MINI REVIEW article
Front. Rehabil. Sci.
Sec. Interventions for Rehabilitation
Volume 6 - 2025 | doi: 10.3389/fresc.2025.1593487
This article is part of the Research TopicNovel Rehabilitation Approaches for Non-Communicable Diseases in the Era of Precision MedicineView all 4 articles
A Brief Discussion on the Role of Calcitonin Gene-Related Peptide in the Efficacy of Rehabilitation Medicine
Provisionally accepted
- DongGuan Hospital of Traditional Chinese Medicine, Dongguan, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Calcitonin gene-related peptide (CGRP) is an active peptide composed of 37 amino acids that functions through specific receptors. It is widely distributed in small-diameter dorsal root ganglion neurons, trigeminal ganglion neurons, and nerve fibers innervating the spinal cord and brainstem dorsal horn. CGRP regulates various physiological functions, including vasodilation, inflammation modulation, and cardiac protection, and plays a key role in pain transmission. Pain is a global health challenge closely associated with the activity of neuropeptides such as CGRP. Although progress has been made in the application of CGRP in treating various diseases, research in the field of rehabilitation remains in its early stages. This article summarizes the roles of CGRP in peripheral nerve injury, central injury, cardiovascular rehabilitation, and pain rehabilitation. In terms of treatment, common physical therapies such as laser therapy and shock wave therapy have been shown to influence CGRP expression levels. However, the specific effects of these physical interventions on CGRP require more systematic future research and analysis to achieve more efficient and personalized rehabilitation strategies.
Keywords: GUAN Zhencheng (1996-), male, Certified Rehabilitation Therapist Calcitonin Gene-Related Peptide (CGRP), Physical and Rehabilitation Medicine, Pain Management, Neuroprotection, Vasodilation
Received: 20 Mar 2025; Accepted: 26 May 2025.
Copyright: © 2025 Guan and Xue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhencheng Guan, DongGuan Hospital of Traditional Chinese Medicine, Dongguan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.