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ORIGINAL RESEARCH article

Front. Psychiatry

Sec. Sleep Disorders

Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1600675

Effects of paroxetine combined with sulpiride on sleep status and quality of life in patients with depressive episodes

Provisionally accepted
Di  ZhaoDi Zhao1*Chunyu  LiuChunyu Liu2
  • 1The First Harbin Psychiatric Hospital, Harbin, China
  • 2Internal medicine,Wanjia Compulsory Isolation and Drug Rehabilitation Hospital in Harbin,Harbin City, Heilongjiang Province,150000,China, Harbin, China

The final, formatted version of the article will be published soon.

Objective: Assess the clinical efficacy of paroxetine and sulpiride IV drip in treating depression and its impact on sleep and quality of life. Methods: Retrospective analysis of 80 depression patients, divided into a study group treated with paroxetine and sulpiride IV drip, and a control group treated with paroxetine alone, over 8 weeks. HAMD and SF-36 assessed depression and quality of life; TESS evaluated adverse reactions. Results: HAMD scores decreased in both groups, with the study group showing better depression status at 1, 2, and 4 weeks (P<0.05) and higher effective rates (P<0.05). The study group had faster symptom relief. SF-36 scores in role physical, general health, vitality, and role emotional were higher in the study group (P<0.05). TESS scores showed no significant difference between groups (P>0.05), with mild adverse reactions. Conclusion: Paroxetine with sulpiride IV drip offers rapid relief and high safety in depression treatment, improving sleep and quality of life.

Keywords: Paroxetine, Sulpiride, Depressive Disorder, Sleep status, Quality of Life

Received: 26 Mar 2025; Accepted: 29 Aug 2025.

Copyright: © 2025 Zhao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Di Zhao, The First Harbin Psychiatric Hospital, Harbin, China

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