ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Anxiety and Stress Disorders
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1611129
A Comparative Evaluation of EEG Power Spectrum Characteristics Between Two Methods for Alleviating Preoperative Anxiety in Breast Cancer Patients
Provisionally accepted
- 1Shanxi Provincial Cancer Hospital, Taiyuan, Shanxi Province, China
- 2Shanxi Medical University, Taiyuan, China
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Women with breast cancer are prone to moderate to severe preoperative anxiety. Effective measures for preventing and managing preoperative anxiety include drug therapy and nondrug intervention. The main evaluation method is scale assessment, which has certain limitations and may involve human concealment or evaluation errors. In this study, resting-state electroencephalography (EEG) was used to explore changes in power spectrum during the alleviation of preoperative anxiety in breast cancer patients, which is of great significance for objectively identifying and evaluating preoperative anxiety in patients.Methods: 40 breast cancer patients were randomly divided into two groups (20 patients per group), receiving either psychological intervention (PI) or intravenous midazolam (MID) before surgery. Visual Analog Scale for Anxiety (VAS-A) and Observer's assessment alert/Sedation (OAA/S) scores, clinical monitoring indexes and EEG data were measured before and after intervention.Results: VAS-A scores significantly decreased in both groups (p < 0.05), the power in the theta band of the frontal parietal regions decreased (p < 0.05) and was positively correlated with VAS-A scores (p < 0.001). Network analysis revealed that the three highest centrality measures in the PI group were located in the alpha band frontal parietal region, frontal central region, and gamma band parietal region, while the OAA/S scores showed the highest centrality for all three measures in the MID group.Both PI and intravenous MID can effectively alleviate preoperative anxiety in breast cancer patients, but their neuroelectrophysiological mechanisms were not entirely the same. Regarding the relationship between brain region power and monitoring indexes, the power of three specific regions in certain frequency bands was the primary factor in the PI group, while the level of sedation was the determining factor in the MID group.
Keywords: EEG power spectrum, preoperative anxiety, psychological intervention, Midazolam, Network analysis
Received: 13 Apr 2025; Accepted: 10 Jul 2025.
Copyright: © 2025 Jin, Wang, Jiang, Wu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ying Wu, Shanxi Medical University, Taiyuan, China
Yi Liu, Shanxi Provincial Cancer Hospital, Taiyuan, Shanxi Province, China
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