ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Anxiety and Stress Disorders
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1598767
Influence of comorbid anxiety and depression disorder on cognition in older adults with epilepsy
Provisionally accepted
- Wuhan Mental Health Center, Wuhan, China
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Objective: This study aims to investigate the association of comorbid depression and anxiety with cognitive function in older adults with epilepsy.: A cross-sectional analysis was conducted on 406 older adults (≥65 years) diagnosed with epilepsy between January 2019 and December 2020. Depressive and anxious symptoms were measured using the Hospital Anxiety and Depression Scale (HADS), while cognitive impairment was assessed with the Montreal Cognitive Assessment Test (MoCA). Multivariate linear regression models were used to examine associations between cognitive impairment and anxiety/depression symptoms, adjusting for potential confounders.Results: Of the 406 adults, 218 (53.7%) showed cognitive impairment. Adults with depression (70.2% vs. 51.0%, P<0.01) or anxiety (66.7% vs. 48.8%, P<0.01) had a significantly higher prevalence of cognitive impairment compared to those without these conditions. Multivariate linear regression analysis (Table 2) revealed significant associations between cognitive impairment and depression (β=-1.77, 95% CI: -2.67, -0.87; P<0.01) and anxiety (β=-2.18, 95% CI: -2.95, -1.42; P<0.01).Anxiety and depression are significantly associated with cognitive impairment in older adults with epilepsy. Early screening and management of these psychiatric conditions are essential to reduce cognitive decline and enhance patient outcomes.
Keywords: Anxiety, Depression, Cognition, Epilepsy, older
Received: 24 Mar 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Qiu, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hui Qiu, Wuhan Mental Health Center, Wuhan, China
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