Association between mild cognitive impairment and sleep quality in patients with chronic heart failure: a cross-sectional study

Objective: Mild cognitive impairment (MCI) has increasingly been recognized as a significant comorbidity in patients with chronic heart failure (CHF), adversely affecting prognosis and quality of life, despite limited research examining the role of sleep quality in this relationship. This study aimed to assess the prevalence of MCI and poor sleep quality in patients with CHF and to examine the association between them.

Methods: We conducted a cross-sectional study among 329 patients with CHF recruited from a hospital in Nanning, China, between September 2024 and June 2025. We collected the sociodemographic and clinical characteristics from all participants using a general information questionnaire. We assessed global cognitive function with the Beijing version of the Montreal Cognitive Assessment Scale (MoCA-BJ) and evaluated subjective sleep quality over the preceding one-month period using the Pittsburgh Sleep Scale Index (PSQI). We examined the association between MCI and sleep quality using point-biserial correlation coefficient analysis, and then further assessed it with hierarchical regression models, adjusting for potential confounders.

Results: The study revealed high prevalence rates of both MCI (58%) and poor sleep quality (70.52%) in the CHF population. A significant positive correlation was identified between MCI and poor sleep quality (r = 0.322, P < 0.01). Multivariable analysis demonstrated that sleep quality remained independently associated with MCI after adjusting for other risk factors, with the final model explaining over half of the variance in MCI risk.

Conclusion: Poor sleep quality shows a strong independent association with MCI in CHF patients. These findings highlight the importance of sleep assessment in CHF management and suggest that addressing poor sleep quality may represent a valuable approach in comprehensive care strategies aimed at preserving cognitive function in this CHF population.

Introduction

Chronic heart failure (CHF) is a complex syndrome of inadequate cardiac output due to cardiac dysfunction, typically presenting with symptoms such as shortness of breath and peripheral edema (1). The global burden of CHF is escalating, driven by an aging population and the growing prevalence of risk factors such as hypertension, obesity, and diabetes (2). The American Heart Association reported in its 2022 statistics that over 64.3 million individuals worldwide were living with CHF (3), representing approximately 1% to 2% of the global population (4). Furthermore, the prevalence of CHF is projected to increase by 46% by 2030 (5), highlighting a notable projected growth and its substantial expanding public health challenge. The clinical burden is accompanied by a substantial economic one, with CHF estimated to cost the global economy up to $108 billion annually in both direct medical expenses and indirect costs (6). Consequently, this trend continues to place sustained pressure on healthcare systems worldwide.

Given the significant clinical and economic burden of CHF, it is imperative to understand its associated comorbidities, particularly cognitive impairment. Cognition refers to the neuropsychological processes involved in constructing mental representations from the perception, processing, and synthesis of external information, which subsequently enables the acquisition of applicable knowledge (7). Cognitive impairment is an acquired and persistent clinical syndrome marked by deterioration in cognitive domains (8). This decline results in reduced capacity for daily activities and occupational functioning, and can also lead to behavioral alterations (9). Notably, mild cognitive impairment (MCI)represents a transitional state between normal cognitive aging and dementia, with a conversion rate to dementia of 10% to 15% per year (10).

Patients with CHF exhibit an elevated prevalence of MCI compared with the general population, with rates reported to be 1.5 to 2 times higher (11). A multicenter study in Italy showed that the prevalence of MCI among 1,511 hospitalized patients with CHF was 35% (12). Similarly, a Singaporean cohort study of 100 patients with chronic compensated CHF found a prevalence of 78% for MCI (13). Collectively, these findings demonstrate a high prevalence of MCI among individuals with CHF, which substantially affects their quality of life. Furthermore, established risk factors and clinical correlates for MCI in this patient population include age, lower educational level, BMI, nutritional status, and systemic inflammatory markers (14–16). Therefore, early detection of cognitive decline in CHF patients followed by timely intervention may help stabilize cognitive function slow its deterioration and improve overall quality of life.

