ORIGINAL RESEARCH article

Front. Psychiatry

Sec. Mood Disorders

Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1564225

Effects of Positive Psychological Interventions on Quality of Life in Patients with First-Episode Depression

Provisionally accepted
Lizhao  LvLizhao LvKeyan  Han #Keyan Han #Limin  MengLimin MengJincheng  WangJincheng WangHui  YinHui YinKenan  RenKenan RenZhihua  LiuZhihua Liu*
  • The First hospital of Hebei Medical University, Shijiazhuang, China

The final, formatted version of the article will be published soon.

Objective: This study aims to investigate the effects of positive psychological interventions (PPIs) on improving the quality of life in first-episode depression patients.Methods: A total of 200 first-episode depression patients were randomly assigned to a control group (n=100, conventional nursing) or a study group (n=100, conventional care plus four weekly 60–80-minute PPI sessions over one month). Depression severity (Hamilton Depression Rating Scale, HAMD), psychological resilience (Connor-Davidson Resilience Scale, CD-RISC), self-acceptance (Self Acceptance Questionnaire, SAQ), and quality of life (SF-36) were assessed pre-intervention and 3 months post-intervention.Results: Baseline measures showed no significant intergroup differences (P>0.05). At 3 months, the study group exhibited greater HAMD reduction (Δ=11.16 vs. Δ=9.09 in controls; mean post-intervention: 17.03±3.45 vs. 19.23±3.21, p<0.001), higher CD-RISC improvement (Δ=36.27 vs. Δ=29.54; 80.09±7.86 vs. 73.92±7.36, p<0.001), and increased SAQ total scores (Δ=18.17 vs. Δ=12.25; 43.47±9.21 vs. 37.84±8.24, p<0.001). SF-36 total scores improved by 52.0% in the study group (540.41±32.66 vs. 276.41±27.99) compared to 42.5% in controls (487.85±31.89 vs. 279.48±26.39, p<0.001).Conclusion: PPIs delivered over four weeks significantly enhance quality of life and psychological outcomes in first-episode depression, supporting clinical adoption.

Keywords: Positive psychological intervention, Improvement, First-episode depression, Quality of Life, Depression status, psychological resilience scores, self-acceptance

Received: 21 Jan 2025; Accepted: 20 Jun 2025.

Copyright: © 2025 Lv, Han #, Meng, Wang, Yin, Ren and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Zhihua Liu, The First hospital of Hebei Medical University, Shijiazhuang, China

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