ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Public Mental Health
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1607551
This article is part of the Research TopicMental Health Challenges in Long-term Pharmacotherapy for Patients with Chronic DiseasesView all 11 articles
Latent Class Analysis of Inflammation and Drug-Induced Liver Injury Phenotypes in Older Tuberculosis Patients: Associations with Anxiety, Depression, and Insomnia
Provisionally accepted
- Affiliated Hospital of Zunyi Medical University, Zunyi, China
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Introduction: Anxiety, depression, and insomnia are common among older patients with tuberculosis (TB), yet their associations with inflammatory responses and drug-induced liver injury (DILI) remain insufficiently explored. This study aimed to identify distinct inflammation-DILI phenotypes in older TB patients and examine differences in anxiety, depression, and insomnia across subgroups. Methods: In this cross-sectional study, 251 older TB patients were evaluated. Serum inflammatory markers and liver function indicators were collected, along with standardized assessments of anxiety, depression, and insomnia. Latent class analysis (LCA) was employed to classify inflammation-DILI phenotypes, and multinomial logistic regression was used to explore associations between subgroup characteristics and mental health outcomes. Results: Three latent subgroups were identified: (1) moderate inflammation with normal liver function (83.2%), (2) mild inflammation with abnormal liver function (5.3%), and (3) severe inflammation with normal liver function (11.5%). Compared with the moderate inflammation group, the severe inflammation group exhibited significantly higher rates of anxiety, depression, and insomnia. Alcohol consumption was a significant risk factor
Keywords: Anxiety, Depression, insomnia, Tuberculosis, Inflammation, Drug-Induced Liver Injury
Received: 08 Apr 2025; Accepted: 18 Aug 2025.
Copyright: © 2025 Lei, Liu, He and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhongmin Fu, Affiliated Hospital of Zunyi Medical University, Zunyi, China
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