barrier

in Drug Metabolism and Transport

Wei Chen
Chunyu Li
Yafei Shi
Yujun Zhang
Dujia Jin
Mingyu Zhang
Mingming Bo
Guohui Li

Frontiers in Pharmacology

doi 10.3389/fphar.2021.722627

3,765 views
5 citations

Original Research

Published on 13 Aug 2021

Distribution Evaluation of Tenofovir in the Breast Milk of Mothers With HBeAg-Positive Chronic HBV Infection After Treatment With Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate by a Sensitive UPLC-MS/MS Method

in Drug Metabolism and Transport

Na Yang
Guanlun Zhou
Xiaoliang Cheng
Jun He
Yan Chen
Chao Chen
Meijuan Li
Jiajia Ge
Min Wang
Tianqi Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.734760

4,989 views
9 citations

Original Research

Published on 13 Aug 2021

(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells

in Drug Metabolism and Transport

Alzbeta Stefela
Miroslav Kaspar
Martin Drastik
Thales Kronenberger
Stanislav Micuda
Martin Dracinsky
Blanka Klepetarova
Eva Kudova
Petr Pavek

Frontiers in Pharmacology

doi 10.3389/fphar.2021.713149

7,866 views
10 citations

Review

Published on 10 Aug 2021

An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters

in Drug Metabolism and Transport

Vojtech Dvorak
Tabea Wiedmer
Alvaro Ingles-Prieto
Patrick Altermatt
Helena Batoulis
Felix Bärenz
Eckhard Bender
Daniela Digles
Franz Dürrenberger
Laura H. Heitman

Frontiers in Pharmacology

doi 10.3389/fphar.2021.722889

30,561 views
57 citations

Original Research

Published on 04 Aug 2021

Regulation of ABC Drug Efflux Transporters in Human T-Cells Exposed to an HIV Pseudotype

in Drug Metabolism and Transport

Sana-Kay Whyte-Allman
Rupert Kaul
Reina Bendayan

Frontiers in Pharmacology

doi 10.3389/fphar.2021.711999

3,153 views
6 citations

Original Research

Published on 23 Jul 2021

Prediction of Rivaroxaban-Rifampin Interaction After Major Orthopedic Surgery: Physiologically Based Pharmacokinetic Modeling and Simulation

in Drug Metabolism and Transport

Rui-juan Xu
Tao Ling
Hong Tang
Wei-hong Ge
Qing Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.706781

8,423 views
4 citations

Original Research

Published on 15 Jul 2021

A Metabolic Pattern in Healthy Subjects Given a Single Dose of Metformin: A Metabolomics Approach

in Drug Metabolism and Transport

Lina A. Dahabiyeh
Muhammad Mujammami
Tawfiq Arafat
Hicham Benabdelkamel
Assim A. Alfadda
Anas M. Abdel Rahman

Frontiers in Pharmacology

doi 10.3389/fphar.2021.705932

6,406 views
29 citations