Depression Subtypes, Suicidality, and Healthcare Costs in Older Adults: Results from a Naturalistic Study

Ismael Conejero^1*Alejandro Albán Porras-Segovia²Lucía Albarracín-García³Maria Luisa Barrigón⁴Jorge Lopez-Castroman⁵Philippe Courtet⁶Enrique Baca-Garcia³MEmind Group⁷

• ¹Centre Hospitalier Universitaire de Nîmes, Nîmes, France
• ²Hospital Universitario Rey Juan Carlos, Madrid, Madrid, Spain
• ³Instituto de Investigación Sanitaria Fundación Jiménez Díaz; Universidad Autónoma de Madrid; Department of Psychiatry, Hospital Universitario Fundación Jiménez Díaz, Madrid, Asturias, Spain
• ⁴Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, ISCIII, School of Medicine, Universidad Complutense, Madrid, Spain
• ⁵Department of Psychiatry, Radiology, Public Health, Nursing and Medicine; University of Santiago de Compostela, Santiago de Compostela, Spain
• ⁶Department of Emergency Psychiatry and Acute Care, Centre Hospitalier Universitaire Montpellier, University of Montpellier, Montpellier, France
• ⁷MEmind Group, Madrid, Spain

The burden of depression is increasing worldwide, particularly in older populations. While the impact of depressive disorders on suicide in later life has been clearly identified, less is known about the role of their subtypes and their costs in the elderly.We aimed to describe the sociodemographic and clinical characteristics associated with the depression subtypes and suicidality, and their related healthcare costs in older adults receiving mental healthcare.The study was carried out across four psychiatry departments in Madrid, Spain.Adults aged over 60 years were included if they attended the psychiatric inpatient or outpatient services and were diagnosed with Major Depressive Disorder (MDD), recurrent depressive disorder, bipolar depression, or dysthymia. Sociodemographic data and diagnoses according to the International Classification of Diseases, 10 th edition were obtained from electronic health records. Lifetime suicidal history, suicidal ideation and suicide attempts in the previous month were identified using the Columbia Suicide Severity Rating Scale (CSSRS). Mean healthcare costs were calculated over one year.Results: N=2868 patients were included in the analysis. Of these, 550 were assessed with the CSSR. The mean age of the sample was 70.05 years and 75.9% of the patients were women (N=2177). Of the patients assessed with the CSSRS (N=550), 83.2% (N=458) reported suicidal ideation, and 7.3% (N=40) had attempted suicide in the previous month. Psychiatric healthcare costs over the follow-up differed between the depression subtypes (Eta-squared 0.003 CI [0.000 -0.008]; p<0.001). They were significantly higher in patients diagnosed with bipolar depression, than in those diagnosed with dysthymia (p=0.026), but did not differ from those bearing MDD (p= 0.775) or recurrent depressive disorder (p= 0.129).Recent suicide attempters had a more frequent lifetime history of suicide attempt (OR= 8.434).Suicide attempts were more frequent in individuals aged 71-80 years (OR= 3.433) or over 80 years (OR= 3.322), and in patients with recurrent depressive disorders (OR= 3.529).Psychiatric healthcare costs differed between depression subtypes, with a small effect. Furthermore, older age, a diagnosis of recurrent depression, and a history of suicide attempts increased the risk of suicide. Health policies should target these populations to improve mental health outcomes in the older adults.