Skip to main content

BRIEF RESEARCH REPORT article

Front. Psychiatry, 14 April 2021
Sec. Public Mental Health

Factor Structure of the Short-Form of Center for Epidemiological Studies Depression Scale for People With Physical Disabilities

  • Department of Secondary Special Education, College of Education, Jeonju University, Jeonju, South Korea

This study aimed to examine the factor structure of the short-form of Center for Epidemiological Studies Depression Scale (CES-D-11) using confirmatory factor analysis (CFA). We extracted data from 670 people with physical disabilities (PWPD) from the Korea Welfare Panel. To investigate the model fit regarding factor structure, a one-factor model, four-factor model, and four-factor within bifactor model, as reported in previous studies, were examined using CFA, and goodness-of-fit indices were compared. As a result of the analysis, the four-factor model and the four-factor within bifactor model satisfied the criteria of correspondence with goodness-of-fit indices. Reliability of the four individual factors ranged from 0.722 to 0.834, indicating acceptable reliability. Validity and reliability of the four-factor within bifactor structure was confirmed through CFA and reliability analysis. In future studies using the CES-D-11 to measure depression in PWPD, comparison between four sub-factors and total scores might be possible.

Introduction

Research has indicated that people with physical disabilities or mental dysfunction experience depression more often than the general population (1). Due to the loss of physical functioning, people with physical disabilities (PWPD) can experience multi-faceted environmental effects like a failure to adequately cope with such changes, lower social participation, low self-esteem due to disability, and a lack of social support (2, 3). This is consistent with the view that physical disability represents a source of enduring social stress (4). Furthermore, chronic stress and loneliness are well-known risk factors for high levels of distress and depression (5).

Since PWPD have such a high risk of depression, their mental health issues must be considered in more depth. To better understand disability and depression, the ability to accurately measure depression for PWPD must take precedence. The Center for Epidemiologic Studies Depression Scale (CES-D), developed by Radloff (6), is a 20-item self-report scale that measures depression levels in the general population. It is one of the most widely used research tools worldwide (7, 8) and the reliability and validity of the CES-D has been established in several studies (9, 10).

As the measurement of depression is related to sociodemographic factors (11), studies have assessed the validity of the CES-D across different populations (8, 12, 13). The factor structure of the 20-item CES-D for Korean population was confirmed in various studies (14, 15). However, there is a lack of research investigating the psychometric properties of the CES-D for PWPD, a group with characteristics different from the general population and a high prevalence of depression. Despite the usefulness of the 20-item CES-D, it does not apply to respondents such as physically ill patients, the elderly, people with difficulty in reading or understanding the questions, and people having difficulty in answering a questionnaire with a larger number of questions. Recognizing that this could be a significant burden on respondents (16), interest in shortened versions of the CES-D has increased (1719). Previous studies confirming the usefulness of the CES-D for PWPD used a 20-item scale; the validity of the CES-D-11, however, has not been confirmed in this population. The correlation between the CES-D-11 and CES-D-20 was 0.95, and four subfactor structures were identified through factor analysis (20). The validity of CES-D-11 in Korean population was reported (21). A Korean study confirming the invariance of measurement between gender and age groups of CES-D-11 showed that it fit well with the 4-factor model (22). Hoe et al. (22) confirmed the following four factors: depressed, positive affect, somatic, and interpersonal relations.

The classic method for validating a scale is factor analysis; therefore, this study's purpose was to examine the validity of the CES-D-11 factor structure for PWPD. The specific research questions addressed were: (1) what is the factor structure of the CES-D-11 for PWPD? and (2) what is the reliability of the CES-D-11 for PWPD?

