Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 27 Mar 2024

Clinical and pharmacological factors influencing serum clozapine and norclozapine levels

in Drug Metabolism and Transport

Anna Mach
Anna Wnorowska
Marcin Siwek
Marcin Wojnar
Maria Radziwoń-Zaleska

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1356813

3,211 views
4 citations

Original Research

Published on 25 Mar 2024

Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice

in Drug Metabolism and Transport

Heechun Kwak
Min-Soo Kim
Suyong Kim
Jiyoung Kim
Yasunori Aoki
Suk-Jae Chung
Hyun-Ja Nam
Wooin Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1352842

2,792 views
1 citation

Original Research

Published on 18 Mar 2024

Application of machine learning combined with population pharmacokinetics to improve individual prediction of vancomycin clearance in simulated adult patients

in Drug Metabolism and Transport

Guodong Li
Yubo Sun
Liping Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1352113

2,779 views
5 citations

Mini Review

Published on 13 Mar 2024

Emerging therapeutic drug monitoring technologies: considerations and opportunities in precision medicine

in Drug Metabolism and Transport

Winnie S. Liang
Brett Beaulieu-Jones
Susan Smalley
Michael Snyder
Laura H. Goetz
Nicholas J. Schork

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1348112

9,051 views
14 citations

Original Research

Published on 11 Mar 2024

Establishment of a pharmacokinetics and pharmacodynamics model of Schisandra lignans against hippocampal neurotransmitters in AD rats based on microdi-alysis liquid chromatography-mass spectrometry

in Drug Metabolism and Transport

Jinpeng Zhang
Xinyuan Cui
Shuo Zhao
Zenghui Chang
Junshuo Zhang
Yufeng Chen
Jiale Liu
Guohao Sun
Yiyuan Wang
Yuanyuan Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1342121

2,521 views
2 citations

Original Research

Published on 11 Mar 2024

Potential pharmacological mechanisms of tanshinone IIA in the treatment of human neuroblastoma based on network pharmacological and molecular docking Technology

in Drug Metabolism and Transport

Ning Tang
Yan Wang
Jiarui Miao
Yang Zhao
Yue Cao
Wentao Sun
Jingke Zhang
Hua Sui
Bing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1363415

4,011 views
4 citations

Original Research

Published on 04 Mar 2024

Exploring inter-ethnic and inter-patient variability and optimal dosing of osimertinib: a physiologically based pharmacokinetic modeling approach

in Drug Metabolism and Transport

Feng Liang
Yimei Zhang
Qian Xue
Na Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1363259

2,149 views
4 citations

Original Research

Published on 04 Mar 2024

Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors

in Drug Metabolism and Transport

Xiaoqing Li
Yunhai Bo
Qingping Zeng
Lei Diao
Stephanie Greene
John Patterson
Lu Liu
Fen Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1322557

2,529 views
8 citations

Original Research

Published on 01 Mar 2024

Optimization and preparation of a compound cod liver oil film former agent: an orthogonal design

in Drug Metabolism and Transport

Yao He
Ying Zhang
Zheng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1296448

2,494 views
2 citations

Review

Published on 20 Feb 2024

A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis

in Drug Metabolism and Transport

Nour Ayoub
Antoine Gedeon
Hélène Munier-Lehmann

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1329011

10,122 views
15 citations

Original Research

Published on 20 Feb 2024

Ivacaftor pharmacokinetics and lymphatic transport after enteral administration in rats

in Drug Metabolism and Transport

Jiří Pozniak
Pavel Ryšánek
David Smrčka
Petr Kozlík
Tomáš Křížek
Jaroslava Šmardová
Anežka Nováková
Debanjan Das
Daniel Bobek
Mahak Arora

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1331637

3,131 views
4 citations

Original Research

Published on 08 Feb 2024

Herb-drug interactions of silybinin and cilofexor in beagle dogs based on pharmacokinetics by UPLC-MS/MS

in Drug Metabolism and Transport

Xinyi Wei
Yanding Su
Qian Cheng
Songmao Liang
Tingping Zhang
Lengxin Duan
Xiuwei Shen
Xiangjun Qiu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1334402

1,945 views
1 citation

Clinical Trial

Published on 26 Jan 2024

Pharmacokinetics, pharmacodynamics and safety of 15 mg-tolvaptan administered orally for 7 consecutive days to Chinese patients with child-Pugh B cirrhosis

in Drug Metabolism and Transport

Hongzhong Liu
Yongfeng Wang
Tao Liu
Yingxuan Chen
Xin Zheng
Ming Liu
Qian Zhao
Minde Zeng
Ji Jiang
Yimin Mao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1324299

2,721 views

Original Research

Published on 26 Jan 2024

Exploration of biomarkers for efficacy evaluation of traditional Chinese medicine syndromes of acute exacerbation of chronic obstructive pulmonary disease based on metabolomics

in Drug Metabolism and Transport

Zhang Hailong
Si Yimei
Du Yan
Liu Xinguang
Li Jiansheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1302950

4,351 views
8 citations

Editorial

Published on 25 Jan 2024

Editorial: Drug metabolism-induced organ toxicity

in Drug Metabolism and Transport

Adnan A. Kadi
Yang Li
Abhinav Parashar
Mohamed W. Attwa

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1362229

2,457 views

Review

Published on 16 Jan 2024

Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing

in Drug Metabolism and Transport

Lin Zhao
Jiamei Chen
Bai Bai
Guili Song
Jingwen Zhang
Han Yu
Shiwei Huang
Zhang Wang
Guanghua Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1333986

22,494 views
37 citations