ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Psychopathology
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1585083
This article is part of the Research TopicThe Heterogeneity of Psychiatric Symptoms and DisordersView all 19 articles
Prevalence and Correlates of depression and depression-anxiety in patients received gastroscopy
Provisionally accepted
- Department of Psychiatry, Second People's Hospital of Hunan Province, Changsha, Hunan Province, China
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Objective: There are increasing numbers of patients suffering from gastrointestinal disorders who are at primary risk for depression. These patients often have no awareness of their depression and therefore choose to see their gastroenterologists. Normally gastroenterologists advise the patients to undergo gastroscopy to investigate their possible digestive disorders while overlooking their depression. This study investigated the prevalence of the comorbidities between depression, depression-anxiety and organic diseases of upper gastrointestinal tract (UGI) among patients receiving gastroscopy in a large general hospital in China.Methods: A total of 707 patients who agreed to recommendation for gastroscopy were investigated using the nine-item Patient Health Questionnaire (PHQ-9). The patients of PHQ-9 scores ≥10 were further interviewed using the Hamilton depressive scale (HAMD) ， Hamilton 2 anxiety scale (HAMA) and DSM-IV to confirm the diagnosis.Results: Altogether, 412 patients were found to suffer from organic diseases of UGI based on the gastroscopy results. Of these, 51 patients and 34 were diagnosed with major depression and depression-anxiety respectively. The detection rate of depression by gastroenterologists was 3.92% while no depression-anxiety was diagnosed. Multiple logistic regression showed the course of disease, number of gastroscopies and age were significantly associated with major depression while educational level, income, age, and number of gastroscopies were significantly associated with depression-anxiety.The comorbidities rates between depression, depression-anxiety and organic diseases of UGI are higher than the general population in China. However, the detection rates of the comorbidities by gastroenterologists are low.
Keywords: Depression, Depression-anxiety, Prevalence, Organic Gastrointestinal diseases, Upper gastrointestinal
Received: 28 Feb 2025; Accepted: 06 Aug 2025.
Copyright: © 2025 Liu, Hua and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chang Liu, Department of Psychiatry, Second People's Hospital of Hunan Province, Changsha, 410127, Hunan Province, China
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