SYSTEMATIC REVIEW article
Front. Psychiatry
Sec. Aging Psychiatry
A Systematic Review and Meta-Analysis of the Effects of Resistance Exercise on Cognitive Function in Older Adults
Provisionally accepted
Jun Wu1
Chuanfu Huang2*- 1Shanghai University of Engineering Science, Shanghai, China
- 2University of Suwon, Hwaseong, Republic of Korea
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Objective:Cognitive decline has become a major concern with global population ageing, profoundly affecting quality of life and social participation in older adults. Resistance exercise has recently gained attention as a promising strategy to promote neuroplasticity and mitigate cognitive deterioration; however, evidence from randomized controlled trials (RCTs) remains inconsistent. This systematic review and meta-analysis aimed to evaluate the effects of resistance exercise on cognitive function in older adults and to examine whether improvements vary by age and whether exercise parameters—such as type, duration, session length, and weekly frequency—show dose–response relationships. Methods:PubMed, Web of Science, Cochrane Library, Embase, and Science Direct were systematically searched from database inception to September 2024 for RCTs investigating the effects of resistance training on cognitive function in older adults (≥60 years). Study quality was assessed using the Cochrane Risk of Bias 2 (ROB2) tool, and meta-analyses were conducted using RevMan 5.4 and Stata 17. Results: 17 RCTs (n =739) met the inclusion criteria. Pooled analyses showed that resistance training significantly improved overall cognitive function (SMD = 0.40, P < 0.05), working memory (SMD = 0.44, P < 0.001), verbal learning and memory (MD = 3.01, P < 0.001), and spatial memory span (SMD = 0.63, P < 0.001), whereas effects on processing speed, executive function, and attention were not significant (P > 0.05). Heterogeneity and publication bias analyses indicated stable and unbiased results. Conclusion:Resistance exercise exerts selective benefits on cognitive domains in older adults, particularly enhancing overall cognition, working memory, verbal learning, and spatial memory. The magnitude of improvement appears to depend on age and exercise parameters, suggesting a potential dose–response relationship. These findings provide evidence-based guidance for resistance training into cognitive health promotion and rehabilitation programs for ageing populations. Additional Information:This study is registered on PROSPERO (No. CRD42023407397), accessible at www.crd.york.ac.uk.
Keywords: Resistance Training, Cognitive Function, older adults, Meta-analysis, Systematic review
Received: 18 Sep 2025; Accepted: 25 Nov 2025.
Copyright: © 2025 Wu and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chuanfu Huang
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