ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Addictive Disorders
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1548585
This article is part of the Research TopicTreatment and Management of Stimulant Use Disorder and Co-Occurring DisordersView all articles
COT-TT VACCINE ATTENUATES INDUCTION AND EXPRESSION OF COCAINE-INDUCED BEHAVIORAL SENSITIZATION IN RATS: A DOSE-RESPONSE STUDY
Provisionally accepted
Susana Barnbosa-Mendes
Alberto Salazar-Juarez*- National Institute of Psychiatry Ramon de la Fuente Muñiz (INPRFM), Mexico City, Mexico
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Active vaccination is an effective therapeutic strategy, capable of decreasing the reinforcing and psychomotor effects of cocaine. Clinical studies have shown that cocaine vaccines show an irregular generation of antibody titers, which are rapidly reduced in the absence of reimmunization. The COC-TT vaccine has demonstrated, in rodents, the production of high levels of anti-cocaine antibodies, capable of reducing the cocainereinforcing effects, but the adequate dose to obtain the highest antibody titers has not yet been determined, as well as the kinetics of the decay of titers and the capacity to decrease the locomotor activity induced by different doses of cocaine during the phase of decay of titers, induction and expression of locomotor sensitization. The objective of this study was to determine the optimal dose of the COC-TT vaccine, the decay kinetics of anti-cocaine titers, and the efficacy of the antibodies to decrease the locomotor activity induced by different doses of cocaine.Male Wistar rats were immunized with the COC-TT. A solid-phase antibody-capture ELISA was used to monitor antibody titer responses after each booster dose in vaccinated animals. The study used cocaine-induced locomotor activity testing to evaluate the cocaine-psychomotor effects.The COC-TT vaccine could generate high levels of anti-cocaine antibodies. These showed a gradual, dose-dependent decay kinetics of the COC-TT vaccine and a rapid recovery in antibody levels after re-immunization. Furthermore, the antibodies attenuated cocaineinduced locomotor activity during the induction and expression of locomotor sensitization.These findings suggest that the COC-TT vaccine generates a robust immunogenic response capable of reducing the reinforcing effects of cocaine, which supports its possible future use in clinical trials in patients with CUD.
Keywords: Active vaccination, Cocaine, Antibodies, COC-TT vaccine, Cocaine selfadministration, cocaine place preference Cocaine-10mg Cocaine-20mg Cocaine-40mg Days
Received: 19 Dec 2024; Accepted: 19 May 2025.
Copyright: © 2025 Barnbosa-Mendes and Salazar-Juarez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Alberto Salazar-Juarez, National Institute of Psychiatry Ramon de la Fuente Muñiz (INPRFM), Mexico City, Mexico
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.