Methods

Participants

This study used data from the Korea Welfare Panel to verify the factor structure of the CES-D-11 for PWPD. Ethical approval was not applicable to this analysis. The following were inclusion criteria: first, participants were registered as PWPD under the Health and Welfare Act. The registration of individuals with disabilities requires the diagnosis of disability by a doctor who can register the type of disability according to their diagnosis. Therefore, participants in this study were limited to those who were diagnosed with a physical disability by a doctor. Second, participants who consented were included in the data investigation process. There were no specific exclusion criteria, however, if the participants included in the sample did not consent to respond to the scale, they were excluded and replaced by other participants by following the sampling procedure. Of the 670 respondents, 307 (45.8%) were male and 363 (54.2%) were female. Regarding age distribution, most respondents were above 60 (79.6%). The highest percentage of participants had an elementary school education level (n = 280, 41.8%). There were significant differences in depression levels across gender, age, and education level for PWPD. Respondents who were female, above 60 years old, illiterate, and had an elementary school education showed higher depression levels (Table 1). Configural invariance was used to calculate the fit index according to gender, age, and education level. Due to the small number of participants, configural invariance for ages below 41 could not be completed. As shown in Table 1, fit indices in each group showed an acceptable level, except for the RMSEA value in the 41–60 years group, illiteracy group, and graduate middle school group.

TABLE 1
www.frontiersin.org

Table 1. Score differences according to participants' general characteristics.

Measure

Depression was measured using the CES-D-11. Scores ≥ 16 are considered an indicator of clinically significant depressive symptoms (23). Items were scored on a 4-point Likert scale ranging from 0 (nearly or never) to 3 (most or all of the time), with higher scores being considered as indicators of clinical depression. Items included poor appetite, felt as good as others, felt depressed, felt everything was an effort, troubled sleep, felt lonely, unfriendly people, enjoyed life, felt sad, others dislike me, and could not get going.

Data Analysis

Confirmatory factor analysis (CFA) with maximum-likelihood estimation was conducted to determine the suitability of the CES-D-11 factor structure (24). The CES-D was originally developed using a four-factor structure; however, validity verification processes in subsequent studies suggested one-factor (25) and four-factor structures (26). Therefore, this study aimed to confirm the factor structure of CES-D-11 for PWPD by comparing one-factor and four-factor structures, as well as a bifactor structure, in order to determine the possibility of comparing total scores presented in previous studies. The unknown estimate uses a maximum likelihood method that assumes a multivariate normal distribution of measured variables (24). The goodness-of-fit index is usually used in several indices (27). In this study, χ2, relative sum index, and root mean square error were used as goodness-of-fit indices for the models. The χ2 test does not trust χ2 because researchers estimate the model from large data samples due to significant increases in the power of the sample; as the power increases, it is easy to reject models that explain its data well (28). CFI is a suggested value which improves the problem of the standard fit index and is considered a good model when the value is over 0.90 (29). Root Mean Square Error of Approximation (RMSEA) was used to examine residuals in the model and smaller values indicated better fit. Values below 0.08 are recommended as an acceptable level (30). Akaike information criterion (AIC) is useful for comparing two or more models. After factor analysis, the goodness of fit level of the CES-D-11 was examined. Data processing was performed using AMOS (ver. 24.0). After confirming factor structure, internal consistency of the CES-D-11 was examined using SPSS (ver. 24.0).

Results

CFA of the CES-D-11

Table 2 presents fit indices for each CES-D-11 model and measurement invariance according to gender. The first model posited that all items load on a single factor. In the second model, the items were hypothesized to load on four factors: depressed, positive affect, somatic, and interpersonal relations. Next, the bifactor model was examined. The fit indices supported the four-factor model for the CES-D-11 among PWPD. Although the four-factor model was identified as superior by the AIC value, the bifactor model also had strong goodness-of-fit indices. The results of the fitness test confirmed metric invariance, scalar invariance, uniqueness invariance, and factor variance/covariance invariance of the CES-D according to gender. Table 3 presents regression weights for the CES-D-11 four-factor model and four-factor within bifactor model. All paths showed significant coefficients at the 0.05 level.

TABLE 2
www.frontiersin.org

Table 2. Comparison of three competing models of the CES-D-11 and measurement invariance.

TABLE 3
www.frontiersin.org

Table 3. Regression weights of four-factor model.

Reliability and Correlation of the CES-D-11

As shown in Table 4, overall reliability of the scale was good. Cronbach's α coefficient, according to the four factors, was also good. Reliability coefficients were 0.834, 0.770, 0.791, and 0.722 for depressed, positive affect, somatic, and interpersonal relations, respectively. The correlation coefficients for four factors ranged from 0.371 (between positive affect and interpersonal relations) to 0.722 (between depressed and somatic) and all coefficients were statistically significant (p < 0.01).

