REVIEW article
Front. Psychiatry
Sec. Mood Disorders
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1629182
Gut Microbiota Dysbiosis Induces Neuroinflammation in Major Depressive Disorders: Mechanisms Targeting the Gut-Brain Axis
Provisionally accepted
- 1Jiangsu University, Zhenjiang, China
- 2Sichuan Normal University, Chengdu, China
- 3Texas A&M University, Temple, United States
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Keywords: neuroinflammation; MDD; gut-brain axis; microglia; astrocytes Conflict of Interest:The authors declare no potential conflict of interest. Author Contributions: SG, FW and JHH contributed to the conception and design of the study, and wrote the first draft of the manuscript. LZ, BW and XQ wrote sections of the manuscript, QX, XM, JHH and SG did a revision. All authors contributed to the manuscript revision, the read, and approved the submitted version. Acknowledgement: The work was partly supported by National Nature Science Foundation in China (82171392 FW), and also by a grant from Shanghai Zongchenghuihai medical technology company, grant name is the mechanism of anti-depressive effect of ICMF.
Keywords: Neuroinflammation, MDD, gut-brain axis, Microglia, Astrocytes
Received: 16 May 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 Li, Wan, Zhou, Qian, Wang, Gu and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fushun Wang, Sichuan Normal University, Chengdu, China
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