Beyond cognitive impairment, another highly prevalent and interconnected comorbidity in patients with CHF is sleep disorders. Sleep disorders are defined as disruptions in the sleep-wake cycle, encompassing abnormalities in sleep quality, duration, or timing, along with undesirable behavioral or physiological events (17). Common manifestations include insomnia, circadian rhythm sleep-wake disorders, night terrors, and nightmares (18). It is estimated that approximately 75% of patients with CHF experience sleep disorders (19). By exacerbating autonomic dysfunction, accelerating disease progression, and impairing cardiac function, these disorders thereby significantly diminish patients’ quality of life (20). In addition, sleep disorders contribute to cognitive deficits through disruptions in neural plasticity synaptic communication and neurotransmitter balance (21). A quantitative meta-analysis further indicated that sleep initiation difficulties insufficient sleep duration and daytime sleepiness contribute to cerebral beta-amyloid deposition thereby elevating cognitive impairment risk (22, 23). While its cross-sectional design precludes causal inference, a large sample community-based study further supports the association between sleep disorders and MCI risk (24).

Although previous studies have linked poor sleep quality to MCI risk, limited research has directly investigated this relationship within the specific CHF population. Therefore, this study aims to clarify the correlation between MCI and sleep quality in patients with CHF to inform the development of targeted interventions for improving prognosis.

Materials and methods

Study participants and design

We conducted a cross-sectional study and recruited 329 patients with CHF from the Department of Cardiovascular Medicine of a tertiary hospital in Nanning, Guangxi, China, between September 2024 and June 2025. We identified potential participants by screening the hospital HIS for chronic heart failure diagnoses. Eligible patients who met all criteria were approached for participation.

The inclusion criteria were as follows: (1) Diagnosis of CHF according to the "Chinese Guidelines for the Diagnosis and Treatment of Heart Failure 2024"(25); (2) Age≥18 years; (3) Willingness to participate in the study.

The exclusion criteria were as follows: (1) Diagnosis of dementia or other major neurocognitive disorders; (2) Use of psychotropic or antiepileptic medications; (3) Presence of severe neurological conditions (such as Parkinson's disease, stroke with significant functional impairment, or other neurodegenerative disorders); (4) Any condition that would preclude cooperation with study protocols.

Sample size

The sample size was determined using G*Power 3.1 version (26). Based on a logistic regression model, the calculation assumed an α error probability of 0.05, a statistical power of 0.95, 24 predictor variables, and an expected effect size R² of 0.15. The minimum sample size required was calculated to be 277 cases. Considering the 10% data instability, it was finally determined to include 329 patients.

Measurement methods

General information questionnaire

It includes the following contents (1):General demographic information of the patient: age, sex, BMI, educational level, marital status (2);Disease-related data: smoking history, drinking history, NYHA class, hypertension, diabetes, stroke, atrial fibrillation (3);Examination report and laboratory indicators: Hemoglobin, high-sensitivity C-reactive protein(hs-CRP), total cholesterol, triglycerides (TG), serum creatinine (Scr), aspartate aminotransferase (AST), alanine aminotransferase (ALT), NT-ProBNP, left ventricular ejection fraction (LVEF).

The Beijing version of the Montreal cognitive assessment scale

The MoCA-BJ was originally developed by Nasreddine et al. (27) and subsequently translated and culturally adapted into Chinese by Yang et al. (28). It has been widely used in China for assessing cognitive impairment. The scale has 12 items with a total score of 30. The assessment covers eight cognitive domains, including memory, delayed recall, visuospatial/executive functions, naming, attention, language, abstraction, and orientation. Higher scores indicate better cognitive function. A score of ≥26 suggests normal cognition, 16–25 suggests MCI, and a score below 16 indicates severe cognitive impairment. For participants with ≤12 years of education, one point was added to the total score, with a maximum score of 30. The Cronbach’sα coefficient of this scale is 0.82.

Pittsburgh sleep quality index

The PSQI was developed by Buysse et al. (29) and translated by Chinese scholars Liu Xianchen et al. (30). It is used to assess the subjective sleep quality over the past month. The PSQI comprises 19 items categorized into seven subdomains: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleep medication, and daytime dysfunction. Each component is scored from 0 to 3, resulting in a global score that ranges from 0 to 21. A total score >7 is indicative of poor sleep quality. The scale has demonstrated good test-retest reliability and validity. The Cronbach’sα coefficient of this scale is 0.84.