TABLE 4
www.frontiersin.org

Table 4. Internal Consistency and correlation of the Four-Factor Model of the CES-D-11.

Discussion

The purpose of this study was to investigate the factor structure of the CES-D-11 and verify its validity for PWPD. Due to the potential severity of depression, the ability to detect and treat the condition early, particularly in populations which are at the most risk, is important to researchers and clinicians.

The original psychometric testing of the CES-D suggested a four-factor model (6). In a study on the factor structure of the CES-D-11, Kohout and Berkman (20) reported that it had the same factor structure as the original CES-D-20 (6). Gellis's study (31) surveyed elderly people receiving home health care and found that the CES-D-11 was similarly identified as in Radloff's study (6). However, in a study by Carpenter and Andrykowski (32) comparing the factor structure of the CES-D-11 in six different groups of women, only one group looked at the same factor structure as Radloff (6). There have been some reports of a one-factor structure among English- and Spanish-speaking participants (33) and patients with mental health disorders (34). The results of the present study showed a four-factor structure of the CES-D-11 for PWPD, which is consistent with the original study.

Additionally, the findings indicated that the bifactor CES-D-11 could be used for PWPD. The unidimensionality of the CES-D-11 was confirmed through CFA results for the bifactor model. Utilizing total scores measured using some scales is only possible if the unidimensionality of the scale meets the assumption (35). A CES-D-11 total score of 16 is used as a cutoff for potential depressive symptoms (23). Validated depression measures are required in rehabilitation programs in order to adequately reflect actual differences made by interventions for depression (36, 37) As an instrument's psychometric properties may vary depending on the population, if unidimensionality is not confirmed, a CES-D-11 cutoff score of 16 cannot be used for clinical screening. The results of the present study suggested that a four-factor model is suitable, and that the total CES-D-11 score can be used for PWPD.

Self-report measures should have internal consistency reliability over 0.70 (38); specifically, 0.70 is an acceptable level, 0.80 is good reliability, and above 0.90 is a maximum value for reliability. The results of this study suggested that the CES-D-11 has an adequate level of internal consistency in measuring depression in PWPD. Good reliability for the CES-D has been previously reported, such as an internal consistency of 0.95 in the Greek translation (10). Overall good reliability of 0.88 was reported in patients with systemic sclerosis, and reliability for the specific four factors of depressive affect, somatic/vegetative, interpersonal symptoms, and positive affect were 0.88, 0.80, 0.67, and 0.82, respectively (39). The results of the present study showed acceptable levels of reliability (above 0.70) for each of the four factors.

When using a measurement tool, verification of reliability and validity to determine whether it is measuring the intended variables, without errors, is a prerequisite. Proven measures of depression for PWPD are needed for screening and examining intervention effects. The choice of a measurement method best suited for an application depends on a number of factors: the nature of the study sample, burden on respondents, and management practices, as well as the scale's original intent and psychometric properties. Since psychometric characteristics of a measurement tool may differ according to population, it is necessary to systematically evaluate these characteristics before the widespread use of the tool within a specific population begins (40).

The strength of this study was using panel data with a systematic sampling method. However, there may still be limitations in the samples selected, such as the small size of the younger aged group. The structural elements of the questionnaire may vary according to the characteristics of the sample, such as language or culture. This can make it difficult to draw firm conclusions about whether the four factors are valid for Korean participants with physical disabilities.

In this study, we verified the suitability and reliability of the four-factor CES-D-11 model for PWPD. Considering the high rate of depressive symptoms for PWPD, it is necessary to establish effective support measures for screening, reducing, and preventing depression using a validated tool. The four-factor structured CES-D-11 may be useful in screening for depression in PWPD and verifying the effectiveness of interventions.

Data Availability Statement

Publicly available datasets were analyzed in this study. This data can be found at: https://www.koweps.re.kr:442/main.do.

Ethics Statement

Ethical approval was not provided for this study on human participants because Tishe study was based on a secondary analysis of previously collected and publicly available data and therefore an ethics approval was not required as per applicable institutional and national guidelines and regulations. Written informed consent from the participants' legal guardian/next of kin was not required to participate in this study in accordance with the national legislation and the institutional requirements.

