BRIEF RESEARCH REPORT article
Front. Psychiatry
Sec. Autism
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1452940
MTHFR C677T is not associated with autism spectrum disorder in a Mexican cohort
Provisionally accepted
- National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
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Using genetic approaches to study autism spectrum disorder (ASD) is essential to understanding the etiology of the condition. The C677T variant has emerged as a risk factor, and here we present the first association study of this variant in a Mexican population with ASD. Our objective was to assess the variant MTHFR C677T (rs1801133) in a group of Mexican patients with ASD through a casecontrol association analysis. We found no significant association of MTHFR C677T and ASD, with no rate differences between cases and controls (C vs T: odds ratio = 0.9698, 95% confidence interval = 0.7773-1.21, P = 0.7858). Results of this and other studies evaluating the link between ASD and this variant have been controversial. Our findings suggest that other ancestry-related factors may play a role.
Keywords: MTHFR, C677T, Genetic variant, ASD, Mexican population
Received: 21 Jun 2024; Accepted: 31 Mar 2025.
Copyright: © 2025 Castro, Morales Marín, Nicolini and Cid Soto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xochitl H Castro, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
Humberto Nicolini, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico
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