Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 13 Nov 2024

Integration of metabolomics and transcriptomics to reveal anti-immunosuppression mechanism of Lycium barbarum polysaccharide

in Experimental Pharmacology and Drug Discovery

Jiandong Wang
Xue Zhang
Yi Wu
Qianfei Wei
Lingshan Yan
Youli Yu
Yanan Guo
Zhengqin Yu
Pan Wang
Xiaonan Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486739

1,368 views

Original Research

Published on 13 Nov 2024

Herbal formula xuling-jiangu improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the gut-bone axis

in Experimental Pharmacology and Drug Discovery

Juan Chen
Szetuen Ng
Pengchao Xu
Sainan Chen
Shengqiang Li
Xuan Chen
Lihua Xie
Jirong Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505231

1,569 views

Original Research

Published on 12 Nov 2024

Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): in vivo and in vitro evaluation

in Experimental Pharmacology and Drug Discovery

Jie Wen
Lingmao Zhao
Zhuohan Li
Chao Pi
Xianhu Feng
Peng Shi
Hongru Yang
Ligang Chen
Xiaodong Wang
Furong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1464626

1,101 views
1 citation

Original Research

Published on 12 Nov 2024

Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide

in Experimental Pharmacology and Drug Discovery

Dayma Llanes
Robert Rennert
Paul Jänicke
Ibrahim Morgan
Leslie Reguera
Daniel G. Rivera
Manuel G. Ricardo
Ludger A. Wessjohann

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1408091

1,282 views

Original Research

Published on 11 Nov 2024

Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation

in Experimental Pharmacology and Drug Discovery

Gaetano Marverti
Maria Gaetana Moschella
Alice Belardo
Michele Lamesta
Giada Mercanile
Lorenzo Tagliazucchi
Daniele Aiello
Alberto Venturelli
Davide Illuminati
Remo Guerrini

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1477318

1,243 views
1 citation

Original Research

Published on 11 Nov 2024

Nanotechnological prospective for enhancing the antibacterial activity of mupirocin and cinnamon essential oil: a combination therapy

in Experimental Pharmacology and Drug Discovery

Bandar Aldhubiab
Rashed M. Almuqbil
Tamer M. Shehata
Wafaa E. Soliman
Heba S. Elsewedy

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1468374

1,036 views

Original Research

Published on 06 Nov 2024

Structure-guided drug repurposing identifies aristospan as a potential inhibitor of β-lactamase: insights from virtual screening and molecular dynamics simulations

in Experimental Pharmacology and Drug Discovery

Moyad Shahwan
Mohd Shahnawaz Khan
Azna Zuberi
Nojood Altwaijry
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1459822

1,094 views

Mini Review

Published on 06 Nov 2024

Recent advances in extracellular matrix manipulation for kidney organoid research

in Experimental Pharmacology and Drug Discovery

Ren Wang
Yufei Sui
Qiuyan Liu
Yucui Xiong
Shanshan Li
Wu Guo
Yiwei Xu
Sheng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1472361

2,147 views
1 citation

Original Research

Published on 06 Nov 2024

Berberine ameliorates septic cardiomyopathy through protecting mitochondria and upregulating Notch1 signaling in cardiomyocytes

in Experimental Pharmacology and Drug Discovery

Qi Shen
Yufan Yuan
Zelin Li
Ying Ling
Jian Wang
Mingjing Gao
Peng Wang
Mengli Li
Lizhong Lai
Jinlan Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1502354

2,118 views
4 citations

Original Research

Published on 06 Nov 2024

Yigu decoction regulates plasma miRNA in postmenopausal osteoporosis patients: a randomized controlled trial

in Experimental Pharmacology and Drug Discovery

Haifeng Chen
Ruikun Zhang
Guijin Li
Kun Yan
Ziqi Wu
Yang Zhang
Zhineng Chen
Xinmiao Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1460906

1,754 views

Original Research

Published on 05 Nov 2024

Exploring the mechanism of sesamin for the treatment of PM2.5-induced cardiomyocyte damage based on transcriptomics, network pharmacology and experimental verification

in Experimental Pharmacology and Drug Discovery

Yadong Zhang
Rui Wen
Jingyi Ren
Fan Zhang
Huanting Pei
Jinshi Zuo
Yuxia Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486563

1,822 views

Review

Published on 01 Nov 2024

Advances of curcumin in nervous system diseases: the effect of regulating oxidative stress and clinical studies

in Experimental Pharmacology and Drug Discovery

Yuxun Wei
Hong Li
Yue Li
Yue Zeng
Tian Quan
Yanen Leng
En Chang
Yingtao Bai
Yuan Bian
Yi Hou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1496661

3,532 views
8 citations

Systematic Review

Published on 01 Nov 2024

Efficacy of different traditional Chinese medicine decoctions in the treatment of ischemic stroke: a network meta-analysis

in Experimental Pharmacology and Drug Discovery

Baicheng Ning
Xiaoting Zhu
Xiaodong Wu
Weiyao Zhu
Runze Wang
Chang Qi
Mingquan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486458

2,995 views
3 citations

Original Research

Published on 01 Nov 2024

D-mannose reduces oxidative stress, inhibits inflammation, and increases treg cell proportions in mice with ulcerative colitis

in Experimental Pharmacology and Drug Discovery

Yuqing Lu
Yongjian Xiong
Shuangshuang Zhang
Boya Wang
Yuntao Feng
Zhuonan Pu
Kun Wei
Jun Chen
Dapeng Chen
Peng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1454713

2,661 views
4 citations

Original Research

Published on 31 Oct 2024

Protective effect of baicalin on oxidative stress injury in retinal ganglion cells through the JAK/STAT signaling pathway in vitro and in vivo

in Experimental Pharmacology and Drug Discovery

Huan Yu
Dan Zhou
Wei Wang
Qingxia Wang
Min Li
Xiaoyun Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1443472

2,048 views
1 citation

Original Research

Published on 31 Oct 2024

Isatin improves oligoasthenospermia caused by busulfan by regulating GSH/GPX4 axis to inhibit ferroptosis

in Experimental Pharmacology and Drug Discovery

Chengniu Wang
Weizhen Wang
Jin Dong
Xiaoran Li
Taowen Ye
Fanshuo Zeng
Mingyu Jiang
Jianwu Shi
Xiaorong Wang
Lei Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1489956

2,097 views