Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 09 May 2025

Target screening and optimization of candidate compounds for breast cancer treatment using bioinformatics and computational chemistry approaches

in Experimental Pharmacology and Drug Discovery

Jian Xu
Xue Li
Yiduo Jia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1467504

684 views

Review

Published on 09 May 2025

The role of ERK1/2 signaling in diabetes: pathogenic and therapeutic implications

in Experimental Pharmacology and Drug Discovery

Hanlin Xu
Tao Liu
Yanfen Dai
Na Li
Zhanqi Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1600251

666 views

Original Research

Published on 09 May 2025

CS-6-induced p62 accumulation exacerbates DNA damage in colorectal cancer

in Experimental Pharmacology and Drug Discovery

Yitong Gong
Menghan Dong
Xiaofei Feng
Naiyu Zhang
Xuehui Cui
Liushuyue Wang
Qi Qi
Chiu-fai Kuok
Qingling Jiang
Sixue Bi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1568339

731 views

Original Research

Accepted on 08 May 2025

Flavonoid-Mediated Biofilm Inhibition and Toxicological Evaluation of Atriplex laciniata Against Multidrug-Resistant MRSA

in Experimental Pharmacology and Drug Discovery

Bandar Almutairy

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577052

109 views

Original Research

Published on 08 May 2025

Mangiferin mitigates dexamethasone-induced insulin resistance in rats: insight into vascular dysfunction and hepatic steatosis

in Experimental Pharmacology and Drug Discovery

Abdullah Q. Alsaedi
Manar A. Nader
Dalia H. El-Kashef
Marwa E. Abdelmageed

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572758

963 views

Original Research

Published on 08 May 2025

Reduced abundance of Fusobacterium signifies cardiovascular benefits of sodium glucose cotransporter 2 inhibitor in type 2 diabetes: a single arm clinical trial

in Experimental Pharmacology and Drug Discovery

Shuhui Yang
Jiankun Deng
Xiaoxu Weng
Zhaojie Ma
Nie Lin
Yili Xiao
Rui Zuo
Yufei Hu
Canbin Zheng
Xiaoshan Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1600464

797 views

Original Research

Published on 08 May 2025

Investigation of Fructus sophorae extract’s therapeutic mechanism in atrophic vaginitis based on network pharmacology and experimental validation

in Experimental Pharmacology and Drug Discovery

Jiarui Zheng
Weiming Wang
Wenting Song
Yehao Zhang
Mingjiang Yao
Guangrui Wang
Zishan Huang
Feng Li
Junguo Ren
Li Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571976

951 views

Original Research

Accepted on 05 May 2025

Understanding the molecular basis of herbal medicines for cough variant asthma under the guidance of traditional herbal theories

in Experimental Pharmacology and Drug Discovery

Rui Liu
Jiaqi Yao
Yihang Sui
Yinnan Zhang
Seng Kho
Yingli Zhu
Ninghua Tan
Yinyin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594308

Original Research

Published on 02 May 2025

Gen-miR-5 derived from Gentianella acuta inhibits PFKP to prevent fibroblast activation and alleviate myocardial fibrosis

in Experimental Pharmacology and Drug Discovery

Hongyao Ge
Zhenyu Du
Weizhe Liu
Letian Wang
Junyang Li
Gaoshan Yang
Aiying Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578877

804 views

Original Research

Published on 02 May 2025

Synthesis, target analysis, and cerebroprotective effects of novel imide antioxidants via the Nrf2/HO-1 pathway in cerebral ischemia-reperfusion injury

in Experimental Pharmacology and Drug Discovery

Lili Huang
Yinqi Chen
Hua Zhou
Huihui Chen
Xiping Wu
Zhuochao Wu
Zhoudi Liu
Zhiwei Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1552717

621 views

Original Research

Published on 02 May 2025

Compatibility optimization of the traditional Chinese medicines ‘Eczema mixture’ based on back-propagation artificial neural network and non-dominated sorting genetic algorithm

in Experimental Pharmacology and Drug Discovery

Xin He
Zhijie Song
Yanqun Yang
Siqi Wu
Shuo Meng
Huanyu E
Hongfei Li
Guoyu Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1593783

977 views

Original Research

Published on 30 Apr 2025

Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells

in Experimental Pharmacology and Drug Discovery

Ye Yang
Jieyun Zhou
Qiaoying Lv
Qicheng Ni
Baichun Hu
Yulong Wang
Shuning Qu
Guoting Li
Wenjie Yang
Ruihua Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573032

1,157 views

Original Research

Published on 30 Apr 2025

Acrylamide and bisphenol A: two plastic additives increase platelet activation, via oxidative stress

in Experimental Pharmacology and Drug Discovery

C. F. Burgos
D. Méndez
S. Quintana
S. Gonkowski
A. Trostchansky
M. Alarcón

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526374

1,260 views

Review

Published on 30 Apr 2025

Advancing precision oncology with AI-powered genomic analysis

in Experimental Pharmacology and Drug Discovery

Ruby Srivastava

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591696

1,307 views

Original Research

Published on 29 Apr 2025

Quercetin in Shengxian Decoction exhibits anti-ferroptosis protective roles in a myocardial infarction model via targeting DPP4/ HMOX1, based on network pharmacology and molecular docking

in Experimental Pharmacology and Drug Discovery

Yuming Zhai
Jiamei Fu
Jianfei Yang
Yabin Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1583509

1,218 views

Original Research

Published on 29 Apr 2025

Wuling capsule alleviates hyperuricaemia and protects UA- injured HK-2 cells by regulating uric acid transporter proteins

in Experimental Pharmacology and Drug Discovery

Nan Li
Hongna Liu
Zhongxing Song
Rui Zhou
Zhishu Tang
Hongbo Xu
Xinbo Shi
Yanru Liu
Jian Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563676

1,198 views