Patient health questionnaire-9 depression scale

The scale was developed by American scholars Spitzer et al. (31) and translated into Chinese by Bian Cuidong et al. (32). It is an important tool for screening and assessing depressive symptoms, consisting of 9 items to evaluate the feelings of the subjects in the past two weeks. The total score ranges from 0 to 27 points. The degree of depressive symptoms is classified based on the total score into none (0–4 points), mild depressive symptoms(5–9 points), moderate depressive symptoms(10–14 points), moderate-to-severe depressive symptoms(15–19 points), and severe depressive symptoms(20–27 points). The Cronbach’sα coefficient of this scale is 0.771.

Generalized anxiety disorder scale

The GAD-7 scale was developed by Spitzer et al. (33). This scale has 7 items with a total score of 21. Anxiety symptoms is classified based on the total score as none (0–4 points), mild anxiety symptoms(5–9 points), moderate anxiety symptoms(10–14 points), and severe anxiety symptoms(15–21 points). The Cronbach’sα coefficient of this scale is 0.92 (34).

Controlling nutritional status score

The CONUT score was developed by de Ulibarri et al. (35) in 2005 as a tool for nutritional screening and monitoring. In recent years, it has been widely used among hospitalized patients with various chronic diseases such as cancer and cardiovascular diseases. This tool consists of three parameters: The total score is obtained by adding up the scores of serum Albumin concentration (ALB), peripheral lymphocyte count (LYM), and total cholesterol concentration (TC). The total score ranges from 0 to 12 points. The higher total score indicates a greater risk of malnutrition (36).

Data collection

The researcher explained the purpose, significance, methods, and principles of confidentiality and anonymity pertaining to the study to each patient. Additionally, any questions raised by patients were addressed patiently by the researcher. Upon agreement from the patient, they scanned a QR code linked to a questionnaire for completion while receiving assistance from the researcher based on standardized instructions. The estimated time for filling out the questionnaire was approximately 15 to 20 minutes. After completion, researchers reviewed each questionnaire for errors or omissions and promptly clarified any uncertain responses with patients before submitting electronic forms to ensure accuracy. Furthermore, disease-related information along with biochemical test reports were collected from patients’ electronic medical records and cross-verified by two researchers to guarantee data reliability.

Statistical analysis

The data were analyzed and organized using SPSS version 27.0 software. Continuous data are presented as mean ± standard deviation or median with interquartile range (M (P25, P75)), while categorical data are described in terms of frequency and percentage. The normality of all continuous variables was assessed using the Shapiro-Wilk test. As none of the variables followed a normal distribution (all P < 0.05), non-parametric tests were used throughout the analysis. Group comparisons were performed using the Mann-Whitney U test for continuous variables and the chi-square test for categorical variables. Variables with significant associations with MCI (P < 0.05) in univariate analyses were eligible for inclusion in the binary logistic regression. Only those that retained statistical significance in the multivariate model were retained in the final analysis.

To assess the independent role of sleep quality, two models were constructed utilizing hierarchical regression (block input method): Model 1 (the benchmark model) incorporated only covariates such as demographic characteristics and medical history; Model 2 built upon Model 1 by additionally including total sleep quality scores as the primary independent variable. The model fit for each hierarchical block was assessed and compared. The improvement in model fit from Model 1 to Model 2 was formally tested using the Likelihood Ratio Test (LRT). This test is based on the difference in the -2 Log-Likelihood (-2LL) values between the nested models, which follows a chi-square distribution with degrees of freedom equal to the number of new parameters added. A significant P-value for the LRT indicates that the new block of variables significantly improves the model’s fit to the data. By comparing changes in -2LL across both models and conducting likelihood ratio tests, we evaluated the independent contribution of sleep quality to predictive capabilities within these models. Regression results are reported as odds ratios (OR) along with their corresponding 95% confidence intervals (CI). P value < 0.05 was deemed statistically significant.

Results

Baseline characteristics

A total of 334 patients with CHF were investigated in this study, of whom 5 patients were invalid. Therefore, 329 valid data were ultimately collected for analysis. A total of 191 patients of CHF patients with MCI, a rate of 58%. Among the 329 patients, the majority were male (233, 70.8%), while the remainder were female (96, 29.2%). The mean age of the patients was 63.0 years (IQR: 54.0-71.0), with the majority (67.5%) educated to a junior high school level or below. Compared to those without poor sleep quality, CHF patients with comorbid poor sleep quality showed statistically significant differences in age (Z = -8.059, P < 0.001), smoking history (Z = 8.073, P = 0.004), atrial fibrillation (χ² = 16.821, P < 0.001) and anxiety symptoms (χ² = 9.274, P = 0.01) (Table 1).

