ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Adolescent and Young Adult Psychiatry
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1582971
This article is part of the Research TopicAdolescent Emotional Disorders and Suicide Self-Harm Crisis InterventionView all 15 articles
Study of Pain Perception under Negative Emotions and Its Large-scale Brain Network Dynamics in Adolescents with Non-suicidal self-injury
Provisionally accepted
Yang Zhou
Dong-Dong Zhou
Zheng-Yong ZhangHui-Yu JiaFang Chen
Liuyi RanXiao-Rong ChenLi-Yang WanYi-Jia WangWo Wang*- University-Town Hospital of Chongqing Medical University, Chongqing, China
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Previous studies have indicated that negative emotions are one of the primary causes of Non-suicidal self-injury (NSSI) behaviour. This study focuses on examining the characteristics of large-scale brain network dynamics associated with pain perception in NSSI adolescents following experiences of negative emotions.A total of 44 adolescents with Major Depressive Disorder (MDD) and NSSI (MDD+NSSI group), 21 MDD adolescents without NSSI (MDD group), and 25 healthy controls (HC group) were recruited. Two emotional conditions (neutral and negative) were established, followed by the simulation of pain conditions using ice water stimulation, while electroencephalogram (EEG) signals were recorded using a 64-channel EEG system. Statistical analysis was conducted using mixed-design repeated measures analysis of variance, with multiple comparisons corrected using the Bonferroni method.In the MDD+NSSI group, after sadness induction, the duration, time coverage of microstate A, and the transition rate from microstate B→A during the Cold Pressor Test (CPT) were significantly higher compared to neutral emotion induction. Conversely, the occurrence frequency of microstate B decreased markedly. Under neutral emotion induction, the MDD group exhibited higher occurrence frequency of microstate A and transition rate from microstate D→A than the HC group. In contrast, the occurrence frequency, coverage of microstate B, and transition probabilities from microstates C/D→B were significantly lower in the MDD group than in the HC group.Our findings suggest that adolescents with MDD who exhibit NSSI behaviour display abnormalities in large-scale brain network dynamics associated with pain perception following experiences of negative emotions, indicating that EEG microstates may serve as neurobiological markers for abnormal pain perception in NSSI adolescents.
Keywords: Non-suicidal self-injury(NSSI), Adolescent, Cold Pressor Test(CPT), EEG microstates, large-scale brain network dynamics
Received: 25 Feb 2025; Accepted: 21 May 2025.
Copyright: © 2025 Zhou, Zhou, Zhang, Jia, Chen, Ran, Chen, Wan, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wo Wang, University-Town Hospital of Chongqing Medical University, Chongqing, 401331, China
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