Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 27 Feb 2025

Melatonin protects retinal pigment epithelium cells against ferroptosis in AMD via the PI3K/AKT/MDM2/P53 pathway

in Experimental Pharmacology and Drug Discovery

Ping Wu
Long Zhao
Yong Du
Jing Lu
Yuxia He
Qinxin Shu
Hui Peng
Xing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543575

2,111 views

Original Research

Published on 26 Feb 2025

A combinatorial screening protocol for identifying novel and highly potent dual-target inhibitor of BRD4 and STAT3 for kidney cancer therapy

in Experimental Pharmacology and Drug Discovery

Shizhu Zhang
Nan Wu
Yifei Geng
Lixia Guan
Miao-Miao Niu
Jindong Li
Lusha Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560559

1,331 views

Original Research

Published on 26 Feb 2025

High-performance PBPK model for predicting CYP3A4 induction-mediated drug interactions: a refined and validated approach

in Experimental Pharmacology and Drug Discovery

Cheng-Guang Yang
Tao Chen
Wen-Teng Si
An-Hai Wang
Hong-Can Ren
Li Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1521068

1,219 views

Original Research

Published on 26 Feb 2025

Microbiota and metabolomic profiling coupled with machine learning to identify biomarkers and drug targets in nasopharyngeal carcinoma

in Experimental Pharmacology and Drug Discovery

Junsong Liu
Chongwen Xu
Rui Wang
Jianhua Huang
Ruimin Zhao
Rui Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551411

1,133 views

Original Research

Published on 25 Feb 2025

Significance of LRFN4 in prognosis and tumor microenvironment of lung adenocarcinoma

in Experimental Pharmacology and Drug Discovery

Nana Wang
Shuming Cao
Xiaofeng Tan
Meirong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1540636

1,043 views

Original Research

Published on 25 Feb 2025

Identification of telomere-related gene subtypes and prognostic signatures in osteosarcoma

in Experimental Pharmacology and Drug Discovery

Zhaoguang Song
Wenyan Yu
Xuqing Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545913

795 views

Review

Published on 25 Feb 2025

Exploring manzamine a: a promising anti-lung cancer agent from marine sponge Haliclona sp

in Experimental Pharmacology and Drug Discovery

Min Su
Jie Zhu
Luyuan Bai
Yu Cao
Shaohui Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1525210

1,285 views
1 citation

Original Research

Published on 25 Feb 2025

Deciphering the role of Wnt/β-catenin and miR-214 in knee osteoarthritis: molecular and clinical insights

in Experimental Pharmacology and Drug Discovery

Waad A. Samman
Esraa M. Mosalam
Dalia S. Saif
Mahmoud S. Abdallah
Abdel-Aziz A. Zidan
Amany Said Sallam
Shimaa Abdelsattar
Fatma Omar Khalil
Amany E. Elashkar
Somia Mokabel Mohamed

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1507693

1,001 views

Original Research

Published on 25 Feb 2025

Targeting TRPV1 channels in desensitized neural afferent pathways may help mitigate pain and lower urinary tract symptoms caused by prostatitis

in Experimental Pharmacology and Drug Discovery

ZhiPeng Jiang
AnGuo Li
Wen Luo
XiKe Luo
DeCan Liang
Jing Li
KaiHua Tang
Lei Liu
ZongMin Long
Ruiyu Miao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541684

1,138 views

Original Research

Published on 21 Feb 2025

MFAP4 is a novel prognostic biomarker in glioma correlating with immunotherapy resistance and ferroptosis

in Experimental Pharmacology and Drug Discovery

Yuanhao Lv
Ying Gao
Wenyu Di
Zhaoyi Li
Yashen Shi
Tianyuan Hou
Yiyang Chen
Jiaqi Tian
Miaoming Xu
Wei Su

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551863

1,645 views
2 citations

Original Research

Published on 20 Feb 2025

The lower rate of bone and joint infection in patients with open extremity fractures associated with vaccination prior to injury: a propensity-matched cohort study

in Experimental Pharmacology and Drug Discovery

Wencheng Hu
Saiyu Shi
Junqing Lin
Tao Gao
Junjie Shen
Yi Sun
Haifeng Wei
Xianyou Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546191

911 views

Brief Research Report

Published on 19 Feb 2025

The clinically applied PARP inhibitor talazoparib ameliorates imiquimod-induced psoriasis in mice without reducing skin inflammation

in Experimental Pharmacology and Drug Discovery

Petra Molnár
Máté Ágoston Demény
Beáta Várkonyi
Zsuzsanna Polgár
Ágnes Pór
Ilona Kovács
Andrea Szegedi
Attila Gábor Szöllősi
Magdolna Szántó

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519066

1,225 views

Original Research

Published on 19 Feb 2025

Harnessing machine learning and AI-driven analytics to identify novel drug targets and predict chemotherapy efficacy in NSCLC

in Experimental Pharmacology and Drug Discovery

Shaojia Qin
Biyu Deng
Dan Mo
Zhengyou Zhang
Xuan Wei
Zhougui Ling

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1555040

1,227 views

Original Research

Published on 19 Feb 2025

Potential efficacy and mechanisms of icariin for the animal model of osteonecrosis of the femoral head

in Experimental Pharmacology and Drug Discovery

Jie Xu
Wei Deng
Xun Zhu
Deyu Han
Yu Zheng
Qun Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1508971

926 views

Original Research

Published on 18 Feb 2025

Mechanism of PAVA-induced toxicity and inflammation in a cocultured skin cell model

in Experimental Pharmacology and Drug Discovery

Yunyang Song
Wenjie Cheng
Zhen Wang
Tianqi Zhou
Fanghui Wu
Yifeng Yin
Dan Xu
Yanli Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531459

816 views

Original Research

Published on 18 Feb 2025

Brigatinib can inhibit proliferation and induce apoptosis of human immortalized keratinocyte cells

in Experimental Pharmacology and Drug Discovery

Qi Yang
Dan Zhao
Linjie Ju
Peng Cao
Jifu Wei
Zhixian Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524277

1,683 views