Table 1

Table 1. Baseline characteristics and differences in MCI(n=329).

Current status of sleep quality in patients with CHF

In this study, PSQI scores ranged from 2 to 19, with a median total score of 9.00 (IQR: 7.00–12.00). A total of 70.52% of the patients were classified as having poor sleep quality (PSQI > 7), among whom the median score was 10.00 (IQR: 9.00–12.00). Detailed scores for all PSQI components are presented in Table 2. The most severely impaired component was daytime dysfunction, followed by sleep duration.

Table 2

Table 2. Current status of sleep quality in patients with CHF(n=329).

Correlation between MCI and sleep quality in patients with CHF

The results indicated a positive correlation between MCI and overall sleep quality (r = 0.322, P < 0.01). Furthermore, MCI was significantly associated with subjective sleep quality, sleep latency, sleep duration, and habitual sleep efficiency. The corresponding correlation coefficients for each dimension are presented in Table 3. In contrast, no significant correlations were observed between MCI and sleep disturbance, the use of sleep medications, and daytime dysfunction (all P > 0.05).

Table 3

Table 3. Correlation between MCI and sleep quality in patients with CHF(n=329).

Risk factors for MCI in patients with CHF

Stratified binary logistic regression analysis was conducted with the occurrence of MCI as the dependent variable to identify independent risk factors. Model 1 included covariates such as demographic characteristics and medical history, while Model 2 added the total PSQI score to evaluate the independent role of sleep quality. The model fit indices demonstrated a good and improving fit across models. The -2LL decreased from 287.48 in Model 1 to 273.95 in Model 2, indicating a better fit with the addition of the sleep quality variable. The LRT confirmed that this improvement was statistically significant (Δχ² (1) = 13.53, P < 0.001). Furthermore, the explanatory power of the model increased substantially, with the Nagelkerke R² rising from 0.518 in Model 1 to 0.551 in Model 2, meaning that the full model (Model 2) explained 55.1% of the variance in MCI status. In the final adjusted model (Model 2), several factors were identified as statistically significant independent predictors of MCI: older age (OR = 1.066, 95% CI: 1.036-1.097, P < 0.001), lower educational attainment (all categories vs. reference, P < 0.05), higher nutritional risk (OR = 1.798, 95% CI: 1.464-2.208, P < 0.001), and poorer sleep quality (OR = 1.257, 95% CI: 1.107-1.428, P < 0.001). Specifically, for each one-point increase in the PSQI total score (indicating worse sleep quality), the odds of having MCI increased by 25.7% (Table 4).

Table 4

Table 4. Hierarchical regression analysis regarding predictors of MCI in patients with CHF(n=329).

Discussion

This study revealed a 58% prevalence of MCI in patients with CHF, a result consistent with the report by Xu Chengyang et al. (37) but lower than that reported by Karen K et al. (38). This high incidence rate may be attributed to differences such as the characteristics of the study population and the clinical environment. The patients with CHF included in this study were mainly aged and with low education level. Both advanced age and low educational level are well-established, non-modifiable risk factors for cognitive impairment. In the present study, a considerable burden of depressive and anxiety symptoms, alongside poor sleep quality, constituted prominent clinical features among the patients. Existing evidence (39) suggests that these factors may exacerbate cognitive decline through multiple pathways, including dysfunction of the hypothalamic-pituitary-adrenal axis, disruption of sleep architecture, and activation of chronic inflammatory processes. Although their association with cognitive impairment did not reach statistical significance in our dataset, these mechanisms have been well-documented in the literature, and their potential clinical relevance warrants attention. In addition, CHF often triggers a series of pathological alterations, such as cerebral hypoperfusion, thrombogenesis, systemic inflammatory responses, and protein toxicity, which collectively contribute to the development of MCI (40, 41).

MCI is recognized not only for its detrimental effects on quality of life and medication adherence but also as an independent risk factor for mortality among patients with CHF (42). Although cognitive training was shown by Davis et al. to improve knowledge levels in CHF patients with MCI, it did not significantly enhance self-care behaviors or reduce rehospitalization risk (43). A randomized clinical trial in Canada (44) indicated that combined aerobic-resistance exercise and computerized cognitive training can significantly improve overall cognitive function. Greater cognitive impairment is associated with poorer self-care, higher rehospitalization and mortality rates, and worse prognoses (45). In clinical practice, it is recommended to conduct MCI screening for patients with CHF as early as possible to identify cognitive decline at an early stage and take targeted intervention measures to effectively delay cognitive decline, improve cognitive status and enhance the quality of life.

