Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 23 Oct 2024

Antimutagenic and anticoagulant therapeutic effects of Ag/Ag2O nanoparticles from Olea europaea leaf extract: mitigating metribuzin-induced hepato-and nephrotoxicity

in Experimental Pharmacology and Drug Discovery

Manel Azzi
Ibtissam Laib
Abderrhmane Bouafia
Ifriqya Medila
Ali Tliba
Salah Eddine Laouini
Huda Alsaeedi
David Cornu
Mikhael Bechelany
Ahmed Barhoum

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1485525

2,108 views

Opinion

Published on 23 Oct 2024

The enigma of small heat shock protein phosphorylation

in Experimental Pharmacology and Drug Discovery

Matthias Gaestel

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486245

903 views

Original Research

Published on 23 Oct 2024

De novo design of mIDH1 inhibitors by integrating deep learning and molecular modeling

in Experimental Pharmacology and Drug Discovery

Dingkang Sun
Lulu Xu
Mengfan Tong
Zhao Wei
Weitong Zhang
Jialong Liang
Xueying Liu
Yuwei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1491699

1,267 views

Original Research

Published on 23 Oct 2024

Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond

in Experimental Pharmacology and Drug Discovery

Ting Tai
Yuan-Yuan Shao
Yu-Qi Zheng
Li-Ping Jiang
Hao-Ru Han
Na Yin
Hao-Dong Li
Jin-Zi Ji
Qiong-Yu Mi
Li Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1496639

3,709 views
2 citations

Original Research

Published on 22 Oct 2024

Exploring the antioxidant and protective effects of Marsdenia thyrsiflora Hook.f. leaf extract against carbon tetrachloride-induced hepatic damage in rat models

in Experimental Pharmacology and Drug Discovery

Sushmita Saha
Abdulrahman Alshammari
Norah A. Albekairi
Tasniya Nahiyan Zulfiquar
Md Salman Shakil
Kakoli Rani Mondal
Milton Kumar Kundu
Milon Mondal
Mohammad S. Mubarak

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1463922

1,348 views
1 citation

Original Research

Published on 22 Oct 2024

Sodium danshensu modulates skeletal muscle fiber type formation and metabolism by inhibiting pyruvate kinase M1

in Experimental Pharmacology and Drug Discovery

Yunxia Zhang
Xiaoxiao Wu
Ruoqi Li
Mengru Sui
Guoyin Li
Shuhua Fan
Mingsheng Yang
Qiuping Liu
Xiaomeng Liu
Changjing Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1467620

1,851 views
1 citation

Original Research

Published on 22 Oct 2024

PACAP38 synergizes with irradiation to suppress the proliferation of multiple cancer cells via regulating SOX6/Wnt/β-catenin signaling

in Experimental Pharmacology and Drug Discovery

Ran Wu
Chun-Xiang Cao
Lu Cao
Jun Su
Ke-Man Liao
Huan Li
Qian Zhu
Shu-Yan Li
Min Li
Jia-Yi Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1492453

1,863 views

Original Research

Published on 22 Oct 2024

Exploring the effects of moxibustion on cognitive function in rats with multiple cerebral infarctions from the perspective of glial vascular unit repairing

in Experimental Pharmacology and Drug Discovery

Jingji Wang
Kunrui Du
Chang Liu
Xiaoyu Chen
Wenming Ban
Guoqi Zhu
Jun Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1428907

2,457 views
3 citations

Original Research

Published on 21 Oct 2024

Design, synthesis, and biological evaluation of 2,4-dimorpholinopyrimidine-5-carbonitrile derivatives as orally bioavailable PI3K inhibitors

in Experimental Pharmacology and Drug Discovery

Daowei Huang
Jixia Yang
Qingwei Zhang
Xiaolei Zhou
Yanbo Wang
Zhenhua Shang
Jianqi Li
Baoyin Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1467028

1,937 views
1 citation

Correction

Published on 16 Oct 2024

Corrigendum: Combination of rapamycin and MK-2206 induced cell death via autophagy and necroptosis in MYCN-amplified neuroblastoma cell lines

in Experimental Pharmacology and Drug Discovery

Yudi Dong
Wei Gong
Zhongyan Hua
Bo Chen
Guifeng Zhao
Zhihui Liu
Carol J. Thiele
Zhijie Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1425039

748 views

Original Research

Published on 16 Oct 2024

Apoptotic and proliferative processes in the small intestine of rats with type 2 diabetes mellitus after metformin and propionic acid treatment

in Experimental Pharmacology and Drug Discovery

Larysa Natrus
Olha Lisakovska
Anton Smirnov
Yuliia Osadchuk
Yuliia Klys

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1477793

1,165 views

Editorial

Published on 16 Oct 2024

Editorial: Modulation of immune function: drug discovery and translational application

in Experimental Pharmacology and Drug Discovery

Ruirong Tan
Junning Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1495815

644 views

Original Research

Published on 16 Oct 2024

Family Malvaceae: a potential source of secondary metabolites with chemopreventive and anticancer activities supported with in silico pharmacokinetic and pharmacodynamic profiles

in Experimental Pharmacology and Drug Discovery

Salma Sameh
Ahmed M. Elissawy
Eman Al-Sayed
Rola M. Labib
Hsueh-Wei Chang
Szu-Yin Yu
Fang-Rong Chang
Shyh-Chyun Yang
Abdel Nasser B. Singab

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1465055

5,254 views
3 citations

Correction

Published on 16 Oct 2024

Corrigendum: An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis

in Experimental Pharmacology and Drug Discovery

Alexander Vugler
James O’connell
Mai Anh Nguyen
Dietmar Weitz
Thomas Leeuw
Elizabeth Hickford
Alexander Verbitsky
Xiaoyou Ying
Markus Rehberg
Bruce Carrington

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1479557

1,559 views

Original Research

Published on 15 Oct 2024

The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair

in Experimental Pharmacology and Drug Discovery

Xian Wang
Yuetong Wang
Xianglin Zeng
Haoyu Lu
Dongqin Mo
Yuetao Li
Zhiqing Liu
Yude Huang
Kun Yu
Daiyou Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1471996

983 views

Original Research

Published on 14 Oct 2024

Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis

in Experimental Pharmacology and Drug Discovery

Ruiqiang Xie
Hongyan Xie
Hong Gao
Chunguang Xie
Haipo Yuan
Zhijun Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1448505

2,982 views
4 citations