Author Contributions

EY-P has made substantial contribution in interpretation and analysis of data, and drafting the manuscript.

Conflict of Interest

The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Acknowledgments

The author would like to thank Korea Welfare Panel Survey.

References

1. Kinne S, Patrick DL, Doyle DL. Prevalence of secondary conditions among people with disabilities. Am J Public Health. (2004) 94:443–5. doi: 10.2105/AJPH.94.3.443

PubMed Abstract | CrossRef Full Text | Google Scholar

2. Johanne DO, Danie O. Participation after stroke compared to normal aging. J Rehabil Med. (2005) 37:353–7. doi: 10.1080/16501970510037096

CrossRef Full Text | Google Scholar

3. Lewis BR, Turner RJ. Physical disability and depression: clarifying racial/ethnic contrasts. J Aging Health. (2010) 22:977–1000. doi: 10.1177/0898264309360573

PubMed Abstract | CrossRef Full Text | Google Scholar

4. Koenig HG, Pappas P, Holsinger T, Bachar JR. Assessing diagnostic approaches to depression in medically ill older adults: how reliably can mental health professionals make judgments about the cause of symptoms? J Am Geriatr Soc. (1995) 43:472–8. doi: 10.1111/j.1532-5415.1995.tb06091.x

PubMed Abstract | CrossRef Full Text | Google Scholar

5. Turner RJ, Wheaton B, Lloyd DA. The epidemiology of social stress. Am Sociol Rev. (1995) 60: 104–25. doi: 10.2307/2096348

CrossRef Full Text | Google Scholar

6. Radloff LS. The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Measur. (1977) 1:385–401. doi: 10.1177/014662167700100306

CrossRef Full Text | Google Scholar

7. Kim JH, Park EY. The factor structure of the center for epidemiologic studies depression scale in stroke patients. Top Stroke Rehabili. (2012) 19:54–62. doi: 10.1310/tsr1901-54

PubMed Abstract | CrossRef Full Text | Google Scholar

8. Campo-Arias A, Díaz-Martínez LA, Rueda-Jaimes GE, Cadena-Afanado LP, Hernández NL. Psychometric properties of the CES-D scale among Colombian adults from the general population. Revista Colombiana de Psiquiatría. (2007) 36:664–74. Available online at: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0034-74502007000400006&lng=en&nrm=iso

Google Scholar

9. Haringsma R, Engels GI, Beekman A, Spinhoven P. The criterion validity of the Center for Epidemiological Studies Depression Scale (CES-D) in a sample of self-referred elders with depressive symptomatology. Int J Geriatr Psychiatry. (2004) 19:558–63. doi: 10.1002/gps.1130

PubMed Abstract | CrossRef Full Text | Google Scholar

10. Fountoulakis K, Iacovides A, Kleanthous S, Samolis S, Kaprinis SG, Sitzoglou K, et al. Reliability, validity and psychometric properties of the Greek translation of the Center for Epidemiological Studies-Depression (CES-D) Scale. BMC Psychiatry. (2001) 1:3. doi: 10.1186/1471-244X-1-3

CrossRef Full Text | Google Scholar

11. Kazarian SS, Taher D. Validation of the Arabic Center for Epidemiological Studies Depression (CES-D) scale in a Lebanese community sample. Eur J Psychol Assess. (2010) 26:68–73. doi: 10.1027/1015-5759/a000010

CrossRef Full Text | Google Scholar

12. Devins GM, Orme CM, Costello CG, Binik YM, Frizzell B, Stam HJ, et al. Measuring depressive symptoms in illness populations: Psychometric properties of the Center for Epidemiologic Studies Depression (CES-D) scale. Psychol Health. (1988) 2:139–56. doi: 10.1080/08870448808400349

CrossRef Full Text | Google Scholar

13. Ros L, Latorre J, Aguilar M, Serrano J, Navarro B, Ricarte J. Factor structure and psychometric properties of the center for epidemiologic studies depression scale (CES-D) in older populations with and without cognitive impairment. Int J Aging Hum Dev. (2011) 72:83–110. doi: 10.2190/AG.72.2.a

PubMed Abstract | CrossRef Full Text | Google Scholar

14. Bae SW, Shin WS. The factor structure of the CES-D Scale (the Center for Epidemiologic Studies-Depression Scale): an application of confirmatory factor analysis. Health Soc Sci. (2005) 18: 165–90.

