CASE REPORT article
Front. Psychiatry
Sec. Perinatal Psychiatry
Volume 16 - 2025 | doi: 10.3389/fpsyt.2025.1695165
This article is part of the Research TopicPerinatal mental health: Depression, Anxiety, Stress, and FearView all 25 articles
Acute Hepatitis B Virus Infection in Pregnancy: A Case Report of Three Patients with Comorbid Anxiety and Their Clinical Outcomes
Provisionally accepted
- 1Zhejiang Chinese Medical University, Hangzhou, China
- 2Department of Gastroenterology, Third People's Hospital of Hangzhou, Hangzhou, China
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This case series reports three pregnant women with acute hepatitis B virus (AHB) infection, exploring their clinical outcomes and comorbid anxiety. All three patients presented with abnormal liver function and positive HBV markers. They received supportive therapy (liver-protective, enzyme-lowering agents, etc.), achieving HBsAg clearance and virological cure, with normal liver function during follow-up (one patient lost to follow-up). Despite favorable biomedical outcomes, all experienced significant anxiety over maternal-fetal health and disease progression. This study emphasizes that AHB in pregnancy, though usually self-limited, requires integrating psychosocial support into multidisciplinary management to address perinatal mental health, supporting WHO's 2030 viral hepatitis elimination goal.
Keywords: Acute hepatitis B, Perinatal mental health, Virological clearance, Early gestation, case report
Received: 29 Aug 2025; Accepted: 10 Oct 2025.
Copyright: © 2025 Wu, Hu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yufang Wang, wangyufang2007@126.com
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