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ORIGINAL RESEARCH article

Front. Psychiatry

Sec. Schizophrenia

Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1627203

This article is part of the Research TopicInterplay of Inflammation and Schizophrenia: Pathophysiology and Therapeutic OpportunitiesView all articles

Childhood trauma and relationship with the parents: associations with lipids, glucose, and prolactin levels during antipsychotic treatment in patients with first-episode psychosis

Provisionally accepted
Marianne  LaffelyMarianne Laffely1*Claire  GrosuClaire Grosu1Nermine  LaaboubNermine Laaboub1Philippe  GolayPhilippe Golay2Luis  AlamedaLuis Alameda1Philippe  ConusPhilippe Conus1Chin  Bin EapChin Bin Eap1
  • 1Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
  • 2La Source, Lausanne, Switzerland

The final, formatted version of the article will be published soon.

Background: Besides antipsychotics and other clinical factors, childhood trauma (CT) may also alter metabolic and endocrine profiles. The aim was to determine whether CT influence metabolic profiles and prolactin levels in patients with first-episode psychosis treated with antipsychotics for up to one year. The quality of the relationship with the parents was also investigated. Methods: Two hundred twenty-six patients with low-density lipoprotein (LDL), high-density lipoprotein (HDL), non-HDL, total cholesterol, triglycerides, fasting plasma glucose, and prolactin levels monitored routinely before and during antipsychotic treatment were included. CT refers to physical, sexual, or emotional abuse occurring before the prodromal phase and up to 16 years old and was assessed during the patients' 3 years follow-up. The quality of the relationship with parents was assessed at the beginning of the follow-up. Results: After 12 months, CT was associated with an increase in total and non-HDL cholesterol levels (+17%, 95%CI:[0.4; 34]; +11%, 95%CI:[0.4; 21], respectively). Lack of a good relationship with the father was associated at 2 and 12 months with above-median levels of LDL (OR=5.

Keywords: 5, 95%CI:[1.3, 28], OR=3.7, 95%CI:[1.3, 12], respectively) and non-HDL (OR=4.7, 95%CI:[1.3, 19], OR=2.8, 95%CI:[1.0, 8.0], respectively Childhood trauma, First-episode psychosis, Lipids

Received: 12 May 2025; Accepted: 17 Jul 2025.

Copyright: © 2025 Laffely, Grosu, Laaboub, Golay, Alameda, Conus and Eap. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Marianne Laffely, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland

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