Editorial: Advances in Brain Functional Network Reconfiguration in Psychosis

Chenfei Ye^1*Andreia Vasconcellos Faria²Haoran Dou³

• ¹Harbin Institute of Technology, Shenzhen, Shenzhen, China
• ²The Johns Hopkins University School of Medicine, Baltimore, United States
• ³Sichuan Normal University, Chengdu, China

Psychotic disorders, including schizophrenia, bipolar disorder with psychotic features, and related conditions, are characterized by profound disruptions in brain functional connectivity. These disruptions often manifest as aberrant reconfiguration of neural networks, affecting cognition, emotion regulation, and perception. The Research Topic "Advances in Brain Functional Network Reconfiguration in Psychosis" seeks to elucidate the mechanisms underlying these dynamic network changes, with a focus on neuroimaging evidence, clinical implications, and innovative therapeutic interventions. By integrating image markers from functional magnetic resonance imaging (fMRI), this collection aims to advance our understanding of how brain networks adapt, or fail to adapt, in psychosis, ultimately informing novel diagnostic and treatment strategies. In a broader context, this work aligns with emerging paradigms in network neuroscience, where psychosis is viewed not as isolated regional deficits but as systemic imbalances in large-scale brain networks such as the default mode network (DMN), salience network, and central executive network [1]. Such frameworks hold promise for personalized medicine, bridging basic research with clinical applications to mitigate the global burden of psychotic disorders. This Research Topic brings together four original contributions that collectively highlight the multifaceted nature of brain network reconfiguration in psychosis and related conditions.Moving beyond a mere cataloging of findings, we emphasize how they interconnect to reveal patterns of neural plasticity, treatment-induced modulation, and methodological innovations. Together, these articles illuminate the potential of neuroimaging to map psychosis-related network dynamics, while advocating for integrative approaches like acupuncture and TMS to induce beneficial reconfigurations. They also identify critical gaps, particularly the need for longitudinal designs and larger cohorts to address biases inherent in non-randomized trials.Within the broader landscape of psychiatric research, this Research Topic contributes to a paradigm shift towards network-based models, fostering interdisciplinary collaboration to translate these insights into clinical practice. These contributions emphasize the centrality of adaptive brain network function in recovery and resilience. Looking ahead, future studies should explore multimodal neuromodulation strategies (e.g., combining acupuncture and TMS) to investigate common mechanisms of brain network regulation across psychiatric disorders [3].