ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Neuroimaging
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1622726
Investigating Biomarkers for Personality Alterations in Temporal Lobe Epilepsy Patients: Based on Peripheral Inflammatory Indices, Electroencephalography, and Neuroimaging
Provisionally accepted
jia wang
Fuchi ZhangYunshan ZhouXiulin Zhang
Jianyang Xu
Shouyong Wang
Cheng-bing HuangTaipeng SunHugen Xu*
Xiangsong Shi*- Huai'an No.3 People's Hospital, Huian, China
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The investigation of personality alterations in temporal lobe epilepsy (TLE) constitutes a complex and demanding field of research. These alterations may be intricately linked to neuroinflammation, imaging changes, and electrophysiological irregularities.Objective: This study aims to explore the potential value of the peripheral inflammatory indices, video electroencephalogram (VEEG), hippocampal magnetic resonance imaging (MRI) as biomarkers for personality changes in patients with TLE.Methods: A total of 110 individuals with TLE were categorized into two groups: 55 patients exhibiting personality alterations and 55 patients without personality abnormalities. A supplementary cohort of 150 healthy individuals was enlisted as a control group. Demographic information, clinical attributes, inflammatory biomarkers, hippocampus MRI, and video EEG data were gathered and subjected to statistical analysis utilizing SPSS software.In comparison to the healthy control group, patients with TLE demonstrated markedly reduced counts of neutrophils, lymphocytes, and platelets, although the monocyte-to-lymphocyte ratio (MLR) was considerably elevated (all P<0.05). The cohort exhibiting personality alterations demonstrated an extended disease duration, an elevated incidence of hippocampal sclerosis or atrophy on MRI, and a reduced rate of monotherapy relative to the cohort without personality alterations (P<0.05). Binary logistic regression research indicated no significant correlation between personality alterations in patients with TLE and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), MLR, systemic immune-inflammation index (SII), or panimmune-inflammation value (PIV).Conclusions: MLR was markedly elevated in patients with TLE relative to healthy controls.Hippocampal sclerosis or atrophy constituted an independent risk factor for personality alterations in TLE, although monotherapy seemed to serve as a protective factor.
Keywords: Temporal Lobe Epilepsy, Personality alterations, Inflammatory biomarkers, Magnetic Resonance Imaging, Video electroencephalography
Received: 04 May 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 wang, Zhang, Zhou, Zhang, Xu, Wang, Huang, Sun, Xu and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hugen Xu, Huai'an No.3 People's Hospital, Huian, China
Xiangsong Shi, Huai'an No.3 People's Hospital, Huian, China
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