ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Autism
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1610278
This article is part of the Research TopicInnovative and Cutting-edge Approaches to the Identification and Management of Autism Spectrum DisordersView all 9 articles
The value of intellectual structural imbalance in the differentiation of Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder
Provisionally accepted
Danyang Zhang1Qiuhong Wei1
Tingyu Li2*Binyue Hu1Dan Ai1Yu Zhang1
Yuan Ding1Ting Yang1
Jie Chen1Li Chen1Yuan Wu1Hongyu Chen1Xueli Xiang1Qiuhong Mou1- 1Children‘s Hospital of Chongqing Medical University, Chongqing, Chongqing Municipality, China
- 2Chongqing Medical University, Chongqing, China
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The study delves into the intricate task of differentiating intellectual structures among children diagnosed with the high-functioning Autism Spectrum Disorder (HF-ASD), Attention Deficit Hyperactivity Disorder (ADHD), or comorbidity (ASD+ADHD), aiming to assist in their clinical differentiation, with the goal of refining clinical diagnoses and developing targeted therapeutic interventions.The study included 200 outpatients aged 6.5-13.0 years (total Intelligence Quotient (IQ) 70-130) at the Children's Hospital of Chongqing Medical University, and categorized into HF-ASD (n=91), ADHD (n=47), and comorbidity ASD+ADHD (n=62) groups. We utilized the Chinese Wechsler Intelligence Scale for Children (C-WISC) as the primary assessment tool, supplemented by additional diagnostic measures. Besides, we used SPSS 25.0 to assess the subtest scores and differences.The comorbidity group had lower total IQ than the other two groups (p<0.001). The verbal IQ(VIQ) were lower than the performance IQ(PIQ) in HF-ASD (p=0.017) and comorbidity (p=0.007) groups. They also scored higher on perceptual organization subtests particularly in Block Design and Object Assembly than the ADHD group. The ADHD group showed higher VIQ than PIQ (p=0.020). The ADHD group's scores for working memory subtests were lower than in the HF-ASD group.The respective peak scores for the HF-ASD and comorbidity groups were in Block Design (45%,43%) and Object Assembly (30%,37%) and valleys in Picture Completion (52%,24%), Information (HF-ASD 24%), and Arithmetic (comorbidity 42%).The peak-valley difference in the ADHD group (~2 standard deviations) was smaller than in the HF-ASD and comorbidity groups (~3 standard deviations), and this characteristic could help differentiate between HF-ASD, ADHD, and both together.
Keywords: Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Wechsler Intelligence Scale of Children ( C-WISC), intellectual structures, Comorbidity
Received: 11 Apr 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 Zhang, Wei, Li, Hu, Ai, Zhang, Ding, Yang, Chen, Chen, Wu, Chen, Xiang and Mou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tingyu Li, Chongqing Medical University, Chongqing, China
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