Frontiers in Pharmacology | Drug Metabolism and Transport

Methods

Published on 26 Jun 2024

Pharmacokinetic profile of phenytoin in dried blood spot with high-performance liquid chromatography—photodiode array

in Drug Metabolism and Transport

Yahdiana Harahap
Limeylia Ng
Sunarsih Sunarsih

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1326996

2,405 views

Original Research

Published on 21 Jun 2024

Exploring the pharmacokinetics and tolerability of cyclooxygenase inhibitor ampiroxicam: a phase I study on single and multiple oral doses

in Drug Metabolism and Transport

Pengfei Zhao
Ying Qi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1429971

2,055 views

Original Research

Published on 20 Jun 2024

Systematic studies on the kinetic process of 20(S)-protopanaxadiol in rats and dogs: absorption, distribution, metabolism and excretion

in Drug Metabolism and Transport

Pengfei Li
Min Zhang
Meng Chen
Guangxu Liu
Linghui Meng
Dan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1430780

1,815 views
3 citations

Original Research

Published on 19 Jun 2024

Development of radioiodine-labeled mequitazine for evaluation of hepatic CYP2D activity

in Drug Metabolism and Transport

Asuka Mizutani
Masato Kobayashi
Kodai Nishi
Ken-ichi Fujita
Kotaro Takahashi
Yuka Muranaka
Kakeru Sato
Masanori Kitamura
Chie Suzuki
Ryuichi Nishii

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1397288

1,445 views

Original Research

Published on 14 Jun 2024

Preclinical pharmacokinetic characterization of amdizalisib, a novel PI3Kδ inhibitor for the treatment of hematological malignancies

in Drug Metabolism and Transport

Shuwen Jiang
Xiangkun Li
Weifang Xue
Sumei Xia
Jian Wang
Yang Sai
Guangxiu Dai
Weiguo Su

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1392209

1,980 views
5 citations

Original Research

Published on 12 Jun 2024

A phase I, randomized study to evaluate the safety, tolerability, and pharmacokinetics of mefunidone in healthy subjects

in Drug Metabolism and Transport

Mai Han
Bishan Huo
Gaoyun Hu
Xin Zhang
Gang Cui
Wei Wu
Na Mi
Shixi Zhang
Jiangli Jin
Xing Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1414066

1,939 views
2 citations

Original Research

Published on 11 Jun 2024

Development and validation of UPLC-MS/MS method for icariin and its metabolites in mouse urine

in Drug Metabolism and Transport

Na Li
Mei Yuan
Jinjing Che

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1389754

1,795 views
1 citation

Original Research

Published on 24 May 2024

Amino acid metabolomics and machine learning for assessment of post-hepatectomy liver regeneration

in Drug Metabolism and Transport

Yuqing Yan
Qianping Chen
Xiaoming Dai
Zhiqiang Xiang
Zhangtao Long
Yachen Wu
Hui Jiang
Jianjun Zou
Mu Wang
Zhu Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1345099

2,628 views

Original Research

Published on 24 May 2024

The influence of drug-induced metabolic enzyme activity inhibition and CYP3A4 gene polymorphism on aumolertinib metabolism

in Drug Metabolism and Transport

Feng Ye
Jinhuan Ni
Xinyue Li
Jing Wang
Jianchao Luo
Shiyu Wang
Xiaoyu Xu
Yunshan Zhong
Jianchang Qian
Zhongxiang Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1392849

2,150 views
3 citations

Original Research

Published on 23 May 2024

Pharmacokinetic assessment of tacrolimus in combination with deoxyschizandrin in rats

in Drug Metabolism and Transport

Jianguo Sun
Zhipeng Wang
Na Liu
Zhijun Liu
Lili Cui
Xia Tao
Wansheng Chen
Shouhong Gao
Zhijun Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1344369

2,259 views

Original Research

Published on 22 May 2024

Simultaneous determination of multiple components in rat plasma by UPLC-MS/MS for pharmacokinetic studies after oral administration of Pogostemon cablin extract

in Drug Metabolism and Transport

Yameng Zhu
Huizi Ouyang
Zhenguo Lv
Guangzhe Yao
Minglei Ge
Xiunan Cao
Yanxu Chang
Jun He

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1293464

2,303 views
1 citation

Clinical Trial

Published on 17 May 2024

A single-dose, randomized, open-label, four-period, crossover equivalence trial comparing the clinical similarity of the proposed biosimilar rupatadine fumarate to reference Wystamm® in healthy Chinese subjects

in Drug Metabolism and Transport

Sisi Lin
Yutao Lou
Rui Hao
Yiming Shao
Jin Yu
Lu Fang
Meihua Bao
Wu Yi
Yiwen Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1328142

2,342 views
13 citations

Original Research

Published on 16 May 2024

Modulation of the photobehavior of gefitinib and its phenolic metabolites by human transport proteins

in Drug Metabolism and Transport

Lorena Tamarit
Meryem El Ouardi
Emilio Lence
Inmaculada Andreu
Concepcion González-Bello
Miguel A. Miranda
Ignacio Vayá

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1387057

1,505 views

Original Research

Published on 10 May 2024

The cardiovascular toxicity of polystyrene microplastics in rats: based on untargeted metabolomics analysis

in Drug Metabolism and Transport

Zikai Song
Haidi Wu
Xiaoqi Fang
Xuemin Feng
Liting Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1336369

5,623 views
18 citations

Original Research

Published on 09 May 2024

Improving prediction of tacrolimus concentration using a combination of population pharmacokinetic modeling and machine learning in chinese renal transplant recipients

in Drug Metabolism and Transport

Yu-Ping Wang
Xiao-Ling Lu
Kun Shao
Hao-Qiang Shi
Pei-Jun Zhou
Bing Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1389271

3,131 views
5 citations

Review

Published on 07 May 2024

Advancements and challenges in pharmacokinetic and pharmacodynamic research on the traditional Chinese medicine saponins: a comprehensive review

in Drug Metabolism and Transport

Yuhan Ma
Yongxia Zhao
Mingxia Luo
Qin Jiang
Sha Liu
Qi Jia
Zhixun Bai
Faming Wu
Jian Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1393409

6,210 views
17 citations