ORIGINAL RESEARCH article
Front. Psychiatry
Sec. Sleep Disorders
This article is part of the Research TopicMild cognitive impairment and cognitive agingView all 10 articles
Association between mild cognitive impairment and sleep quality in patients with chronic heart failure: A cross-sectional study
Provisionally accepted
- The First Affiliated Hospital of Guangxi Meidical University, Nanning, China
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Objective: Mild cognitive impairment (MCI) has increasingly been recognized as a significant comorbidity in patients with chronic heart failure (CHF), adversely affecting prognosis and quality of life, despite limited research examining the role of sleep quality in this relationship. This study aimed to assess the prevalence of MCI and poor sleep quality in patients with CHF and to examine the association between them. Methods: We conducted a cross-sectional study among 329 patients with CHF recruited from a hospital in Nanning, China, between September 2024 and June 2025. We collected the sociodemographic and clinical characteristics from all participants using a general information questionnaire. We assessed global cognitive function with the Beijing version of the Montreal Cognitive Assessment Scale (MoCA-BJ) and evaluated subjective sleep quality over the preceding one-month period using the Pittsburgh Sleep Scale Index (PSQI). We examined the association between MCI and sleep quality using point-biserial correlation coefficient analysis, and then further assessed it with hierarchical regression models, adjusting for potential confounders. Results: The study revealed high prevalence rates of both MCI (58%) and poor sleep quality (70.52%) in the CHF population. A significant positive correlation was identified between MCI and poor sleep quality (r = 0.322, P < 0.01). Multivariable analysis demonstrated that sleep quality remained independently associated with MCI after adjusting for other risk factors, with the final model explaining over half of the variance in MCI risk. Conclusion: Poor sleep quality shows a strong independent association with MCI in CHF patients. These findings highlight the importance of sleep assessment in CHF management and suggest that addressing poor sleep quality may represent a valuable approach in comprehensive care strategies aimed at preserving cognitive function in this CHF population.
Keywords: chronic heart failure, Mild Cognitive Impairment, sleep quality, Sleep Disorders, Risk factors
Received: 19 Sep 2025; Accepted: 27 Oct 2025.
Copyright: © 2025 Gan, Liao, Du, Liu, Luo, Huang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wenghua Huang, huangwenhua@sr.gxmu.edu.cn
Gaoye Li, gxnnlgy@126.com
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