Google Scholar

15. Chon KK, Choi SC, Yang BC. Integrated Adaptation of CES-D in Korea. Kor J Health Psychol. (2001) 6:59–76.

Google Scholar

16. Carpenter J, Andrykowski M, Wilson J, Hal L, Kay RM, Sachs B, et al. Psychometrics for two short forms of the Center for Epidemiologic Studies-Depression Scale. Issues Ment Health Nurs. (1998) 19:481–94. doi: 10.1080/016128498248917

PubMed Abstract | CrossRef Full Text | Google Scholar

17. Andresen EM, Malmgren JA, Carter WB, Patrick DL. Screening for depression in well older adults: Evaluation of a short form of the CES-D. Am J Prev Med. (1994) 10:77–84. doi: 10.1016/S0749-3797(18)30622-6

PubMed Abstract | CrossRef Full Text | Google Scholar

18. Cole JC, Rabin AS, Smith TL, Kaufman AS. Development and validation of a Rasch-derived CES-D short form. Psychol Assess. (2004) 16:360–72. doi: 10.1037/1040-3590.16.4.360

PubMed Abstract | CrossRef Full Text | Google Scholar

19. Grzywacz JG, Hovey JD, Seligman LD, Arcury TA, Quandt SA. Evaluating short-form versions of the CES-D for measuring depressive symptoms among immigrants from Mexico. Hisp J Behav Sci. (2006) 28:404–24. doi: 10.1177/0739986306290645

PubMed Abstract | CrossRef Full Text | Google Scholar

20. Kohout FJ, Berkman LF, Evans DA, Cornoni-Huntley J. Two shorter forms of the CES-D depression symptoms index. J Aging Health. (1993) 5:179–93. doi: 10.1177/089826439300500202

PubMed Abstract | CrossRef Full Text | Google Scholar

21. Park EY, Kim JH. Unidimensionality and measurement invariance of the 11-item Korean CES-D Scale among examining parents of individuals with cerebral palsy. J Child Fam Stud. (2020) 29: 895–903. doi: 10.1007/s10826-019-01630-2

CrossRef Full Text | Google Scholar

22. Hoe M, Park B, Bae S. Testing measurement invariance of the 11-item Korean version CES-D scale. Ment Health Soc Work. (2015) 43:313–39.

Google Scholar

23. Lehmann V, Makine C, Karşidag Ç, Kadioglu P, Karşida K, Pouwer F. Validation of the Turkish version of the Centre for Epidemiologic Studies Depression Scale (CES-D) in patients with type 2 diabetes mellitus. BMC Med Res Methodol. (2011) 11:109. doi: 10.1186/1471-2288-11-109

PubMed Abstract | CrossRef Full Text | Google Scholar

24. Kline P. An Easy Guide to Factor Analysis. New York, NY: Routledge (2014). doi: 10.4324/9781315788135

CrossRef Full Text | Google Scholar

25. Edman JL, Danko GP, Andrad N, McArdle J, Foste J, Glipa J. Factor structure of the CES-D (Center for Epidemiologic Studies Depression scale) among Filipino-American adolescents. Soc Psychiatry Psychiatr Epidemiol. (1999) 34:211–5. doi: 10.1007/s001270050135

PubMed Abstract | CrossRef Full Text | Google Scholar

26. McCauley SR, Pedroza C, Brown SA, Boake C, Levin HS, Goodman HS, et al. Confirmatory factor structure of the Center for Epidemiologic Studies-Depression scale (CES-D) in mild-to-moderate traumatic brain injury. Brain Inj. (2006) 20:519–27. doi: 10.1080/02699050600676651

PubMed Abstract | CrossRef Full Text | Google Scholar

27. Finch JF Wes SGThe investigation of personality structure: statistical models. J Res Pers. (1997) 31:439–85. doi: 10.1006/jrpe.1997.2194

CrossRef Full Text | Google Scholar

28. Hoyle RH. Structural equation modeling: Concepts, issues, and applications. London: Sage (1995).

Google Scholar

29. Hu L, Bentler PM. Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives. Struc Equ Model: Multidiscipl J. (1999) 6:1–55. doi: 10.1080/10705519909540118

CrossRef Full Text | Google Scholar

30. O'Rourke N, Hatcher LA. Step-by-Step Approach to Using SAS for Factor Analysis and Structural Equation Modeling. Cary, NC: SAS Institute (2013).