Moreover, this study further confirmed a significant positive correlation between MCI and poor sleep quality in patients with CHF. The cross-sectional nature of our study precludes any causal inference regarding the relationship between sleep quality and MCI. While our hierarchical regression models identified poor sleep quality as a significant independent risk factor, the temporal sequence of this association remains unclear. It is biologically plausible that the relationship is bidirectional: chronic poor sleep quality may contribute to cognitive impairment through mechanisms such as impaired memory consolidation and increased neuroinflammation (46). Conversely, MCI itself could lead to poor sleep quality through dysregulation of the sleep-wake cycle, anxiety related to cognitive symptoms, or other neuropathological changes (47). Poor sleep quality may act as a predisposing factor for anxiety and depressive symptoms, which could subsequently play a mediating role in the development or progression of MCI, with underlying neurophysiological alterations potentially reinforcing these interrelationships (48). Therefore, we recommend incorporating the PSQI as part of standard admission assessments for patients with CHF, with special consideration for identified high-risk subgroups such as older adults, individuals with lower educational attainment, and those at nutritional risk. Furthermore, systematic referral mechanisms should be implemented to facilitate access to dedicated sleep specialists for patients identified with clinically sleep disorders. Moreover, clinicians should prioritize evidence-based non-pharmacological strategies such as sleep hygiene education, stimulus control therapy, and cognitive behavioral therapy for insomnia as first-line treatments (49). Future randomized controlled trials are necessary to establish the benefits of these integrated care approaches on sleep parameters and cognitive function in patients with CHF.

Similar to previous research results, our research findings indicated that MCI is closely related to age, with risk progressively increasing among older individuals (50). The progression of age-related cognitive decline is significantly accelerated in patients with CHF (51). Age-related cognitive decline emerges through multiple interconnected degenerative processes, including compromised cerebrovascular autoregulation, neuronal loss, white matter lesions, and sustained neuroinflammation, which together undermine cerebral integrity (52). The persistent cerebral hypoperfusion resulting from reduced cardiac output interacts synergistically with the inherent vascular regulatory deficiencies of the aging brain, collectively compromising the structural and functional integrity of brain regions critical for cognition (40). This mechanism of heart-brain interaction makes elderly patients with heart failure an extremely high-risk group for MCI. Therefore, it is recommended to implement enhanced cognitive screening and multidisciplinary management for elderly patients with CHF, integrating HF treatment with cognitive protection strategies. This includes adapting CHF therapy to incorporate cerebroprotective objectives, optimizing blood pressure control to maintain cerebral perfusion pressure, and prioritizing medications with demonstrated neuroprotective properties.

Furthermore, this study confirmed that low educational level is significantly associated with an increased risk of MCI. Education serves as a form of cognitive reserve and is a recognized protective factor for cognitive function (53). Meta-analyses have consistently shown that higher educational levels correlate with better cognitive outcomes and reduced prevalence of MCI (54). Individuals with lower educational levels often exhibit diminished cognitive reserve, which can constrain their ability to compensate for neurodegenerative changes associated with aging or disease (55). Education fosters neuroplasticity and enhances neural efficiency, promoting the development of adaptive cognitive strategies that enable functional compensation for underlying brain pathology (56). Additionally, lower educational level is often linked to limited health literacy, which can impede effective disease self-management and increase cognitive load in patients already coping with CHF (57). In clinical practice, these findings underscore the value of identifying patients with low educational level as a high-risk subgroup for whom cognitive screening may be particularly beneficial. Providing health information in visually supported, plain-language formats may also help mitigate literacy-related barriers and support cognitive health in this population.

