Frontiers in Pharmacology | Neuropharmacology

Original Research

Published on 13 May 2025

Flunarizine as a potential repurposed drug for the serotonin transporter inhibition: an integrated approach for therapeutic development against major depressive disorder

in Neuropharmacology

Abdelbaset Mohamed Elasbali
Ahmed S. Ali
Taj Mohammad
Mohd Adnan
Anas Shamsi
Md. Imtaiyaz Hassan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1599297

1,118 views

Case Report

Published on 09 May 2025

Case report: Analysis of the efficacy and safety of anti-infectious treatment for brain abscess caused by oral anaerobes

in Neuropharmacology

Chunfang Tian
Jingxian Liu
Zhiyu Chen
Lixia Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1506879

960 views

Original Research

Published on 09 May 2025

Loss of expression and function of Gβγ by GNB1 encephalopathy-associated L95P mutation of the Gβ1 subunit

in Neuropharmacology

Haritha P. Reddy
Tal Keren-Raifman
Galit Tabak
Nathan Dascal
Daniel Yakubovich

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592012

1,314 views

Original Research

Published on 08 May 2025

Preventive beneficial effects of cannabidiol in a reserpine-induced progressive model of parkinsonism

in Neuropharmacology

Alvaro C. Lima
Vinicius S. Bioni
Marcela S. Becegato
Ywlliane Meier
Débora M. G. Cunha
Natan A. Aguiar
Narriman Gonçalves
Fernanda F. Peres
Antônio W. Zuardi
Jaime E. C. Hallak

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539783

1,725 views

Original Research

Published on 08 May 2025

Protective effects of AER-271 in acute-phase radiation-induced brain injury in rats: reduction of brain edema, inflammation, apoptosis and maintenance of blood-brain barrier integrity

in Neuropharmacology

Yaozu Xiong
Yifei Wang
Mingyue Li
Changhua Yu
Yusuo Tong
Xiaoting Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534729

884 views

Review

Published on 06 May 2025

Advances in the prevalence and treatment of depression for adolescents: a review

in Neuropharmacology

Chunyu Yin
Mengting Xu
Zhiyuan Zong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574574

1,708 views

Editorial

Published on 06 May 2025

Editorial: World No-Tobacco: effects of tobacco and nicotine on the brain

in Neuropharmacology

Isis Nem de Oliveira Souza
Graciela N. Balerio
Vijayapandi Pandy
Massimo Grilli
Gilda Angela Neves

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610178

1,400 views

Review

Published on 02 May 2025

1-Nitro-2-phenylethane: a promising phytoconstituent to modulate neuroinflammation and oxidative stress with repercussions on neurological and psychiatric disorders

in Neuropharmacology

Lucas Villar Pedrosa Silva Pantoja
Emily Christie Maia Fonseca
Fábio José Coelho Souza-Junior
Brenda Costa da Conceição
Sarah Viana Farias
Joyce Kelly R. da Silva
José Guilherme Soares Maia
Pedro Iuri Castro Silva
Jofre Jacob Silva Freitas
Rui Daniel Prediger

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1552295

1,091 views

Review

Published on 01 May 2025

Progress in the study of the effects of selective serotonin reuptake inhibitors (SSRIs) on the reproductive system

in Neuropharmacology

Yu Feng
Xiaoyan Qu
Hua Hao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567863

1,575 views

Original Research

Published on 30 Apr 2025

Region-specific neuroprotective effects of meldonium pretreatment in two models of sepsis-associated encephalopathy

in Neuropharmacology

Aleksandra Ružičić
Tijana Srdić
Katarina Bobić
Dunja Drakulić
Filip Veljković
Ana Todorović
Siniša Đurašević
Iva Lakić

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588831

1,030 views

Original Research

Published on 30 Apr 2025

Association of serum insulin-like growth factor-1 and adrenocorticotropic hormone therapeutic response in patients with infantile epileptic spasms syndrome

in Neuropharmacology

Ka-Na Lin
Feng Han
Ying-Yan Wang
Wei Zhao
Ji-Wen Wang
Hao Li
Yun-Qing Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1599641

807 views

Original Research

Published on 30 Apr 2025

Antidepressant-like activity of Bezafibrate in mice models of depression: a behavioral and neurobiological characterization

in Neuropharmacology

Dawei Xu
Jin Zhou
Siyi Zhou
Weizhen Wang
Chengniu Wang
Bo Jiang
Wei Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595341

1,157 views

Original Research

Published on 29 Apr 2025

Protective effect of brain microvascular endothelial cell-derived exosomes on blood-brain barrier induced by ischemia-reperfusion injury in vivo and in vitro

in Neuropharmacology

Jin Sun
Meng Wang
Lichen Guo
Yushuang Cao
Linlin Su
Shaoxia Wang
Lijuan Chai
Qing Yuan
Limin Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548122

1,302 views

Original Research

Published on 28 Apr 2025

Optimization of neuron-specific interfering peptides targeting GABAB receptor downregulation for proteolytic stability for conferring neuroprotection in a mouse model of cerebral ischemia

in Neuropharmacology

Mohammad Hleihil
Musadiq A. Bhat
Thomas Grampp
Dietmar Benke

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1576884

797 views

Review

Published on 28 Apr 2025

Potential therapeutic targets for ischemic stroke in pre-clinical studies: Epigenetic-modifying enzymes DNMT/TET and HAT/HDAC

in Neuropharmacology

Yurou Guo
Jing Li
Xiaodan Liu
Huang Ding
Wei Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571276

1,339 views

Mini Review

Published on 28 Apr 2025

The prospective approach for aptamers applied in the treatment and molecular diagnostics of ischemic stroke

in Neuropharmacology

Wenfeng Li
Junyi Wu
Zijian Hu
Jixuan Zhang
Guangming Ye
Fengling Luo
Zhikun Zeng
Yi Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1553337

1,169 views