CASE REPORT article
Front. Psychiatry
Sec. Psychopharmacology
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1623256
This article is part of the Research TopicCase Reports in Psychopharmacology, volume IIIView all 9 articles
Successful Treatment of PGAD/GPD with Leuprolide: A Case Report
Provisionally accepted
- Department of Endocrinology, First Affiliated Hospital, Nanjing Medical University, Nanjing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Persistent genital arousal disorder/genitopelvic dysesthesia (PGAD/GPD) is a rare clinical condition of uncertain etiology. It is characterized by involuntary genital arousal occurring in the absence of sexual interest or desire, and may be accompanied by abnormal sensations in the pelvic and reproductive regions. PGAD/GPD exerts a profound negative impact on patients' physical and mental health, severely impairing daily functioning and, in some cases, leading to suicidal ideation. This case highlights the potential role of COVID-19 as a triggering factor in the development of PGAD/GPD. The marked improvement in symptoms following treatment with leuprolide suggests that dysregulation of gonadotropin/GnRH signaling may constitute a key pathogenic mechanism underlying this condition. We anticipate that this successful treatment case will provide valuable insights into the etiology and treatment strategies of PGAD/GPD.
Keywords: Leuprolide, case report, Treatment, PGAD, GPD (Generalised Pareto Distribution)
Received: 10 May 2025; Accepted: 10 Jul 2025.
Copyright: © 2025 Rong, Zhou and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hong-Qi Fan, Department of Endocrinology, First Affiliated Hospital, Nanjing Medical University, Nanjing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.