ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Mood Disorders
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1597196
Longitudinal associations between psychological factors, community integration, and suicide risks among patients with treatment-resistant depression in Vietnam
Provisionally accepted
Pham Thi Thu Huong1*
Chia-Yi Jenny Wu2,3,4,5
Lee Ming Been6
Nguyen Van Tuan1,7Pham Thi Thu Hien7Nguyen Thi Lan Anh1Nguyen Thi Son1,8Nguyen Thi Thu Hien7- 1Hanoi Medical University, Hanoi, Vietnam
- 2College of Medicine, National Taiwan University, Taipei, Taiwan
- 3National Taiwan University Hospital, Taipei, Taiwan
- 4Taiwan Association Against Depression, Taipei, Taiwan
- 5Taiwanese Society of Suicidology & Taiwan Suicide Prevention Center, Taipei, Taiwan
- 6Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
- 7Bach Mai hospital, Hanoi, Vietnam
- 8Hanoi Medical University Hospital, Hanoi, Vietnam
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Objective: To examine longitudinal associations of psychological distress, community integration, suicide ideation, and attempts within 3-month post-discharge period among patients with treatment-resistant depression (TRD).Methods: Prospective study design with a 3-month followed-up from the hospital admission through to the participants' community reintegration. All the 53 patients with TRD were interviewed one week after admission (T0) plus 1-month (T1) and three months (T2) after discharge with a structured questionnaire from October 2021 to September 2022. Descriptive and correlational analysis of the trend and associates of TRD suicide risks were performed.The results revealed that suicide ideation and attempt rates reduced after inpatient treatment, but increased altogether from T1 to T2 in the community. Nearly half of the participants (46%) reported recent suicide ideation, and 13.46% attempted suicide at T2. Perceiving poor quality of life and a low level of community integration performance were associated modestly with suicide ideation, with 1.02-and 1.10-times higher risk, respectively. On the other hand, a high level of psychological distress increased the hazard of suicide attempts by 1.13-fold.Conclusions: Our findings suggest future suicide prevention strategies and the importance of regular assessment of inpatients and outpatients for psychological distress to identify and engage high-risk individuals.
Keywords: treatment-resistant depression, longitudinal study, Community Integration, suicide ideation, suicide attempt, psychological fluctuation
Received: 20 Mar 2025; Accepted: 02 Jul 2025.
Copyright: © 2025 Huong, Wu, Been, Van Tuan, Hien, Lan Anh, Son and Hien. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Pham Thi Thu Huong, Hanoi Medical University, Hanoi, Vietnam
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