CASE REPORT article
Front. Psychiatry
Sec. ADHD
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1604523
The Gender-Sensitive Spectrum of Neurodevelopmental Disorders: A Case Report on a ZMYM3 Variant in a 19-Year-Old Female
Provisionally accepted
Alberto Cordella1*
Silvia Beatrice Maitz2
Daniela Distefano3Marianna Lissi4
Lucia Morellini4
Leonardo Sacco1- 1Ente Ospedaliero Cantonale, Regional Hospital of Lugano, Department of Neurology, Neurocenter of Southern Switzerland, 6900, Lugano, Switzerland
- 2Medical Genetics Service, Oncology Department of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland
- 3Department of Neuroradiology, Neurocenter of Southern Switzerland, Lugano, Switzerland
- 4Neuropsychological and Speech Therapy Unit, Neurocenter of Southern Switzerland, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
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Background: Neurodevelopmental disorders (NDDs) such as Intellectual Disability, Autism Spectrum Disorder (ASD), and Attention-Deficit/Hyperactivity Disorder (ADHD) impact cognitive, behavioral, and social functions. The Zinc finger MYM-type protein 3, located on the X-chromosome, has been implicated in neurodevelopment, but its effects in females remain poorly understood due to limited research.We report a 19-year-old female with a de novo heterozygous variant in ZMYM3 (NM_201599.3:c.1927C>G, p.( His643Asp)), presenting with ADHD symptoms, poor motor coordination, and mild cognitive impairments. Although her language development was normal, she exhibited motor delays, learning and social difficulties, leading to anxiety and academic struggles.Neuropsychological assessment revealed an IQ of 85, with significant deficits in working memory and visuospatial reasoning but relative strengths in verbal comprehension. Brain MRI showed an incomplete left-sided hippocampal inversion. Genetic analysis confirmed the presence of the ZMYM3.Discussion and conclusion: This case contributes to the limited literature on ZMYM3-related NDDs in females, highlighting potential variability in phenotypic expression due to X-inactivation and penetrance effects. The patient's symptoms emphasize how ADHD and other neurodevelopmental traits may manifest differently in females, often with more subtle and internalized features. Our findings underscore the importance of sex-specific research on ZMYM3-associated disorders and the need for comprehensive genetic and neuropsychological assessments to guide diagnosis and intervention in affected individuals.
Keywords: Neurodevelopmental disorders, ZMYM3 gene, ADHD, gender differences, Genetic Testing, neuropsychological assessment, case report
Received: 02 Apr 2025; Accepted: 31 Jul 2025.
Copyright: © 2025 Cordella, Maitz, Distefano, Lissi, Morellini and Sacco. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Alberto Cordella, Ente Ospedaliero Cantonale, Regional Hospital of Lugano, Department of Neurology, Neurocenter of Southern Switzerland, 6900, Lugano, Switzerland
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