ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Mood Disorders
This article is part of the Research TopicInnovations in Psychological Care for Oncology and Palliative Settings: A Holistic ApproachView all 19 articles
Association of peripheral eosinophil levels with depressive disorder in endometrial cancer patients
Provisionally accepted
- 1Nankai University, Tianjin, China
- 2Tianjin Hospital, Tianjin, China
- 31st Medical Center of Chinese PLA General Hospital, Beijing, China
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Background Patients with endometrial cancer are prone to depressive disorder, yet the mechanisms underlying this comorbidity remain unclear. This study aimed to investigate the association between eosinophils and depressive disorder in these patients, providing a reference for unraveling the mechanisms of this psychiatric comorbidity. Methods A total of 421 newly diagnosed endometrial cancer patients were enrolled from communities, all receiving anti-tumor treatment at medical institutions based on their conditions. A single face-to-face interview was conducted at three months after diagnosis, during which: (1) eosinophil levels at diagnosis and other research data were collected from medical records; (2) current depressive disorder status was assessed using the Beck Depression Inventory-II; (3) blood samples were collected to measure current peripheral eosinophils, interleukin-5, and eotaxin levels at the time of interview. Multivariate logistic and linear regression were used for data analysis. Results Both elevated peripheral eosinophil levels at the time of diagnosis and at three months after diagnosis were significantly associated with an increased risk of depressive disorder or higher depressive disorder scores at three months after diagnosis. Additionally, elevated peripheral interleukin-5 and eotaxin levels at three months after diagnosis were also significantly associated with an increased risk of depressive disorder or higher depressive disorder scores at the same time point. 3 Conclusion Eosinophil levels in patients with endometrial cancer exhibit links to depressive comorbidities. The former may potentially be a contributing factor to or partially involved in the pathogenesis of the latter, though further validation is required.
Keywords: Depressive Disorder, endometrial cancer, eosinophil, Eotaxin, Interleukin-5
Received: 10 Jun 2025; Accepted: 07 Nov 2025.
Copyright: © 2025 Gao, Wang, Yan and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhifeng Yan, yangzhifeng202006@outlook.com
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