ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Public Mental Health
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1618041
Association of brain-derived neurotrophic factor levels at different trimesters and new-onset depressive symptom in the third trimester among pregnant women: a longitudinal study
Provisionally accepted
- 1Nanjing Jinling Hospital, Nanjing, China
- 2Affiliated Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China
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Accumulating evidence e suggests that brain-derived neurotrophic factor (BDNF) may play a role in the development of depression. However, changes in serum BDNF during distinct gestational periods and their association with prenatal depression remain unclear.: To investigate the change of serum BDNF in the first, second and third trimester and their longitudinal association with depressive symptoms in the third trimester. Methods: Depressive symptoms in the first and third trimester were assessed using the Patient Health Questionnaire-9 (PHQ-9). An automatic biochemical analyzer was used to detect serum BDNF levels based on enzyme-linked immunosorbent assay (ELISA) in the first, second and third trimester. Linear regression, binary and multivariable logistic regression model were used to analyze the association between BDNF levels during different pregnancy with PHQ-9 score and depressive symptoms in the third trimester.The mean age of 500 pregnant women included in this study was (26.8±2.3) years in the first trimester. At the third trimester, a total of 72 pregnant women (14.4%) developed depressive symptoms. The average serum BDNF level was highest in the first trimester and lowest in the second trimester. Each 1 pg/mL increase of first trimester BDNF was associated with a 43% decrease in the risk of prenatal depressive symptoms (95% confidence interval [95% CI]: 0.51, 0.65); each 1 pg/mL increase of second trimester BDNF was a 39% decrease in the risk of prenatal depressive symptoms (95% CI: 0.54, 0.68); each 1 pg/mL increase of third trimester BDNF was associated with a 36% decrease in the risk of prenatal depressive symptoms (95% CI: 0.58, 0.71).Overall, serum BDNF levels in the first, second, and third trimester were significantly associated with decreased PHQ-9 score and reduced risk of prenatal depressive symptoms. Serum BDNF shows promise as a predictive biomarker for antenatal depressive symptoms across all trimesters.
Keywords: Pregnancy, Pregnant Women, Depression, Depressive symptom, Brain-49
Received: 25 Apr 2025; Accepted: 10 Jul 2025.
Copyright: © 2025 Zhang, Liu, Wu, Yan, Lou and Ni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Juan Ni, Affiliated Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China
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