Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 21 Aug 2024

Comprehensive hepatotoxicity prediction: ensemble model integrating machine learning and deep learning

in Predictive Toxicology

Muhammad Zafar Irshad Khan
Jia-Nan Ren
Cheng Cao
Hong-Yu-Xiang Ye
Hao Wang
Ya-Min Guo
Jin-Rong Yang
Jian-Zhong Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1441587

2,156 views
3 citations

Original Research

Published on 14 Aug 2024

Predicting non-chemotherapy drug-induced agranulocytosis toxicity through ensemble machine learning approaches

in Predictive Toxicology

Xiaojie Huang
Xiaochun Xie
Shaokai Huang
Shanshan Wu
Lina Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1431941

1,720 views
2 citations

Original Research

Published on 09 Aug 2024

Assessing the immunogenicity risk of salmon calcitonin peptide impurities using in silico and in vitro methods

in Predictive Toxicology

Brian J. Roberts
Aimee E. Mattei
Kristina E. Howard
James L. Weaver
Hao Liu
Sandra Lelias
William D. Martin
Daniela Verthelyi
Eric Pang
Katie J. Edwards

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1363139

4,261 views
3 citations

Original Research

Published on 24 Jul 2024

Treatment of an accident of imidacloprid poisoning

in Predictive Toxicology

Mei Zeng
Mengdi Shi
Xiangdong Jian
Laidong Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1421437

4,189 views

Original Research

Published on 17 Jul 2024

Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment

in Predictive Toxicology

Andreas H. Göller
Sandra Johanssen
Adam Zalewski
Verena Ziegler

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1415266

3,236 views
2 citations

Case Report

Published on 17 Jul 2024

Fatal hyperpyrexia caused by xylazine: a case report

in Predictive Toxicology

Ping Dai
Yanqing Chen
Xianqin Luo
Zhiqiang Zhou
Mengdi Shi
Aerbusili Genjiafu
Xiangdong Jian

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1437960

1,277 views
3 citations

Original Research

Published on 17 Jul 2024

Analysis of eplerenone in the FDA adverse event reporting system (FAERS) database: a focus on overall patient population and gender-specific subgroups

in Predictive Toxicology

Xin Guan
Yusi Yang
Xinru Li
Yue Feng
Jizhen Li
Xuewen Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1417951

3,067 views
3 citations

Original Research

Published on 12 Jul 2024

Protective effect of naringenin on cadmium chloride-induced renal injury via alleviating oxidative stress, endoplasmic reticulum stress, and autophagy in chickens

in Predictive Toxicology

Yaning Shi
Zhixin Gao
Bing Xu
Junbing Mao
Yue Wang
Zongping Liu
Jicang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1440877

2,161 views
3 citations

Original Research

Published on 20 Jun 2024

Toxicological safety assessment of a water extract of Lithocarpus litseifolius by a 90-day repeated oral toxicity study in rats

in Predictive Toxicology

Jinfeng Ma
Yujia Wei
Jingfeng Sun
Fang Tan
Penghe Liu
Guangqiu Qin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1385550

1,022 views
1 citation

Original Research

Published on 19 Jun 2024

Assessing genotoxic effects of chemotherapy agents by a robust in vitro assay based on mass spectrometric quantification of γ-H2AX in HepG2 cells

in Predictive Toxicology

Minmin Qu
Jia Chen
Bin Xu
Qinyun Shi
Shujing Zhao
Zhaoxia Wang
Zhi Li
Bo Ma
Hua Xu
Qinong Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1356753

1,981 views

Original Research

Published on 19 Jun 2024

Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion

in Predictive Toxicology

Abdulkarim Najjar
Jochen Kühnl
Daniela Lange
Camille Géniès
Carine Jacques
Eric Fabian
Anne Zifle
Nicola J. Hewitt
Andreas Schepky

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1421601

3,913 views
7 citations

Review

Published on 18 Jun 2024

A web-based scoping review assessing the influence of smoking and smoking cessation on antidiabetic drug meabolism: implications for medication efficacy

in Predictive Toxicology

Carlo Maria Bellanca
Egle Augello
Giulia Di Benedetto
Chiara Burgaletto
Anna Flavia Cantone
Giuseppina Cantarella
Renato Bernardini
Riccardo Polosa
the DiaSmokeFree Working Group
Agostino Di Ciaula

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1406860

5,822 views
2 citations

Original Research

Published on 13 Jun 2024

Involvement of autophagy in mesaconitine-induced neurotoxicity in HT22 cells revealed through integrated transcriptomic, proteomic, and m6A epitranscriptomic profiling

in Predictive Toxicology

Xiaohuang Lin
Jian Zhang
Zekai Wu
Yuan Shi
Mengting Chen
Maodong Li
Hong Hu
Kun Tian
Xiaoqi Lv
Chutao Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1393717

3,077 views
6 citations

Original Research

Published on 17 May 2024

Upregulation of GOLPH3 mediated by Bisphenol a promotes colorectal cancer proliferation and migration: evidence based on integrated analysis

in Predictive Toxicology

Lihua Chen
Shaojian Chen
Yachen Li
Yi Qiu
Xiaojing Chen
Yuze Wu
Xian Deng
Mingliang Chen
Chunxiao Wang
Zhongshi Hong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1337883

2,282 views

Original Research

Published on 09 May 2024

Delineation of renal protein profiles in aristolochic acid I-induced nephrotoxicity in mice by label-free quantitative proteomics

in Predictive Toxicology

Xinhui Liu
Shanshan Wu
Yu Peng
Liwen Gao
Xi Huang
Ruyu Deng
Jiandong Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1341854

1,908 views
1 citation

Original Research

Published on 10 Apr 2024

Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy

in Predictive Toxicology

James A. Coleman
Ruben Doste
Matteo Beltrami
Alessia Argirò
Raffaele Coppini
Iacopo Olivotto
Betty Raman
Alfonso Bueno-Orovio

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1379236

2,332 views
6 citations