Google Scholar

31. Gellis ZD. Assessment of a brief CES-D measure for depression in homebound medically ill older adults. J Gerontol Soc Work. (2010) 53:289–303. doi: 10.1080/01634371003741417

PubMed Abstract | CrossRef Full Text | Google Scholar

32. Carpenter JS, Andrykowski MA. Psychometric evaluation of the Pittsburgh sleep quality index. J Psychosom Res. (1998) 45:5–13. doi: 10.1016/S0022-3999(97)00298-5

PubMed Abstract | CrossRef Full Text | Google Scholar

33. González P, Nuñez A, Merz E, Brintz C, Weitzman O, Navas EL, et al. Measurement properties of the Center for Epidemiologic Studies Depression Scale (CES-D 10): findings from HCHS/SOL. Psychol Assess. (2017) 29:372–81. doi: 10.1037/pas0000330

PubMed Abstract | CrossRef Full Text | Google Scholar

34. Björgvinsson T, Kertz SJ, Bigda-Peyton JS, McCoy KL, Aderka IM. Psychometric properties of the CES-D-10 in a psychiatric sample. Assess. (2013) 20:429–36. doi: 10.1177/1073191113481998

PubMed Abstract | CrossRef Full Text | Google Scholar

35. Slocum-Gori SL, Zumbo BD. Assessing the unidimensionality of psychological scales: Using multiple criteria from factor analysis. Soc Indic Res. (2011) 102:443–61. doi: 10.1007/s11205-010-9682-8

CrossRef Full Text | Google Scholar

36. Ferro MA, Speechley KN. Factor structure and longitudinal invariance of the Center for Epidemiological Studies Depression Scale (CES-D) in adult women: application in a population-based sample of mothers of children with epilepsy. Arch Womens Ment Health. (2013) 16:159–66. doi: 10.1007/s00737-013-0331-5

PubMed Abstract | CrossRef Full Text | Google Scholar

37. Mohebbi M, Nguyen V, McNeil JJ, Woods RL, Nelson MR, Shah RC, et al. Psychometric properties of a short form of the Center for Epidemiologic Studies Depression (CES-D-10) scale for screening depressive symptoms in healthy community dwelling older adults. Gen Hosp Psychiatry. (2018) 51:118–25. doi: 10.1016/j.genhosppsych.2017.08.002

PubMed Abstract | CrossRef Full Text | Google Scholar

38. Nunnally JC, Bernstein IH. The theory of measurement error. Psychometr Theory. (1994)3:209–47.

Google Scholar

39. Thombs BD, Hudson M, Schieir O, Taillefer SS, Baron M. Canadian Scleroderma Research Group. Reliability and validity of the center for epidemiologic studies depression scale in patients with systemic sclerosis. Arthritis Rheum. (2008) 59:438–3. doi: 10.1002/art.23329

CrossRef Full Text | Google Scholar

40. Wren TA, Sheng M, Bowen RE, Scaduto AA, Kay RM, Otsuka NY, et al. Concurrent and discriminant validity of Spanish language instruments for measuring functional health status. J Pediatr Orthop. (2008) 28:199–212. doi: 10.1097/BPO.0b013e318165216d

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: factor structure, Center for Epidemiological Studies Depression scale, people with physical disabilities, validity, reliability

Citation: Park E-Y (2021) Factor Structure of the Short-Form of Center for Epidemiological Studies Depression Scale for People With Physical Disabilities. Front. Psychiatry 12:536499. doi: 10.3389/fpsyt.2021.536499

Received: 20 February 2020; Accepted: 23 March 2021;
Published: 14 April 2021.

Edited by:

Jutta Lindert, University of Applied Sciences Emden Leer, Germany

Reviewed by:

Rocio de la Vega, University of Malaga, Spain
John L. Perry, Mary Immaculate College, Ireland

Copyright © 2021 Park. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Eun-Young Park, eunyoung@jj.ac.kr

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.