Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 20 Sep 2024

Metabolomics and network pharmacology reveal partial insights into the hypolipidemic mechanisms of ferulic acid in a dyslipidemia mouse model

in Drug Metabolism and Transport

Zhihao Zeng
Guanlin Xiao
Yanchang Liu
Minshan Wu
Xingqin Wei
Canhui Xie
Guangying Wu
Dezheng Jia
Yangxue Li
Sumei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1466114

2,327 views

Methods

Published on 20 Sep 2024

A validated UPLC-MS/MS method for quantification of pyrotinib and population pharmacokinetic study of pyrotinib in HER2-positive breast cancer patients

in Drug Metabolism and Transport

Yunfang Zhu
Yuxiang Xu
Haopeng Zhao
Hongxin Qie
Xiaonan Gao
Jinglin Gao
Zhangying Feng
Jing Bai
Rui Feng
Mingxia Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1432944

1,660 views

Review

Published on 19 Sep 2024

Isoniazid-historical development, metabolism associated toxicity and a perspective on its pharmacological improvement

in Drug Metabolism and Transport

Jishnu Sankar
Anjali Chauhan
Ramandeep Singh
Dinesh Mahajan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1441147

6,852 views
9 citations

Original Research

Published on 18 Sep 2024

Analysis of riociguat and desmethyl riociguat by UPLC-MS/MS and its interaction with quercetin

in Drug Metabolism and Transport

Qingqing Li
Xiaohai Chen
Siping Zhang
Wanshu Li
Hangjuan Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1470377

1,522 views

Original Research

Published on 13 Sep 2024

Quantitative pulmonary pharmacokinetics of tetrandrine for SARS-CoV-2 repurposing: a physiologically based pharmacokinetic modeling approach

in Drug Metabolism and Transport

Furun Wang
Liuhan Dong
Juanwen Hu
Shijie Yang
Lingchao Wang
Zhiwei Zhang
Wenpeng Zhang
Xiaomei Zhuang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1457983

1,773 views

Original Research

Published on 12 Sep 2024

Inhibitory effects of calcium channel blockers nisoldipine and nimodipine on ivacaftor metabolism and their underlying mechanism

in Drug Metabolism and Transport

Hailun Xia
Xinhao Xu
Jie Chen
Hualu Wu
Yuxin Shen
Xiaohai Chen
Ren-ai Xu
Wenzhi Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1403649

2,090 views

Original Research

Published on 06 Sep 2024

Exploring pharmacokinetic variability of palbociclib in HR+/HER2- metastatic breast cancer: a focus on age, renal function, and drug–gene interactions

in Drug Metabolism and Transport

Elena Peruzzi
Bianca Posocco
Lorenzo Gerratana
Margherita Nuti
Marco Orleni
Sara Gagno
Elena De Mattia
Fabio Puglisi
Erika Cecchin
Giuseppe Toffoli

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1420174

2,229 views
3 citations

Original Research

Published on 26 Aug 2024

Preclinical pharmacokinetic studies and prediction of human PK profiles for Deg-AZM, a clinical-stage new transgelin agonist

in Drug Metabolism and Transport

Xiaoting Gu
Xiaohe Li
Weixue Tian
Chaoyue Zheng
Yutian Cai
Xiang Xu
Conglu Zhao
Hongting Liu
Yao Sun
Zhilin Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423175

2,157 views
1 citation

Original Research

Published on 26 Aug 2024

In vitro mechanistic study on mycophenolate mofetil drug interactions: effect of prednisone, cyclosporine, and others

in Drug Metabolism and Transport

Junjun Mao
Feifei Yu
Weiwei Qin
Guixian She
Yi Rong
Zhuohan Hu
Mingkang Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1443794

2,515 views
1 citation

Original Research

Published on 23 Aug 2024

Population pharmacokinetics study of tacrolimus in liver transplant recipients: a comparison between patients with or without liver cancer before surgery

in Drug Metabolism and Transport

Haihong Bai
Juping Yun
Zihe Wang
Yingmin Ma
Wei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1449535

1,817 views

Original Research

Published on 23 Aug 2024

Enhanced anti-inflammatory activity of chlorogenic acid via folic acid-TPGS-modified liposomes encapsulation: characterization and In vivo evaluation on colitis mice

in Drug Metabolism and Transport

Qing-qing Li
Jia-hui Yan
Zhi-e Zhou
Xiang Geng
Jian-hua Xiong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1437773

2,096 views
3 citations

Original Research

Published on 21 Aug 2024

The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity

in Drug Metabolism and Transport

Godefridus J. Peters
Ietje Kathmann
Elisa Giovannetti
Kees Smid
Yehuda G. Assaraf
Gerrit Jansen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1450418

3,363 views
1 citation

Original Research

Published on 20 Aug 2024

Effects of three flavonoids on the metabolism of lenvatinib

in Drug Metabolism and Transport

Jinzhao Yang
Jie Chen
Qingqing Li
Ren-ai Xu
Xiaohai Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1438259

1,815 views
1 citation

Original Research

Published on 20 Aug 2024

Influence of C-reactive protein on the pharmacokinetics of voriconazole in relation to the CYP2C19 genotype: a population pharmacokinetics analysis

in Drug Metabolism and Transport

Jing Ling
Xuping Yang
Lulu Dong
Yan Jiang
Sulan Zou
Nan Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1455721

2,009 views
1 citation

Original Research

Published on 16 Aug 2024

A simple HPLC–MS/MS method for the determination of polymyxin B in human plasma and its application in the pharmacokinetic study in elderly patients infected with multidrug-resistant Gram-negative bacteria

in Drug Metabolism and Transport

Sheng Hu
Nan Guo
Juan Zeng
Yue Li
Yahui Zhang
Jinjiao Jiang
Bing Leng
Chengwu Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1396307

3,167 views

Review

Published on 12 Aug 2024

Potential role of endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity-an update

in Drug Metabolism and Transport

Mingli Sun
Xin Zhang
Boxuan Tan
Qingya Zhang
Xiaopeng Zhao
Dan Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1415108

3,528 views
12 citations