SYSTEMATIC REVIEW article
Front. Psychiatry
Sec. Mood Disorders
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1498773
Exploring the bidirectional relationship between depressive disorder and dyslipidemia: A systematic review and meta-analysis
Provisionally accepted
- 1China Academy of Chinese Medical Sciences, Beijing, China
- 2Shaanxi Academy of Traditional Chinese Medicine, Xi 'an, China
- 3Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China
- 4Department of Rehabilitation, Xi'an TCM Hospital of Encephalopathy, Xi 'an, China
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Objective: To explore the bidirectional association between dyslipidemia and depression, and the potential predictive role of lipid level changes for depression onset. Methods: A systematic search of the Cochrane Library, Web of Science, Embase, and PubMed databases was conducted to identify cohort studies on blood lipids and 5-hydroxytryptamine (5-HT) parameters related to depression, from database inception to May 2024. Data were analyzed using Stata 14.0 software. Results: Seven studies were included in the analysis. Serum high-density lipoprotein (HDL) and triglyceride levels are significantly associated with an increased risk of depression (OR = 1.28, 95% CI: 1.07 - 1.53; OR = 1.41, 95% CI: 1.20 - 1.66, P < 0.05). However, depressive symptoms do significantly affect serum HDL, LDL, triglyceride, or total cholesterol levels (ORs = 0.88, 1.05, 1.05, 1.11; 95% CIs: 0.58 - 1.35, 0.88 - 1.24, 0.91 - 1.21, 0.9 - 1.32, P > 0.05). Conclusion: Based on the present findings, changes in serum HDL and triglyceride levels are significantly linked to depression incidence. Monitoring these two lipid parameters may aid in early identification of at-risk individuals and enhance the prognosis and quality of life for depressed patients through timely interventions.
Keywords: Depressive Disorder, Bidirectional relationship, serum 5-HT, Dyslipidemia, A systematic, Meta-analysis
Received: 20 Sep 2024; Accepted: 13 Oct 2025.
Copyright: © 2025 Jin, Kang, Lu, Yang, Zhou, Gao, Liu and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: XXiaxia Jin, 1992631677@qq.com
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