Nutritional risk was identified as a significant predictor of MCI, with underlying mechanisms involving multiple interrelated pathophysiological pathways. Key nutrients such as proteins, vitamin B12, vitamin D, and omega-3 fatty acids play critical roles in neurotransmitter synthesis, neuronal energy metabolism, and myelin integrity (58). In CHF patients, anorexia, malabsorption, and metabolic disturbances often lead to cardiac cachexia, which is closely linked to systemic inflammation (59). Subsequently, pro-inflammatory cytokines, notably TNF-α and IL-6, can traverse the blood-brain barrier, initiate neuroinflammatory processes, and ultimately damage memory-related regions (60). Inadequate levels of folate, vitamin B12, and antioxidants further impair brain maintenance and repair (61). Therefore, routine nutritional screening and early intervention are essential in CHF patients. Maintaining balanced nutrition supports both cardiac and cognitive health, highlighting diet as a key modifiable factor in multidisciplinary management strategies.

Although the associations between anxiety and depression symptoms with MCI did not reach statistical significance in our multivariate regression model, this result diverges from the established role of psychological factors reported by Najdaghi et al. (62). This lack of significance may be attributed to the demographic characteristics of our study population. Cognitive function appears to be more directly influenced by robust physiological factors such as cerebral hypoperfusion and nutritional risk, potentially masking the independent effects of psychological variables. Nevertheless, the clinical relevance of these psychological factors in patients with CHF warrants continued attention in both research and clinical practice. Persistent psychological stress can lead to hypothalamic-pituitary-adrenal (HPA) axis dysfunction, resulting in abnormal glucocorticoid levels that subsequently impair hippocampal neurogenesis and synaptic plasticity (63). Furthermore, patients with anxiety and depressive symptoms often experience poor sleep quality, social withdrawal, and reduced treatment adherence, all of which may indirectly accelerate cognitive decline (64). Therefore, integrating psychological symptom assessment into routine follow-up care for CHF patients using standardized instruments is recommended. For patients presenting with significant anxiety or depressive symptoms, appropriate psychological interventions should be considered. Maintaining awareness of patients’ psychological well-being may contribute to improved overall prognosis, consistent with comprehensive chronic disease management principles.

Limitations

This study had several limitations: First, The cross-sectional design cannot determine the direction of causality between sleep quality and MCI. It remains unclear whether poor sleep contributes to cognitive decline, or if early neurodegenerative changes of MCI disrupt sleep patterns. Second, sleep assessment relied on the PSQI, a subjective measure that may be susceptible to recall and self-reporting biases. The absence of complementary objective sleep measurements, such as actigraphy or polysomnography. Additionally, as the study was conducted at a single-center in China, the generalizability of the findings was limited. We recommend that future research employs longitudinal cohort studies to track the influence of sleep quality on MCI incidence over time and conducts interventional studies to test causal relationships. Furthermore, such studies should expand the sampling scope and incorporate objective sleep measurements to enhance the representativeness and robustness of the findings.

Conclusion

Poor sleep quality is an independent risk factor for MCI in patients with CHF, requiring increased clinical attention. Healthcare providers should routinely assess sleep quality and cognitive function in these patients. Individuals with poor sleep or additional risk factors receive early intervention and undergo long-term cognitive monitoring to track changes, with the aim of delaying cognitive decline and improving quality of life. Further research is recommended to examine the longitudinal trajectories of MCI and sleep quality in this population, which may help develop targeted intervention strategies.

Data availability statement

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

Ethics statement

The studies involving humans were approved by Full name: The Medical Ethics Committee of First Affiliated Hospital of Guangxi Medical University Affiliation:The First Affiliated Hospital of Guangxi Medical University. The studies were conducted in accordance with the local legislation and institutional requirements. The ethics committee/institutional review board waived the requirement of written informed consent for participation from the participants or the participants’ legal guardians/next of kin because as it utilized data obtained from previous clinical care and studies for which participants had provided broad consent for future research use. The collected data and information were encoded and treated confidentially.

Author contributions

YG: Conceptualization, Formal Analysis, Methodology, Validation, Writing – original draft, Writing – review & editing. TL: Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing. YD: Writing – original draft, Writing – review & editing. LFL: Conceptualization, Methodology, Writing – review & editing. LL: Conceptualization, Methodology, Writing – review & editing. WH: Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing. GL: Conceptualization, Data curation, Formal Analysis, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing.

Funding

The author(s) declare financial support was received for the research and/or publication of this article. This study was supported by the Nursing Clinical Research “Climbing” Program of the First Affiliated Hospital of Guangxi Medical University (YYZS2022017) and the self-funded Scientific Research Project of the Health Commission of Guangxi Zhuang Autonomous Region (Z20210671).

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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