Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 11 Jun 2024

Evaluation of the synergistic effects of curcumin-resveratrol co-loaded biogenic silica on colorectal cancer cells

in Experimental Pharmacology and Drug Discovery

Adriana Ochoa-Sanchez
Padmavati Sahare
Surajit Pathak
Antara Banerjee
Miriam Estevez
Asim K. Duttaroy
Gabriel Luna-Bárcenas
Sujay Paul

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1341773

3,280 views
6 citations

Original Research

Published on 11 Jun 2024

Deciphering the therapeutic potential of trimetazidine in rheumatoid arthritis via targeting mi-RNA128a, TLR4 signaling pathway, and adenosine-induced FADD-microvesicular shedding: In vivo and in silico study

in Experimental Pharmacology and Drug Discovery

Enas Omran
Abdullah R. Alzahrani
Samar F. Ezzat
Ghada Ellithy
Marwa Tarek
Eman Khairy
Mohamed M. Ghit
Ahmed Elgeushy
Tahani Mohamed Ibrahim Al-Hazani
Ibrahim Abdel Aziz Ibrahim

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1406939

2,679 views
1 citation

Original Research

Published on 10 Jun 2024

Sputum microbe community alterations induced by long-term inhaled corticosteroid use are associated with airway function in chronic obstructive pulmonary disease patients based on metagenomic next-generation sequencing (mNGS)

in Experimental Pharmacology and Drug Discovery

Yuanyi Yue
Baohui Zhang
Zhong He
Yuling Zheng
Xueqing Wang
Qiang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1323613

1,546 views

Review

Published on 07 Jun 2024

Improving the treatment of bacterial infections caused by multidrug-resistant bacteria through drug repositioning

in Experimental Pharmacology and Drug Discovery

Paulina Glajzner
Agnieszka Bernat
Magdalena Jasińska-Stroschein

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1397602

3,826 views
7 citations

Original Research

Published on 07 Jun 2024

Pre-clinical studies comparing the anti-inflammatory potential of artemisinic compounds by targeting NFκB/TNF-α/NLRP3 and Nrf2/TRX pathways in Balb/C mice

in Experimental Pharmacology and Drug Discovery

Syeda Tayyaba Batool Kazmi
Humaira Fatima
Iffat Naz
Nosheen Kanwal
Ihsan-ul Haq

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1352827

2,021 views
2 citations

Mini Review

Published on 06 Jun 2024

The emerging role and clinicopathological significance of MFSD12 in cancer and lysosomal storage diseases

in Experimental Pharmacology and Drug Discovery

Liqiong Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1398320

1,582 views
3 citations

Review

Published on 04 Jun 2024

Exploring orphan GPCRs in neurodegenerative diseases

in Experimental Pharmacology and Drug Discovery

Devrim Öz-Arslan
Melis Yavuz
Beki Kan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1394516

4,896 views
2 citations

Original Research

Published on 04 Jun 2024

The autophagic regulation of rosiglitazone-promoted adipocyte browning

in Experimental Pharmacology and Drug Discovery

Yue Li
Wanqing Zheng
Xinhang Li
Zhengwei Lue
Yun Liu
Jiaying Wu
Xiangnan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1412520

2,351 views
1 citation

Review

Published on 03 Jun 2024

Reflections on the regulatory field covering the development of paediatric medicinal products: a brief overview of current status and challenges

in Experimental Pharmacology and Drug Discovery

Birka Lehmann

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1375988

6,059 views

Original Research

Published on 03 Jun 2024

The impact of abstinence from chronic alcohol consumption on the mouse striatal proteome: sex and subregion-specific differences

in Experimental Pharmacology and Drug Discovery

Brittnie-lee M. Duffus
David L. Haggerty
Emma H. Doud
Amber L. Mosley
Bryan K. Yamamoto
Brady K. Atwood

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1405446

1,444 views
4 citations

Review

Published on 03 Jun 2024

Kratom safety and toxicology in the public health context: research needs to better inform regulation

in Experimental Pharmacology and Drug Discovery

Jack E. Henningfield
Oliver Grundmann
Marilyn A. Huestis
Kirsten E. Smith

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1403140

10,196 views
10 citations

Review

Published on 30 May 2024

Re-evaluation of the cardioprotective effects of cannabinoids against ischemia-reperfusion injury according to the IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria

in Experimental Pharmacology and Drug Discovery

Anna Pędzińska-Betiuk
Eberhard Schlicker
Jolanta Weresa
Barbara Malinowska

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1382995

1,644 views

Original Research

Published on 28 May 2024

From petals to healing: consolidated network pharmacology and molecular docking investigations of the mechanisms underpinning Rhododendron arboreum flower’s anti-NAFLD effects

in Experimental Pharmacology and Drug Discovery

Nitish Singh Jangwan
Mausin Khan
Richa Das
Najla Altwaijry
Ahlam Mansour Sultan
Ruqaiyah Khan
Shakir Saleem
Mamta F. Singh

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1366279

3,106 views
5 citations

Original Research

Published on 28 May 2024

Protective effect of dexmedetomidine against delayed bone healing caused by morphine via PI3K/Akt mediated Nrf2 antioxidant defense system

in Experimental Pharmacology and Drug Discovery

Yani Lou
Linfang Zou
Zhenyu Shen
Jianwei Zheng
Yuanqu Lin
Zhe Zhang
XuanKuai Chen
Jun Pan
Xutong Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1396713

2,004 views
5 citations

Original Research

Published on 23 May 2024

Fragment-based virtual screening identifies novel leads against Plasmepsin IX (PlmIX) of Plasmodium falciparum: Homology modeling, molecular docking, and simulation approaches

in Experimental Pharmacology and Drug Discovery

Haider Thaer Abdulhameed Almuqdadi
Sumaiya Kifayat
Razique Anwer
Jihad Alrehaili
Mohammad Abid

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1387629

2,022 views
3 citations

Original Research

Published on 23 May 2024

Prevention of cyclophosphamide-induced immune suppression by polysaccharides from Apocynum venetum flowers via enhancing immune response, reducing oxidative stress, and regulating gut microbiota in mice

in Experimental Pharmacology and Drug Discovery

Qingchun Zhao
Jinmei Wang
Haiyang Liang
Wenjing Guo
Yanhai Chu
Lijun Liu
Wenyi Kang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1354794

2,224 views
10 citations