REVIEW article
Front. Psychiatry
Sec. Schizophrenia
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1590886
MRI-Based Insights into Brain Structural and Functional Alterations in Schizophrenia Treated with Risperidone
Provisionally accepted
- Affiliated Hospital of North Sichuan Medical College, Nanchong, China
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AbstractBackground: Schizophrenia (SZ) is a severe psychiatric disorder, with antipsychotics serving as the primary treatment. Among them, risperidone plays a crucial role in alleviating both positive and negative symptoms while also enhancing cognitive function. Advances in magnetic resonance imaging (MRI) technology have provided an effective means of investigating the effects of risperidone on the brain, particularly in terms of neural pathways, therapeutic efficacy, and predictive outcomes. This review offers a summary of current findings on the impact of risperidone treatment on gray matter, white matter, and functional brain activity and connectivity in SZ patients, including its neural mechanisms, therapeutic benefits, and potential side effects. Methods: Literatures on the use of risperidone for treating schizophrenia were searched in PubMed, Embase and Web of Science analyzing and summarizing the alterations in brain structure and function associated with risperidone. Results: Through the analysis and summary, it was found that risperidone treatment in SZ patients can have a marked effect on different structural and functional regions including the prefrontal lobe, temporal lobe, cingulate gyrus, corona radiata, basal ganglia, and corpus callosum. Conclusion: Most research has focused on short-term effects, with limited longitudinal data to assess long-term efficacy and side effects，more researches could be added in the future. In addition, more potential methods such as DKI , DSI and brain covariance network have the opportunity to be used in the study of brain structure and function in the treatment of schizophrenia with risperidone in the future
Keywords: Magnetic Resonance Imaging, gray matter, white matter, fMRI, Schizophrenia, risperidone cognitive function
Received: 10 Mar 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Li, Chen, Peng, Li, Yu, Liao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Nian Liu, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.