PERSPECTIVE article

Front. Psychiatry

Sec. Psychopharmacology

Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1568777

Optimizing the Diagnosis and Treatment of Depression in Primary Care: The Emerging Role of Vortioxetine Treatment

Provisionally accepted
José Ángel AlcaláJosé Ángel Alcalá1*Verónica Olmo DoradoVerónica Olmo Dorado2Guadalupe del Pilar Arilla HerreraGuadalupe del Pilar Arilla Herrera3Silvia López ChamónSilvia López Chamón4Vicente Gasull MolineraVicente Gasull Molinera5
  • 1Reina Sofia University Hospital, Cordoba, Spain
  • 2Centro de Salud Torreblanca, Seville, Spain
  • 3Centro de Salud Alagón, Zaragoza, Spain
  • 4Centro de Salud Huerta de los Frailes, Madrid, Spain
  • 5Clínica Eliana, Torrent, Valencia, Spain

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The management of patients with major depressive disorder (MDD) in primary care (PC) represents a significant challenge and a great opportunity for early and effective intervention. Primary care physicians, as first-line physicians, play a key role in the identification, diagnosis and initial treatment of depression, often being the first and sometimes the only point of contact for these patients with the healthcare system. In this context, the search for effective and well-tolerated therapeutic strategies is constant, and vortioxetine represents a good pharmacological option within the therapeutic armamentarium available to the PC physician. This article explores best practices in the management of MDD from the PC perspective, addressing the specific challenges faced by these professionals and examining the potential role of vortioxetine in the treatment of different patient profiles.

Keywords: Major Depressive Disorder, Primary Care, Vortioxetine, Antidepressants, cognitive deficits, emotional blunting

Received: 04 Feb 2025; Accepted: 15 May 2025.

Copyright: © 2025 Alcalá, Olmo Dorado, Arilla Herrera, López Chamón and Gasull Molinera. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: José Ángel Alcalá, Reina Sofia University Hospital, Cordoba, 14004, Spain

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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